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Noah Turner

@noahnturner.bsky.social

Structural and molecular biologist (www.jic.ac.uk/people/noah-turner) Postdoc in Michael Webster's group @ John Innes Centre, Norwich PhD in David Barford's group @ MRC LMB Interested in chloroplast evolution and gene expression

Posts Replies Media

Reposted by Noah Turner

bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/08/2026

Mechanism and regulation of Bim1 interactions withthe S. cerevisiae outer kinetochore Ndc80 complex www.biorxiv.org/content/10.64898/20…

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Reposted by Noah Turner

cryoEM papers @cryoempapers.bsky.social · 13/05/2026

Models for the architecture of the human inner kinetochore on centromeric α-satellite CENP-A nucleosome arrays pubmed.ncbi.nlm.nih.gov/42120391/ #cryoEM

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Reposted by Noah Turner

NoCaSS @nocassofficial.bsky.social · 12/04/2026

The Norwich Cambridge Science Symposium is back this summer! Save the date (13th-14th August). Check out our updated website : nocass.org, and follow @nocassofficial.bsky.social for upcoming updates on keynote speakers, panelists and workshops! (Registration opens 1st June).

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Reposted by Noah Turner

Journal of Cell Biology @jcb.org · 17/04/2026

Assembly and phospho-regulatory mechanisms of the budding yeast outer #kinetochore KMN complex. New study from Noah N. Turner (@noahnturner.bsky.social), David Barford and colleagues @mrclmb.ac.uk: rupress.org/jcb/article/... #CellDivision #StructuralBiology #kinetochores #centromeres #cryoEM

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Reposted by Noah Turner

Journal of Cell Biology @jcb.org · 10/04/2026

@noahnturner.bsky.social, Barford et al reveal conserved underlying mechanisms of complex assembly, auto-inhibition, & phosphoregulation that ensure precise control of KMN assembly onto #centromeres to enable genome division. rupress.org/jcb/article/... #kinetochores #cryoEM #biochemistry #genetics

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Noah Turner @noahnturner.bsky.social · 10/04/2026

This long, challenging project would not have been possible without the insight and experimental work of my co-authors Ziguo Zhang, Jing Yang, Kyle Muir, Stephen McLaughlin (@lmbbiophysics.bsky.social), Tomos Morgan and my PhD supervisor, David Barford. Thanks to everyone involved!

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Noah Turner @noahnturner.bsky.social · 10/04/2026

Our work reveals conserved principles that could not be previously discerned by which the KMN complex assembles and functions in humans and yeast.

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Noah Turner @noahnturner.bsky.social · 10/04/2026

We found many interfaces that hold the budding yeast complex together and regulate its assembly onto chromosomes have diverged from those that serve these functions in humans. Despite this, the architecture and functional principles of the human and budding yeast complexes are strikingly similar.

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Noah Turner @noahnturner.bsky.social · 10/04/2026

We therefore used biochemistry, biophysics and AlphaFold predictions to further clarify the molecular mechanisms by which the budding yeast KMN complex functions.

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Noah Turner @noahnturner.bsky.social · 10/04/2026

To investigate this fascinating and complex machine, we analysed the structure of reconstituted budding yeast KMN complexes using cryo-EM. Our cryo-EM density maps were limited to a maximum resolution of 4.2 Å, which we could only obtain by utilising Blush regularization implemented in RELION 5.0.

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Noah Turner @noahnturner.bsky.social · 10/04/2026

When assembled onto DNA, the eukaryote-specific kinetochore grabs on to shrinking microtubules to power chromosome segregation during mitosis. When this process goes awry, cells inherit an incomplete copy of the genome and can become sick or die.

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Noah Turner @noahnturner.bsky.social · 10/04/2026

Happy to see our paper describing cryo-EM structures of the budding yeast KMN kinetochore complex published in @jcb.org! Our structure reveals how an important hub mediates and regulates assembly of the machine that segregates chromosomes. #cryo-EM @mrclmb.ac.uk 🔗 rupress.org/jcb/article/...

Composite cryo-E M density map of the yeast K M N junction complex, showing the structure and interactions of K M N junction complex.

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