Sign in

Ole Christian Sylte

@olechsylte.bsky.social
170 followers 154 following 16 posts

Neuroscientist, postdoc in Stephenson-Jones lab at Sainsbury Wellcome Centre, UCL

PostsRepliesMedia
Reposted by Ole Christian Sylte
Rob Campbell @raacampbell.com · 04/10/2026
Preprint is out! Our BakingTray software turns a 2-photon microscope into a serial-section tomography system for automated whole-organ imaging. ~€35k to convert an existing scope. 11 systems worldwide, >7,000 samples at SWC alone #neuroskyence #microscopy www.biorxiv.org/content/10.6...
A BrainSaw at the Max Planck Institute for Brain Research, Frankfurt. A Nikon 16x water-immersion objective on a 400 µm travel PIFOC allows for fast z-stacks. Samples are imaged and cut in the clear water bath. A Leica VT1000 vibratome is seen to the right with a mounted blade.How BrainSaw works. Samples are embedded in an agarose block, which is glued to a slide and clamped into a water bath. The bath sits on a three-axis stage under a 2-photon microscope; the stage moves the sample for both tile scanning and slicing. The microscope images the exposed face of the block, the vibratome cuts off the imaged layer, and the cycle repeats until the samples have been fully imaged. Data are stitched automatically and are ready for downstream analysis. Logos below: BrainSaw (hardware), BakingTray (acquisition software), StitchIt (stitching).Coronal section of an Sst-tdTomato mouse brain imaged on BrainSaw. tdTomato-expressing cells are shown in yellow, scattered through cortex and hippocampus; tissue autofluorescence is shown in blue.Coronal section of a mouse brain with three neighbouring viral injections targeting layer 5 of V1, expressing mCherry (red), eGFP (green) and BFP (blue). The thick apical dendrites of the labelled neurons are clearly visible, as are their axons projecting to distant targets. Image credit: Alex Fritzl.
49131
Reposted by Ole Christian Sylte
Masahiro Nakano @masahironakano.bsky.social · 19/09/2026
My first paper has been published in Hippocampus! bsky.app/profile/masa... Thank you Caswell and Claudia for your support!
bsky.app
25010
Reposted by Ole Christian Sylte
Adrian Roggenbach @a-roggenbach.bsky.social · 24/08/2026
⚠️PREPRINT ALERT⚠️ How can we better understand distributed brain activity across temporal and spatial scales? In this collaborative project, we combined ultra-flexible electrodes with two-photon imaging to illuminate brain-wide neural dynamics. Link: doi.org/10.21203/rs.... 1/8
13311
Reposted by Ole Christian Sylte
Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 07/07/2026
@neuroweiler.bsky.social, @olechsylte.bsky.social and Matilda Cloves are presenting posters tomorrow (8 July) 🙌
111
Reposted by Ole Christian Sylte
Nora Roüast @norarouast.bsky.social · 26/06/2026
Ever wondered what having auditory stimulation does to the sleep itself? Random stimulation disturbs SWS, memory, and travelling dynamics of slow waves. New paper in iScience with @mschoenauer.bsky.social, @denizkumral.bsky.social, and Steffen Gais! doi.org/10.1016/j.is... #sleep #neuroskyence
doi.org
Redirecting
1177
Reposted by Ole Christian Sylte
in-code.bsky.social @in-code.bsky.social · 24/06/2026
Fantastic news for IN-CODE! Prof. Marlene Bartos (Uni Freiburg) secured a €2.5M ERC Advanced Grant for "ReMember-CA3". Her team will investigate how the hippocampal CA3 circuit encodes memories without overwriting old ones, and how it retrieves them over extended periods of time. #ERC #Neuroscience
0165
Reposted by Ole Christian Sylte
Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 11/05/2026
Calling all neuroscience postdocs! Come and share your work with the London neuroscience community. No CVs, publication records or recommendation letters needed. Learn more about SWC’s Emerging Neuroscientists Seminar Series and apply by 30 June: www.sainsburywellcome.org/web/content/...
Quote from Dr Saurabh Vyas, 2025 ENSS Speaker: “I think it's a terrific experience. You get to engage with the community at SWC, and I think it's super valuable.”
