Reposted by Ole Christian SylteMasahiro Nakano @masahironakano.bsky.social · 19/09/2026My first paper has been published in Hippocampus! bsky.app/profile/masa... Thank you Caswell and Claudia for your support!bsky.app 25010
Reposted by Ole Christian SylteAdrian Roggenbach @a-roggenbach.bsky.social · 24/08/2026⚠️PREPRINT ALERT⚠️ How can we better understand distributed brain activity across temporal and spatial scales? In this collaborative project, we combined ultra-flexible electrodes with two-photon imaging to illuminate brain-wide neural dynamics. Link: doi.org/10.21203/rs.... 1/8 13211
Reposted by Ole Christian SylteSainsbury Wellcome Centre @sainsburywellcome.bsky.social · 07/07/2026@neuroweiler.bsky.social, @olechsylte.bsky.social and Matilda Cloves are presenting posters tomorrow (8 July) 🙌 111
Reposted by Ole Christian SylteNora Roüast @norarouast.bsky.social · 26/06/2026Ever wondered what having auditory stimulation does to the sleep itself? Random stimulation disturbs SWS, memory, and travelling dynamics of slow waves. New paper in iScience with @mschoenauer.bsky.social, @denizkumral.bsky.social, and Steffen Gais! doi.org/10.1016/j.is... #sleep #neuroskyencedoi.orgRedirecting 1177
Reposted by Ole Christian Syltein-code.bsky.social @in-code.bsky.social · 24/06/2026Fantastic news for IN-CODE! Prof. Marlene Bartos (Uni Freiburg) secured a €2.5M ERC Advanced Grant for "ReMember-CA3". Her team will investigate how the hippocampal CA3 circuit encodes memories without overwriting old ones, and how it retrieves them over extended periods of time. #ERC #Neuroscience 0155
Reposted by Ole Christian SylteSainsbury Wellcome Centre @sainsburywellcome.bsky.social · 11/05/2026Calling all neuroscience postdocs! Come and share your work with the London neuroscience community. No CVs, publication records or recommendation letters needed. Learn more about SWC’s Emerging Neuroscientists Seminar Series and apply by 30 June: www.sainsburywellcome.org/web/content/... 01813
Reposted by Ole Christian SylteEelke Snoeren @eelkesnoeren.bsky.social · 21/04/2026Latest article from the lab is out: "Behavioral dynamics of different stages of sexual motivation in male and female rats".sciencedirect.comBehavioral dynamics of different stages of sexual motivation in male and female ratsSexual motivation is a complex concept involving both the initial drive to begin mating and the motivation to sustain copulation. Disruptions in sexua… 052
Reposted by Ole Christian SylteThibault Cholvin @thibaultcholvin.bsky.social · 30/03/2026I’m happy to share our new paper (with @mbartos.bsky.social) now out in Nature Neuroscience: "The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations" Download it @ rdcu.be/famDE More below 🧵 12510
Reposted by Ole Christian SylteKristine Heiney, PhD @krisheiney.bsky.social · 05/03/2026Out now in @plos.org CB: doi.org/10.1371/jour... Neural representations of tasks change over time, even in the absence of changes in task performance. But neurons change tuning at different rates. How does a neuron's stability relate to its interactions with the population? #compneuro #neuroskyencedoi.orgInformation theoretic measures of neural and behavioural coupling predict representational driftAuthor summary Activity in the brain represents information about the outside world and how we interact with it. Recent evidence shows that these representations slowly change day to day, while memori... 15418
Reposted by Ole Christian SylteAthena Akrami @athenaakrami.bsky.social · 16/02/2026Thrilled to finally share this work! 🧠🔊 Using a new reinforcement-free task we show mice (like humans) extract abstract structure from sound (unsupervised) & dCA1 is causally required by building factorised, orthogonal subspaces of abstract rules. Led by Dammy Onih! www.biorxiv.org/content/10.6...biorxiv.org 315752
Reposted by Ole Christian SylteSainsbury Wellcome Centre @sainsburywellcome.bsky.social · 12/02/2026Congratulations to @olechsylte.bsky.social on receiving a Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship! 🎉 Ole will investigate how the brain transforms spatial knowledge into goal-directed actions. 1102
Reposted by Ole Christian SylteChunyu Ann Duan @annduan.bsky.social · 14/12/2025New preprint from the lab! A frontal motor circuit for economic decisions and actions: www.biorxiv.org/content/10.6... We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.biorxiv.orgA frontal motor circuit for economic decisions and actionsFlexible behaviour requires transforming abstract cognitive representations, such as value preferences, into concrete motor actions. During economic decision-making, individuals evaluate options to gu... 57724
