Sign in

Neuropsychopharmacology

@npp-journal.bsky.social
1.4K followers 123 following 1.5K posts

Neuropsychopharmacology (NPP) is an official peer-reviewed publication of the American College of Neuropsychopharmacology. We report discoveries and promote training & outreach initiatives.

PostsRepliesMedia
Neuropsychopharmacology @npp-journal.bsky.social · 22h
Impaired brain insulin signaling may be an early biomarker and target for treatment of depression www.nature.com/artic..."
nature.com
Is abnormal brain insulin action implicated in the biology of depression? A pilot neuroimaging study in adolescents
Neuropsychopharmacology - Is abnormal brain insulin action implicated in the biology of depression? A pilot neuroimaging study in adolescents
011
Neuropsychopharmacology @npp-journal.bsky.social · 07/10/2026
Microglial dysfunction and glutamatergic dysregulation may represent distinct mechanisms in schizophrenia
nature.com
Does a monoclonal antibody targeting immune cells affect glutamatergic level in schizophrenia? A multimodal PET/MRS brain imaging study
Neuropsychopharmacology - Does a monoclonal antibody targeting immune cells affect glutamatergic level in schizophrenia? A multimodal PET/MRS brain imaging study
020
Neuropsychopharmacology @npp-journal.bsky.social · 06/10/2026
#TWiNPP Dr. Jules Angst, Fellow Emeritus of ACNP, passed away on May 15, 2026
nature.com
In Memorium: Jules Angst, Prof. Dr. med. (1926 to 2026)
Neuropsychopharmacology - In Memorium: Jules Angst, Prof. Dr. med. (1926 to 2026)
000
Neuropsychopharmacology @npp-journal.bsky.social · 06/10/2026
#TWiNPP Findings from Petitgas et al. highlight choline metabolism as a potential biomarker of neurodevelopmental vulnerability and heterogeneity in bipolar disorder
nature.com
Reduced prefrontal total choline MRS levels characterize the neurodevelopmental phenotype of bipolar disorder
Neuropsychopharmacology - Reduced prefrontal total choline MRS levels characterize the neurodevelopmental phenotype of bipolar disorder
100
Neuropsychopharmacology @npp-journal.bsky.social · 06/10/2026
In this short-but-sweet installment of #ThisWeekInNPP, we highlight new insights into choline MRS levels in bipolar disorder and share a memoriam for ACNP Fellow Emeritus Dr. Jules Angst #TWiNPP
120
Neuropsychopharmacology @npp-journal.bsky.social · 06/10/2026
Brain subcompartments exhibit distinct pharmacokinetic and concentration-behavior relationships
nature.com
Pharmacokinetics and concentration-behavioral effect relationships differ between brain subcompartments
Neuropsychopharmacology - Pharmacokinetics and concentration-behavioral effect relationships differ between brain subcompartments
000
Neuropsychopharmacology @npp-journal.bsky.social · 05/10/2026
Understanding cultural humility as an essential framework for equitable and inclusive clinical practice
nature.com
Cultural humility in the teaching and practice of clinical care
Neuropsychopharmacology - Cultural humility in the teaching and practice of clinical care
031
Reposted by Neuropsychopharmacology
Matt Hill @cannabrain.bsky.social · 02/10/2026
**Recruitment** We are looking to hire a psychiatrist/scientist (MD or MD/PhD) who focuses on neuromodulation, particularly rTMS in the Department of Psychiatry at the University of Calgary. Come join myself, @mayoonthebrain.bsky.social and more. Details 👇 careers.ucalgary.ca/jobs/1829278...
careers.ucalgary.ca
Academic Position in Neuromodulation Research, Department of Psychiatry, Cumming School of Medicine in Calgary, ...
Academic Position in Neuromodulation Research, Department of Psychiatry, Cumming School of Medicine in Calgary, ...
01322
Neuropsychopharmacology @npp-journal.bsky.social · 02/10/2026
Data supporting auditory event-related potentials (ERPs) as transdiagnostic neural markers that distinguish broad psychosis liability from general psychopathology
nature.com
Auditory event-related potentials and psychosis dimensions
Neuropsychopharmacology - Auditory event-related potentials and psychosis dimensions
030
Neuropsychopharmacology @npp-journal.bsky.social · 01/10/2026
Common and unique functional brain alterations may inform transdiagnostic biomarkers and precision psychiatry
nature.com
Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders
Neuropsychopharmacology - Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders
000
Neuropsychopharmacology @npp-journal.bsky.social · 30/09/2026
Identification of the galanin-noradrenaline axis as a potential biomarker and therapeutic mechanisms underlying the antidepressant effects of psilocybin
nature.com
CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder
Neuropsychopharmacology - CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder
020
Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
#TWiNPP Tau pathology can be detected in the basal forebrain using PET imaging despite challenges, including tracer-specific off-target binding adjacent to this critical early tau-accumulating region www.nature.com/articles/s41...