01813
Reposted by Ole Christian Sylte
Eelke Snoeren @eelkesnoeren.bsky.social · 21/04/2026
Latest article from the lab is out: "Behavioral dynamics of different stages of sexual motivation in male and female rats".
sciencedirect.com
Behavioral dynamics of different stages of sexual motivation in male and female rats
Sexual motivation is a complex concept involving both the initial drive to begin mating and the motivation to sustain copulation. Disruptions in sexua…
062
Reposted by Ole Christian Sylte
Thibault Cholvin @thibaultcholvin.bsky.social · 30/03/2026
I’m happy to share our new paper (with @mbartos.bsky.social) now out in Nature Neuroscience: "The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations" Download it @ rdcu.be/famDE More below 🧵
12610
Reposted by Ole Christian Sylte
Kristine Heiney, PhD @krisheiney.bsky.social · 05/03/2026
Out now in @plos.org CB: doi.org/10.1371/jour... Neural representations of tasks change over time, even in the absence of changes in task performance. But neurons change tuning at different rates. How does a neuron's stability relate to its interactions with the population? #compneuro #neuroskyence
doi.org
Information theoretic measures of neural and behavioural coupling predict representational drift
Author summary Activity in the brain represents information about the outside world and how we interact with it. Recent evidence shows that these representations slowly change day to day, while memori...
15418
Reposted by Ole Christian Sylte
Athena Akrami @athenaakrami.bsky.social · 16/02/2026
Thrilled to finally share this work! 🧠🔊 Using a new reinforcement-free task we show mice (like humans) extract abstract structure from sound (unsupervised) & dCA1 is causally required by building factorised, orthogonal subspaces of abstract rules. Led by Dammy Onih! www.biorxiv.org/content/10.6...
biorxiv.org
315752
Reposted by Ole Christian Sylte
Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 12/02/2026
Congratulations to @olechsylte.bsky.social on receiving a Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship! 🎉 Ole will investigate how the brain transforms spatial knowledge into goal-directed actions.
“I'm excited to start this fellowship at the Sainsbury Wellcome Centre, studying how the brain turns knowledge of where you are into decisions about where to go next.” – Dr Ole Christian Sylte
1102
Ole Christian Sylte @olechsylte.bsky.social · 18/01/2026
Congratulations Adrian!🎉
000
Reposted by Ole Christian Sylte
Chunyu Ann Duan @annduan.bsky.social · 14/12/2025
New preprint from the lab! A frontal motor circuit for economic decisions and actions: www.biorxiv.org/content/10.6... We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
biorxiv.org
A frontal motor circuit for economic decisions and actions
Flexible behaviour requires transforming abstract cognitive representations, such as value preferences, into concrete motor actions. During economic decision-making, individuals evaluate options to gu...
57724
Reposted by Ole Christian Sylte
Nora Jamann @norajamann.bsky.social · 04/12/2025
Please share! 🧠 Opportunity for a PhD position: Studying interneurons and memory, using cutting-edge techniques, such as patch-clamp electrophysiology, in vivo calcium imaging, optogenetics and behavioral experiments. Interested? Have a look here for more information: www.fens.org/careers/job-...