Reposted by Ole Christian SylteNora Jamann @norajamann.bsky.social · 04/12/2025Please share! 🧠 Opportunity for a PhD position: Studying interneurons and memory, using cutting-edge techniques, such as patch-clamp electrophysiology, in vivo calcium imaging, optogenetics and behavioral experiments. Interested? Have a look here for more information: www.fens.org/careers/job-...fens.orgPhD student (f/m/d) - Interneurons and memory - Federation of European Neuroscience Societies 065
Reposted by Ole Christian SylteAurore Cazala @acazala.bsky.social · 27/10/2025Now that the science days are over, I can happily share some of my designs :) Thanks to all the @in-code.bsky.social members who made these days a success! It was intense but worth it! And huge thanks to @sophiekb.bsky.social that was in charge of making this happen 053
Reposted by Ole Christian SylteGatsby Computational Neuroscience Unit @gatsbyucl.bsky.social · 25/09/2025🙋Are you interested in bridging theory & experiments? Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme. Join us and be part of a vibrant research community! 💰 Fully-funded 4-year programme ℹ️ www.ucl.ac.uk/life-science... @sainsburywellcome.bsky.social 01610
Reposted by Ole Christian SylteSainsbury Wellcome Centre @sainsburywellcome.bsky.social · 23/09/2025Applications are now open for the SWC Systems Neuroscience PhD Programme. Join us in London! 🧠 World-class neuroscience training 💰 Fully-funded 4-year programme 🖥️ Close links to @gatsbyucl.bsky.social Apply by 3 Nov: www.sainsburywellcome.org/web/content/... 23223
Reposted by Ole Christian SylteEelke Snoeren @eelkesnoeren.bsky.social · 14/08/2025🚨New paper alert! We studied the long-term consequences of SSRI use during pregnancy on the offspring in rats in a seminatural environment. We found that perinatal FLX exposure significantly increases sexual behavior in adult male rats. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyencesciencedirect.comPerinatal fluoxetine exposure increases male rat sexual behaviorSelective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to pregnant women due to their efficacy and safety profile, leading to potenti… 062
Reposted by Ole Christian SylteJens-Bastian Eppler @j-b-eppler.bsky.social · 04/08/2025And for me the big question is: What about representational drift? 😄 Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense? How can perception stay stable if the neurons keep changing? I’m sure manifolds will help us understand that too… 🧠🧪 3/3 251
Reposted by Ole Christian SylteEelke Snoeren @eelkesnoeren.bsky.social · 07/07/2025🚨 New Article Alert! 🚨 Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence @uitnorgesarktiske.bsky.social www.sciencedirect.com/science/arti...sciencedirect.comBehavioral and neural alterations of the ventral tegmental area by exposure to junk food in ratsThe brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, charact… 164
Reposted by Ole Christian SylteEelke Snoeren @eelkesnoeren.bsky.social · 31/05/2025New preprint alert! Perinatal fluoxetine exposure increases male rat sexual behavior. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyence 131
Reposted by Ole Christian SylteThe Transmitter @thetransmitter.bsky.social · 11/06/2025A non-value-based system in the brain automates decision-making and frees up cognitive resources for other tasks, a new study in mice suggests. By Holly Barker #neuroskyence www.thetransmitter.org/neurobiology...thetransmitter.orgDopamine neurons signal default behavior to reinforce habitsMovement-sensing neurons in the striatum influence a mouse’s choice of action by favoring routine behaviors. 2288
Reposted by Ole Christian SylteUte Häussler @ute-fr.bsky.social · 20/05/2025A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations. #TrEPILab www.sciencedirect.com/science/arti...sciencedirect.comLong-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic miceMesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy characterized by seizures originating from the hippocampus and adjacent reg… 084
Reposted by Ole Christian SylteAntje Kilias @antjekilias.bsky.social · 18/05/2025Looking forward to an exciting Spring Hippocampal Research Conference in Verona with @mbartos.bsky.social @olechsylte.bsky.social @federicotorelli.bsky.social and @ute-fr.bsky.social 1113
Reposted by Ole Christian SylteHugo Spiers @hugospiers.bsky.social · 15/05/2025Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social www.nature.com/articles/s41...nature.comDopaminergic action prediction errors serve as a value-free teaching signal - NatureDopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum. 04622
Reposted by Ole Christian SylteSainsbury Wellcome Centre @sainsburywellcome.bsky.social · 14/05/2025Read the full paper ‘Dopaminergic action prediction errors serve as a value-free teaching signal’ in @natureportfolio.nature.com @gatsbyucl.bsky.social @imperialcollegeldn.bsky.social www.nature.com/articles/s41...nature.comDopaminergic action prediction errors serve as a value-free teaching signal - NatureDopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum. 084
