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NIAGADS - National Alzheimer's Database

@niagads.bsky.social
74 followers 218 following 47 posts

We are a database that stores and distributes genetics and genomics data from studies on Alzheimer’s disease, related dementias, and aging globally Follow us for breaking Alz news, research studies, and datasets in the database

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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 30/09/2026
Join us at the 15th #ISFTD International Conference in Philadelphia next week to learn how datasets from NIAGADS can help advance your FTD research! Look for us at Booth 4TT on Oct 8-10 (Thur-Sat). Our first session will be Thursday 12-7. Hope to see you there!
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Alzheimer's Association @alzassociation.bsky.social · 12/07/2026
"We've given people reasons to raise their expectations for what's possible. Together, we will deliver on those expectations, for everyone. You have our commitment. We will always stand up for you. And for science.” Our President & CEO Joanne Pike, DrPH, welcomes researchers to #AAIC26.
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
NIAGADS has a lot to offer, check out our 2026 update poster created by our associate director of operations Amanda Kuzma in the exhibit hall at 3382. #AAIC26
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
Today in the exhibit hall, speaker Anita Destefano will be giving a talk on the ADSP: Data Highlights and Insights at Booth 901 #AAIC26 Learn about the genomic and phenotypic data available via the ADSP. Current data and future plans will be presented.
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
Today in the exhibit hall, our research project manager, Heather White will be giving a talk on open access data resources from NIAGADS genetic and genomic data for Alzheimer's Disease (AD), AD related dementia, and healthy aging. Checko ut our booth if you haven't yet. #AAIC26
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
Yesterday in the exhibit hall, NIAGADS researcher, Yuk Yee Leung, gave a talk titled: Aging-Brain xQTLs Actionable: The FunGen Atlas and Portal. #AAIC26 She discussed harmonized multi-omic brain xQTLs from ROSMAP, MSBB, Knight-ADRC, and more.
leung.making
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
In a session yesterday at #AAIC26, participants learned about NIAGADS and how to access qualified genetic and genomic data for Alzheimer's Disease (AD), AD-related dementia, and healthy aging
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
Yesterday, NIAGADS PI Li-San Wang and other investigators from the ADSP networked with other researchers in a dedicated space designed for connection and collaboration #AAIC26
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
On Sunday, we partnered with Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) teams for an in-person workshop exploring harmonized biomarker data along with other rich genetic and genomic data available from the ADSP data ecosystem on NIAGADS
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
On Sunday, we partnered with Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) teams for an in-person workshop exploring harmonized biomarker data along with other rich genetic and genomic data available from the ADSP data ecosystem on NIAGADS
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
We know you haven't seen everything at #AAIC26 yet. Join us for our scavenger hunt to learn more about how our services can benefit you niagads-scavenger-hunt.stre...
niagads-scavenger-hunt.streamlit.app
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 14/07/2026
#AAIC26 isn't over yet. Visit the participating members of the NIH Pavilion to learn how AD and ADRD repositories and studies can support your resources. Visit all the booths, collect stamps, and enter to win a prize!
yet.visit
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Ian Kremer @wolverinebear.bsky.social · 26/06/2026
4 Myths about Alzheimer’s You Need to Stop Believing www.eatingwell.com/myths-about-... #Alzheimers #dementia #health #wellness
eatingwell.com
4 Myths about Alzheimer’s You Need to Stop Believing
A neurologist breaks down 4 common myths about Alzheimer’s disease, including who gets it, what causes it and how it may be treated.
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Ian Kremer @wolverinebear.bsky.social · 25/06/2026
Study finds estrogen-based hormone therapies could protect brain health in older women news.ku.edu/news/article... #Alzheimers #dementia #WomensHealth #science
news.ku.edu
Study finds estrogen-based hormone therapies could protect brain health in older women
Click for more on research in NeuroImage
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Giulio Maria Pasinetti, MD, PhD @giuliompasinetti.bsky.social · 06/06/2026
Study by Masaya Kumamoto, Toshiharu Ninomiya, et al., from Kyushu University & RIKEN, examines whether favorable modifiable risk factors can lower #Dementia risk even among individuals w/ high genetic susceptibility. @alzassociation.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com
APOE ε4, modifiable risk factors, and dementia in community‐based older Japanese adults
INTRODUCTION Apolipoprotein E (APOE) ε4 is a major genetic risk factor for dementia. We examined whether APOE ε4 genotype modified the associations between a modifiable risk factor (mRF) score and d.....