fens.org
PhD student (f/m/d) - Interneurons and memory - Federation of European Neuroscience Societies
065
Reposted by Ole Christian Sylte
Aurore Cazala @acazala.bsky.social · 27/10/2025
Now that the science days are over, I can happily share some of my designs :) Thanks to all the @in-code.bsky.social members who made these days a success! It was intense but worth it! And huge thanks to @sophiekb.bsky.social that was in charge of making this happen
053
Reposted by Ole Christian Sylte
Gatsby Computational Neuroscience Unit @gatsbyucl.bsky.social · 25/09/2025
🙋Are you interested in bridging theory & experiments? Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme. Join us and be part of a vibrant research community! 💰 Fully-funded 4-year programme ℹ️ www.ucl.ac.uk/life-science... @sainsburywellcome.bsky.social
01610
Reposted by Ole Christian Sylte
Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 23/09/2025
Applications are now open for the SWC Systems Neuroscience PhD Programme. Join us in London! 🧠 World-class neuroscience training 💰 Fully-funded 4-year programme 🖥️ Close links to @gatsbyucl.bsky.social Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
23223
Reposted by Ole Christian Sylte
Eelke Snoeren @eelkesnoeren.bsky.social · 14/08/2025
🚨New paper alert! We studied the long-term consequences of SSRI use during pregnancy on the offspring in rats in a seminatural environment. We found that perinatal FLX exposure significantly increases sexual behavior in adult male rats. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyence
sciencedirect.com
Perinatal fluoxetine exposure increases male rat sexual behavior
Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to pregnant women due to their efficacy and safety profile, leading to potenti…
062
Reposted by Ole Christian Sylte
Jens-Bastian Eppler @j-b-eppler.bsky.social · 04/08/2025
And for me the big question is: What about representational drift? 😄 Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense? How can perception stay stable if the neurons keep changing? I’m sure manifolds will help us understand that too… 🧠🧪 3/3
251
Reposted by Ole Christian Sylte
Eelke Snoeren @eelkesnoeren.bsky.social · 07/07/2025
🚨 New Article Alert! 🚨 Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence @uitnorgesarktiske.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats
The brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, charact…
274
Reposted by Ole Christian Sylte
Eelke Snoeren @eelkesnoeren.bsky.social · 31/05/2025
New preprint alert! Perinatal fluoxetine exposure increases male rat sexual behavior. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyence
131
Reposted by Ole Christian Sylte
The Transmitter @thetransmitter.bsky.social · 11/06/2025
A non-value-based system in the brain automates decision-making and frees up cognitive resources for other tasks, a new study in mice suggests. By Holly Barker #neuroskyence www.thetransmitter.org/neurobiology...
thetransmitter.org
Dopamine neurons signal default behavior to reinforce habits
Movement-sensing neurons in the striatum influence a mouse’s choice of action by favoring routine behaviors.
2288
Reposted by Ole Christian Sylte
Ute Häussler @ute-fr.bsky.social · 20/05/2025
A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations. #TrEPILab www.sciencedirect.com/science/arti...
sciencedirect.com
Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice
Mesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy characterized by seizures originating from the hippocampus and adjacent reg…
084
Reposted by Ole Christian Sylte
Antje Kilias @antjekilias.bsky.social · 18/05/2025
Looking forward to an exciting Spring Hippocampal Research Conference in Verona with @mbartos.bsky.social @olechsylte.bsky.social @federicotorelli.bsky.social and @ute-fr.bsky.social
1113
Reposted by Ole Christian Sylte
Hugo Spiers @hugospiers.bsky.social · 15/05/2025
Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social www.nature.com/articles/s41...
nature.com
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
04622
Reposted by Ole Christian Sylte
Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 14/05/2025
Read the full paper ‘Dopaminergic action prediction errors serve as a value-free teaching signal’ in @natureportfolio.nature.com @gatsbyucl.bsky.social @imperialcollegeldn.bsky.social www.nature.com/articles/s41...
nature.com
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
084
Reposted by Ole Christian Sylte
in-code.bsky.social @in-code.bsky.social · 30/04/2025
Congrats to Aurore Gazala for winning the Eve Marder Best Paper Prize for “Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice” (Nat Comm, 2024) - awarded in person by Eve Marder at the IN-CODE retreat in Potsdam! @acazala.bsky.social #interneurons
093
Reposted by Ole Christian Sylte
Eelke Snoeren @eelkesnoeren.bsky.social · 25/04/2025
Play the "IBNS 2025 Reindeer Games Contest"! Share one of the reindeer adds on social media and get the most likes! @ibnsconnect.bsky.social 1st prize - $100 Gift Card or $200 off IBNS Registration 2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership
021
Ole Christian Sylte @olechsylte.bsky.social · 25/04/2025
Don't miss your last chance to attend IBNS in Tromsø!
030
Ole Christian Sylte @olechsylte.bsky.social · 17/04/2025
Really amazing!