Reposted by Ole Christian Syltein-code.bsky.social @in-code.bsky.social · 30/04/2025Congrats to Aurore Gazala for winning the Eve Marder Best Paper Prize for “Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice” (Nat Comm, 2024) - awarded in person by Eve Marder at the IN-CODE retreat in Potsdam! @acazala.bsky.social #interneurons 093
Reposted by Ole Christian SylteEelke Snoeren @eelkesnoeren.bsky.social · 25/04/2025Play the "IBNS 2025 Reindeer Games Contest"! Share one of the reindeer adds on social media and get the most likes! @ibnsconnect.bsky.social 1st prize - $100 Gift Card or $200 off IBNS Registration 2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership 021
Ole Christian Sylte @olechsylte.bsky.social · 25/04/2025Don't miss your last chance to attend IBNS in Tromsø! 030
Reposted by Ole Christian SylteAurore Cazala @acazala.bsky.social · 17/04/2025🔬🤝🎨 Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️ 151
Reposted by Ole Christian SylteMarlene Bartos @mbartos.bsky.social · 12/03/2025Check our new manuscript on ‚Coordinated representational drift supports stable place coding in the hippocampal CA1’ by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer. www.biorxiv.org/content/10.1...biorxiv.orgCoordinated representational drift supports stable place coding in hippocampal CA1The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh... 0145
Reposted by Ole Christian SylteJonas Sauer @jf-sauer.bsky.social · 11/03/2025New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah! www.cell.com/cell-reports...cell.comConjoint generalized and trajectory-specific coding of task structure by prefrontal neuronsNeurons in the medial prefrontal cortex (mPFC) show spatially modulated activities. Muysers et al. show that mPFC neurons fall into distinct functional classes that differ in terms of their spatial tu... 183
Reposted by Ole Christian SylteLiset M. de la Prida @lmprida.bsky.social · 26/02/2025New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social 49032
Reposted by Ole Christian SylteAurore Cazala @acazala.bsky.social · 23/02/2025Slow life as a scientist 032
Reposted by Ole Christian SylteChunyu Ann Duan @annduan.bsky.social · 16/02/2025First preprint from our lab! An @jerlich.bsky.social collaboration We developed novel frameworks to study multi-agent decisions in mice. Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information! www.biorxiv.org/content/10.1...biorxiv.orgMice dynamically adapt to opponents in competitive multi-player gamesCompeting for resources in dynamic social environments is fundamental for survival, and requires continuous monitoring of both 'self' and 'others' to guide effective choices. Yet our understanding of ... 28622
Ole Christian Sylte @olechsylte.bsky.social · 10/02/2025Don't miss the chance to present at the world's northernmost university city while catching the midnight sun 👇 010
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics. New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇biorxiv.orgCoordinated representational drift supports stable place coding in hippocampal CA1The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh... 1144
Reposted by Ole Christian SylteEelke Snoeren @eelkesnoeren.bsky.social · 22/01/2025New paper alert! We studied the temporal copulatory patterns of female rat sexual behavior and proposed a new behavioral assessment method. #behavioralneuroscience #UiTtheArcticUniversityofNorway #neuroscience www.sciencedirect.com/science/arti...sciencedirect.comThe temporal copulatory patterns of female rat sexual behaviorFemale sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulatin… 062
Reposted by Ole Christian SylteUte Häussler @ute-fr.bsky.social · 20/01/2025Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse. 142
Ole Christian Sylte @olechsylte.bsky.social · 17/01/2025If you're into behavioral neuroscience and/or machine learning and looking for a postdoc, check this out - excellent lab and mentor! 👇 011
Ole Christian Sylte @olechsylte.bsky.social · 17/01/2025Having spent 4+ years in @jf-sauer.bsky.social lab - this is a fantastic opportunity! Great mentor & super exciting work on neural population code! 020
Reposted by Ole Christian SylteMohamady El-Gaby @melgaby.bsky.social · 25/11/2024A bit late to the Bluesky party but here’s our work showing a coordinate system for behavioural space, and an algorithm for computing behavioural sequences in the mFC: www.nature.com/articles/s41...nature.comA cellular basis for mapping behavioural structure - NatureMice generalize complex task structures by using neurons in the medial frontal cortex that encode progress to task goals and embed behavioural sequences. 0278