njmicrobe.org
Cut the Kinase, Break the Resistance
Review written by: Megan MaurielloCandida glabrata, now officially known as Nakaseomyces glabratus (Takashima and Sugita 2022), causes opportunistic infections, especially in immunocompromised people, and has a high mortality rate. It is among the most frequently antifungal-resistant Candida species. Echinocandin antifungals, including caspofungin, micafungin, anidulafungin, and rezafungin, inhibit fungal cell wall synthesis by inhibiting β-1,3-glucan synthase. Echinocandin resistance is usually