nature.com
Measuring in-vivo tau pathology in the basal forebrain with PET imaging - Neuropsychopharmacology
Neuropsychopharmacology - Measuring in-vivo tau pathology in the basal forebrain with PET imaging
000
Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
#TWiNPP Here, a study identifying the dynorphin/kappa opioid receptor system as a key link between opioid withdrawal-related negative affect and relapse vulnerability www.nature.com/articles/s41...
nature.com
Kappa opioid receptor-dependent depressive-like behaviors associated with morphine withdrawal contribute to stress-induced reinstatement of morphine seeking - Neuropsychopharmacology
Neuropsychopharmacology - Kappa opioid receptor-dependent depressive-like behaviors associated with morphine withdrawal contribute to stress-induced reinstatement of morphine seeking
100
Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
#TWiNPP Next up, a Hot Topics article highlighting how comparison of symptom profiles and treatment responses in neurodegenerative disease can provide a framework for understanding the neurobiology of psychiatric symptoms and inform more targeted treatments www.nature.com/articles/s41...
nature.com
Psychiatry in neurodegenerative disease: toward a unified neurobiological framework - Neuropsychopharmacology
Neuropsychopharmacology - Psychiatry in neurodegenerative disease: toward a unified neurobiological framework
100
Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
#TWiNPP From Mandeville et al., brain imaging results providing a functional correlate of the antipsychotic therapeutic window www.nature.com/articles/s41...
nature.com
Robust changes in brain function require high D2 receptor occupancy by prochlorperazine: an imaging correlate for the antipsychotic therapeutic window - Neuropsychopharmacology
Neuropsychopharmacology - Robust changes in brain function require high D2 receptor occupancy by prochlorperazine: an imaging correlate for the antipsychotic therapeutic window
111
Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
#TWiNPP Sai et al. show that nicotine protonation shifts where inhaled nicotine is deposited, potentially contributing to distinct respiratory health risks associated with different e-cigarette formulations www.nature.com/articles/s41...
nature.com
Comparing brain absorption and lung deposition of nicotine salts and free-base e-cigarettes: insights from [11C]nicotine PET imaging - Neuropsychopharmacology
Neuropsychopharmacology - Comparing brain absorption and lung deposition of nicotine salts and free-base e-cigarettes: insights from [11C]nicotine PET imaging
121
Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
It's time for our final #ThisWeekInNPP of September and we're showing no sign of slowing down as we creep into Spooky Season 🎃👻 Read the latest on nicotine, antipsychotic medications, opioids & relationships between neurodegenerative disorders and psychiatric symptoms 👇 #TWiNPP
100
Reposted by Neuropsychopharmacology
Kira Höffler @kirahoeffler.bsky.social · 22/09/2026
very happy about this one 😊
033
Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
Noradrenergic signaling regulates hippocampal bioenergetics and contributes to spatial memory
nature.com
Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α
Neuropsychopharmacology - Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α
001
Neuropsychopharmacology @npp-journal.bsky.social · 28/09/2026
This nose-poke-restricted vapor cocaine self-administration model in mice provides the opportunity to study inhaled cocaine use and relapse models
nature.com
Development of a nose-poke restricted vaporized cocaine self-administration model in mice
Neuropsychopharmacology - Development of a nose-poke restricted vaporized cocaine self-administration model in mice
021
Neuropsychopharmacology @npp-journal.bsky.social · 25/09/2026
New findings show that the GluN2A-selective positive allosteric modulator GNE-5729 improves specific executive functions in a state-dependent manner, advancing our understanding of targeted NMDA receptor modulation
nature.com
Differential and state-dependent effects of the GluN2A-selective positive allosteric modulator GNE-5729 on executive functions
Neuropsychopharmacology - Differential and state-dependent effects of the GluN2A-selective positive allosteric modulator GNE-5729 on executive functions
000
Neuropsychopharmacology @npp-journal.bsky.social · 24/09/2026
A sex-specific hippocampal-striatal circuits controls impulsive action
nature.com
A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats
Neuropsychopharmacology - A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats
000
Neuropsychopharmacology @npp-journal.bsky.social · 23/09/2026
How does the ADHD-linked receptor latrophilin-3 (ADGRL3) regulate dopamine? Its loss increases dopamine release in brain slices but reduces it in behaving mice, suggesting ADGRL3 may control where dopamine is released rather than simply how much
nature.com
Altered striatal dopamine regulation in Adgrl3 knockout mice
Neuropsychopharmacology - Altered striatal dopamine regulation in Adgrl3 knockout mice
000
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP Ritchie et al. examine how binge alcohol drinking alters serotonin dynamics in the anterior cingulate cortex and central amygdala. Results highlight circuit-specific roles for serotonin in alcohol-related behaviors www.nature.com/articles/s41...