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Stein Institute for Research on Aging @healthyagingucsd.bsky.social · 02/06/2026
June is Alzheimer’s & Brain Awareness Month. Nearly 7 million Americans are living with Alzheimer’s disease, underscoring the importance of research, education, and support for individuals and families affected by dementia. 💜 #ENDALZ #BrainAwarenessMonth #UCSDHealthyAging
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Oden @oden-gjallarhornet.bsky.social · 02/06/2026
Women's #Dementia Risk May Be Shaped by These Key Factors, Study Finds www.sciencealert.com/womens-demen...
sciencealert.com
Women's Dementia Risk May Be Shaped by These Key Factors, Study Finds
A life that leads to dementia can take many paths, but there are some common risk factors that make a diagnosis more likely.
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The Association For Frontotemporal Degeneration @theaftd.bsky.social · 21/05/2026
🧬Several genes have been linked to FTD, but it’s not always possible to predict how the disease will develop based on a specific gene. Understanding genetics can help individuals and families make more informed decisions. 🔗 Learn more about FTD and genetics here: bit.ly/3QZuTrD
An informative graphic titled "Genes That Cause FTD" explaining that genetic variants causing FTD affect protein function and brain cells. It highlights three main genes: C9orf72, MAPT, and GRN (progranulin). The AFTD logo is at the bottom, with an arrow and text indicating "Swipe to learn more." The background features a network-like design with dots and lines.The image contains text about the C9orf72 gene, associated with genetic FTD and ALS. It explains that this gene can have up to 24 repeats normally, but in FTD or ALS, the repeats occur more often, possibly leading to harmful protein buildup. It notes that predicting development of FTD, ALS, or both from this genetic change is not possible. There is a background design with abstract network lines and the AFTD logo at the bottom.An informative graphic titled "GRN (Progranulin)" explains that the GRN gene aids in making the protein progranulin, which supports cell health and controls inflammation. Changes in the GRN gene can lower progranulin levels, leading to abnormal protein buildup in the brain. Researchers are still working to understand how these changes relate to FTD. The AFTD logo is at the bottom. A swipe arrow points to the right for more information.Infographic titled "MAPT (Microtubule-associated protein tau)." Explains that the MAPT gene helps stabilize brain cells and that changes in the gene can lead to abnormal tau build-up, linked to FTD. Includes AFTD logo at the bottom.
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The Irish Times @irishtimes.com · 28/05/2026
‘FTD brothers’ complete 32 marathons in 32 days across Ireland in aid of dementia research
irishtimes.com
‘FTD brothers’ complete 32 marathons in 32 days across Ireland in aid of dementia research
Jordan and Cian Adams, whose mother Geraldine died of frontotemporal dementia which they carry the gene for, raise over €1.8m
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Miguel Minaya, Ph.D @miguelminaya.bsky.social · 06/05/2026
1/8 What if your cells are already trying to fight tau aggregation, but a broken gene stops them? 🧠⚡Our new work from @WUSTLmed identifies NINL as a novel regulator of tau aggregation in FTD and AD Full paper 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Thread 🧵👇 #Neuroscience #WUSM
alz-journals.onlinelibrary.wiley.com
Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation
INTRODUCTION Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poor...
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Anders M Fjell @andersfjell.bsky.social · 14/10/2025
@nature.com made a news piece on our new @pnas.org paper. Good job Anne Ravndal! Men’s brains shrink faster than women’s: what that means for Alzheimer’s. www.nature.com/articles/d41...