010
Reposted by Ole Christian Sylte
Aurore Cazala @acazala.bsky.social · 17/04/2025
🔬🤝🎨 Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️
Mouse watching its axons
151
Reposted by Ole Christian Sylte
Marlene Bartos @mbartos.bsky.social · 12/03/2025
Check our new manuscript on ‚Coordinated representational drift supports stable place coding in the hippocampal CA1’ by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer. www.biorxiv.org/content/10.1...
biorxiv.org
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
0145
Reposted by Ole Christian Sylte
Jonas Sauer @jf-sauer.bsky.social · 11/03/2025
New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah! www.cell.com/cell-reports...
cell.com
Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons
Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities. Muysers et al. show that mPFC neurons fall into distinct functional classes that differ in terms of their spatial tu...
183
Reposted by Ole Christian Sylte
Liset M. de la Prida @lmprida.bsky.social · 26/02/2025
New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social
49032
Reposted by Ole Christian Sylte
Aurore Cazala @acazala.bsky.social · 23/02/2025
Slow life as a scientist
Drawing of a researcher performing analysis at his desk
032
Reposted by Ole Christian Sylte
Chunyu Ann Duan @annduan.bsky.social · 16/02/2025
First preprint from our lab! An @jerlich.bsky.social collaboration We developed novel frameworks to study multi-agent decisions in mice. Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information! www.biorxiv.org/content/10.1...
biorxiv.org
Mice dynamically adapt to opponents in competitive multi-player games
Competing for resources in dynamic social environments is fundamental for survival, and requires continuous monitoring of both 'self' and 'others' to guide effective choices. Yet our understanding of ...
28622
Ole Christian Sylte @olechsylte.bsky.social · 10/02/2025
Don't miss the chance to present at the world's northernmost university city while catching the midnight sun 👇
010
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
Huge thanks to co-first author @antjekilias.bsky.social for impressive experimental work, and to Marlene Bartos and @jf-sauer.bsky.social for their supervision!
010
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
How does this help downstream neurons? If drift is coordinated (preserving geometry), downstream neurons can compensate and read stable spatial maps. But if drift distorts the geometry, a downstream network fails under noise.
110
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
How can the geometry be stable while individual neurons drift? It turns out the entire population activity is gradually rotating and translating in neural state space. These two transformations can accurately account for the observed drift.
110
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
Because the internal geometry remains stable, we can align neural activity across days and recover stable spatial tuning. Crucially, this only works for coordinated drift - it fails for recovering ‘remapping’ across context or simulated uncoordinated drift.
110
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
In a new environment, internal geometry is initially unstable but gradually stabilizes with experience. This suggests that geometric stability is learned over time!
110
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
However, these changes aren’t random! Instead, the entire population shifts in a coordinated way that preserves its internal geometry - like a constellation moving across the night sky while keeping its overall shape.
110
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
To address this, @antjekilias.bsky.social (co-first author) performed multi-day 2-photon imaging of CA1 pyramidal neurons while mice navigated a virtual environment. As expected, the spatial map drift across days.
110
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
For a long time, we have been puzzled by a paradox: place cells in hippocampal CA1 are crucial for spatial navigation and memory, but their tuning drifts over time. Despite this, we remember places just fine. So how does the brain extract stable information from drifting neurons?
110
Ole Christian Sylte @olechsylte.bsky.social · 05/02/2025
Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics. New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
biorxiv.org
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
1144
Reposted by Ole Christian Sylte
Eelke Snoeren @eelkesnoeren.bsky.social · 22/01/2025
New paper alert! We studied the temporal copulatory patterns of female rat sexual behavior and proposed a new behavioral assessment method. #behavioralneuroscience #UiTtheArcticUniversityofNorway #neuroscience www.sciencedirect.com/science/arti...
sciencedirect.com
The temporal copulatory patterns of female rat sexual behavior
Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulatin…
062
Reposted by Ole Christian Sylte
Ute Häussler @ute-fr.bsky.social · 20/01/2025
Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.
142
Ole Christian Sylte @olechsylte.bsky.social · 17/01/2025
If you're into behavioral neuroscience and/or machine learning and looking for a postdoc, check this out - excellent lab and mentor! 👇
011