nature.com
Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption - Neuropsychopharmacology
Neuropsychopharmacology - Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption
041
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP This study explores how cannabis-related cues alter prefrontal neurochemistry in individuals with cannabis use disorder (CUD), highlighting cue-elicited GABA dynamics as a potential biomarker of CUD www.nature.com/articles/s41...
nature.com
Cue-elicited prefrontal gamma-aminobutyric acid (GABA) dynamics in cannabis use disorder - Neuropsychopharmacology
Neuropsychopharmacology - Cue-elicited prefrontal gamma-aminobutyric acid (GABA) dynamics in cannabis use disorder
110
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP From Meina-Saldivar et al., findings demonstrating a specific role for VTA endocannabinoid signaling in social motivation www.nature.com/articles/s41...
nature.com
Endocannabinoid metabolism at VTA GABAergic neurons gates motivation for social, but not food, reward - Neuropsychopharmacology
Neuropsychopharmacology - Endocannabinoid metabolism at VTA GABAergic neurons gates motivation for social, but not food, reward
100
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP Here, Xie & Murata et al. show that N-ethylmaleimide-sensitive factor (NSF)-D2R signaling could be a potential mechanism underlying ADHD-related phenotypes www.nature.com/articles/s41...
nature.com
Deletion of N-ethylmaleimide-sensitive factor in dopamine D2 receptor-expressing cells impairs striatal development and dopaminergic function and induces ADHD-like behaviors in mice - Neuropsychopharm...
Neuropsychopharmacology - Deletion of N-ethylmaleimide-sensitive factor in dopamine D2 receptor-expressing cells impairs striatal development and dopaminergic function and induces ADHD-like...
100
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP Resting-state fMRI data from the Human Connectome Project-Early Psychosis suggests that dynamic network measures can capture cognitive dysfunction beyond traditional functional connectivity approaches www.nature.com/articles/s41...
nature.com
Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses - Neuropsychopharmacology
Neuropsychopharmacology - Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses
100
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP Mismatch negativity (MMN) is a key biomarker of sensory-cognitive function. We find core cortical MMN components emerge only after adolescence, alongside top-down feedback. Surprisingly, depleting microglia during adolescence did not affect this development / @jordanhamm.bsky.social
nature.com
Mismatch negativity matures in adolescence and without sensitivity to microglial depletion - Neuropsychopharmacology
Neuropsychopharmacology - Mismatch negativity matures in adolescence and without sensitivity to microglial depletion
121
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP Could forgiveness help reduce transgression-related rumination in perimenopausal depression? This Hot Topic presents a testable socio-affective framework and identifies hormonal, frontocingulate, and GABAergic measures as exploratory www.nature.com/articles/s41...
nature.com
Forgiveness and transgression-related rumination in perimenopausal depression: a testable socio-affective hypothesis - Neuropsychopharmacology
Neuropsychopharmacology - Forgiveness and transgression-related rumination in perimenopausal depression: a testable socio-affective hypothesis
100
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP In this Hot Topics article, patient-derived iPSC neuron models can capture functional differences between responders and non-responders, advancing personalized treatments for depression www.nature.com/articles/s41...
nature.com
Functional precision psychiatry: iPSC-derived neurons as predictive assays for antidepressant response - Neuropsychopharmacology
Neuropsychopharmacology - Functional precision psychiatry: iPSC-derived neurons as predictive assays for antidepressant response
100
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP Next, a Research Highlight illustrating how stress-related signals can engage endogenous cannabinoid pathways to regulate pain following injury www.nature.com/articles/s41...
nature.com
Endocannabinoid control of the pain–stress axis - Neuropsychopharmacology
Neuropsychopharmacology - Endocannabinoid control of the pain–stress axis
100
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP In a large epigenetic study of psychotherapy response in OCD, baseline, stable, & longitudinal DNA methylation signals were associated with clinical improvement; many of them were genetically influenced. Findings highlight trait-like markers and dynamic change / @kirahoeffler.bsky.social
nature.com
Epigenetic markers of response to psychotherapy in obsessive-compulsive disorder - Neuropsychopharmacology
Neuropsychopharmacology - Epigenetic markers of response to psychotherapy in obsessive-compulsive disorder
121
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP From Prasad et al., evidence that the renin-angiotensin system may modulate depression-relevant emotional biases www.nature.com/articles/s41...
nature.com
Acute effects of AT1 receptor blockade on approach-avoidance of negative emotional faces - Neuropsychopharmacology
Neuropsychopharmacology - Acute effects of AT1 receptor blockade on approach-avoidance of negative emotional faces
100
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
#TWiNPP
110
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
Welcome back to another 2-page installment of #ThisWeekInNPP 🤩 See below for 11 (‼️) of the newest insights across all spectrums of neuropsychopharmacology research 💊 #TWiNPP
130
Reposted by Neuropsychopharmacology
Anthony Ramnauth @philoneurosci.bsky.social · 22/09/2026
Congratulations @jorge-miranda.bsky.social!! Cool that you're last author!
151
Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
This study identfied circuit-specific mechanism through which top-down cortical controls supports sustained attention, potentially informing treatments for attentional deficits
nature.com
Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)
Neuropsychopharmacology - Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)
051
Neuropsychopharmacology @npp-journal.bsky.social · 21/09/2026
Sex-specific neuroadaptations within dorsal striatal circuits underlie habitual alcohol seeking
nature.com
Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner
Neuropsychopharmacology - Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner
032
Neuropsychopharmacology @npp-journal.bsky.social · 18/09/2026
The histone variant splice isoform macroH2A1.1 is a specialized epigenetic regulator of memory consolidation
nature.com
Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation
Neuropsychopharmacology - Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation
011
Neuropsychopharmacology @npp-journal.bsky.social · 17/09/2026
This commentary discussing the importance of systems-level approaches in interpreting kappa opioid receptor function
nature.com
Kappa opioid receptors mediate aversion—and it matters
Neuropsychopharmacology - Kappa opioid receptors mediate aversion—and it matters
021
Neuropsychopharmacology @npp-journal.bsky.social · 16/09/2026
This double-blind RCT combines amisulpride administration and cerebral blood flow measurement in both healthy adults and patients with MDD to highlight the ventral striatum as a potential target for anhedonia
nature.com
Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study
Neuropsychopharmacology - Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study
000
Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
Recent advances in preclinical and clinical studies support an individual-differences framework of addiction and highlight reward sensitivity as a key driver of vulnerability
nature.com
Recent advances in individual differences in addiction neuroscience in animal models and clinical studies
Neuropsychopharmacology - Recent advances in individual differences in addiction neuroscience in animal models and clinical studies
033
Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
In a previous post, we included a mistaken tag - we apologize for the error! See our corrected post here👇 Data from Marsh et al. suggest that reinforcer availability and consumption may shape cocaine choice more strongly than temporal patterns of drug intake #TWiNPP www.nature.com/articles/s41...
nature.com
Intermittent and extended cocaine access attenuate cocaine-vs-food choice in male and female rats - Neuropsychopharmacology
Neuropsychopharmacology - Intermittent and extended cocaine access attenuate cocaine-vs-food choice in male and female rats
000
Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
That's (f)all for this week! See you next week for #TWiNPP!
static.klipy.com
Happy Dog Jumps into a Pile of Autumn Leaves
ALT: Happy Dog Jumps into a Pile of Autumn Leaves
100
Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
Robert Bruce Lydiard, Member Emeritus of ACNP, passed away on May 25, 2026 www.nature.com/articles/s41...
nature.com
In Memorium: Robert Bruce Lydiard, Ph.D., M.D. - Neuropsychopharmacology
Neuropsychopharmacology - In Memorium: Robert Bruce Lydiard, Ph.D., M.D.
100
Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
Another Hot Topics article, this one highlighting psilocybin as a promising treatment for anxiety disorders www.nature.com/articles/s41...
nature.com
Psilocybin as an emerging anxiolytic: mechanisms, evidence, and open questions - Neuropsychopharmacology
Neuropsychopharmacology - Psilocybin as an emerging anxiolytic: mechanisms, evidence, and open questions
000
Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
From King et al., menstrual cycle-dependent brain changes may contribute to individual differences in addiction and craving www.nature.com/articles/s41...
nature.com
Menstrual cycle-dependent white matter microstructural dynamics in women with substance use disorder - Neuropsychopharmacology
Neuropsychopharmacology - Menstrual cycle-dependent white matter microstructural dynamics in women with substance use disorder
100
Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
Mott et al. identify the lateral habenula as a neural correlate of competitive social behavior @melissaherman.bsky.social www.nature.com/articles/s41...
nature.com
Complex social dominance behavior using a novel platform test is associated with lateral habenula activation in male and female mice - Neuropsychopharmacology
Neuropsychopharmacology - Complex social dominance behavior using a novel platform test is associated with lateral habenula activation in male and female mice
121
Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
Next, a Hot Topics article supporting TMS targeting of the frontopolar cortex to develop more precise symptom-specific treatments, particularly for substance use disorders @vincentcostaphd.bsky.social @jeremyhogeveen.bsky.social www.nature.com/articles/s41...
nature.com
Translating macaque frontopolar cortex discoveries into psychiatric treatments - Neuropsychopharmacology
Neuropsychopharmacology - Translating macaque frontopolar cortex discoveries into psychiatric treatments
100