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Irene Gallego Romero @ee-reh-neh.bsky.social · 28/02/2026
Finally, today's offering! www.biorxiv.org/content/10.6... This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social
biorxiv.org
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 01/06/2026
This wonderful write-up paints a cellular picture of tau clearance, and tanycytes' possible role in preventing Alzheimer's Disease Also add a comment with: “Original article in Cell Press Blue: doi.org/10.1016/j.cp...
doi.org
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 01/06/2026
While it's well-known that eQTLs can vary based on source tissue, this review by Gilad and Battle shows some interesting examples of how diet, immune response, and even cell stress can influence eQTL significance
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National Center for Health Research @nc4hr.bsky.social · 29/05/2026
#FDA has approved blood tests for healthy people to predict whether people have a gene that may predict future #Alzheimers disease — even though the tests are far less accurate for people who are not showing signs of Alzheimer's. www.levernews.com/the-campaign...
levernews.com
The Campaign To Turn Healthy People Into Alzheimer’s Patients
Drugmakers, influencers, and industry-funded advocacy groups are pushing Alzheimer’s screenings that could label millions of Americans as sick — despite shaky science and dangerous treatments.
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GenomeWeb @genomeweb.bsky.social · 28/05/2026
Researchers in Taiwan Suggest a New CA19-9 Threshold Could Identify High-Risk Pancreatic Cancer
ebx.sh
Researchers in Taiwan Suggest a New CA19-9 Threshold Could Identify High-Risk Pancreatic Cancer
Some patients have a mutation that causes them to not produce CA19-9, a tumor marker often used to help determine prognosis.
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National Alzheimer's Coordinating Center @naccdata.org · 28/05/2026
Looking to analyze NACC data? Don’t miss AD Workbench, a data sharing and analytics environment from the Alzheimer's Disease Data Initiative! This platform is both free and user-friendly, empowering researchers across the globe to analyze data. Get started at www.alzheimersdata.org/ad-workbench!
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#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 29/05/2026
Plasma Proteomic Profiling Reveals Divergent Molecular Pathways in Aging and Alzheimer’s Disease #NeuroDegeneration 🧪🧠 www.researchsquare.com/article/rs-9…
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 01/04/2026
Are you an investigator with opinions about data integration and sharing? Come to our webinar discussing how we can improve NIAGADS for users Register at luma.com/j5bhdcsg
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Gen Wojcik @genandgenes.bsky.social · 04/03/2026
Are you interested in understanding how social and structural determinants of health influence estimates of genetic risk? Looking for figures for teaching these concepts? Check out our work on considerations for modeling them together, led by Sara Cromer and Dave Conti with @prsmethods.bsky.social
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 17/02/2026
The genetics of Black Americans often goes unstudied when looking at Alzheimer's. This #GWAS now available in DSS looked at almost 10,000 participants, using SNPTEST to find genetic variants in people with African ancestry. #genomics dss.niagads.org/datasets/ng...
dss.niagads.org
NG00179 - AD GWAS in participants of African ancestry – Ray et al., 2024 - DSS NIAGADS
The p-value only files are available in the “Open Access Dataset” tab.To access the full data, please log into DSS and submit an application.Within the application, add this dataset (accession NG00179) in the “Choose a Dataset” section.Once approved,
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 10/02/2026
Dataset from ADRC looks at people with pre symptomatic #Alz, people with #LewyBodies and #FTD. Data includes sequencing information and phenotype profiles dss.niagads.org/datasets/ng...
dss.niagads.org
NG00168 - Plasma Small RNA Transcriptomics for AD and Related Dementias - DSS NIAGADS
To access this data, please log into DSS and submit an application.Within the application, add this dataset (accession NG00168) in the “Choose a Dataset” section.Once approved, you will be able to log in and access the data within the DARM portal.
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 03/02/2026
Using brain samples from participants with #Alz, researchers generated small RNA data from over 250 people. Check out this dataset and more at DSS NIAGADS dss.niagads.org/datasets/ng...
dss.niagads.org
NG00167 - Brain Small RNA Transcriptomics for AD and Related Dementias - DSS NIAGADS
To access this data, please log into DSS and submit an application.Within the application, add this dataset (accession NG00167) in the “Choose a Dataset” section.Once approved, you will be able to log in and access the data within the DARM portal.
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 27/01/2026
NEW DATASET! Researchers used SomaScan and Metabalon to measure metabolite and protein levels in 3,000 participants of Caucasian and African ancestries. dss.niagads.org/datasets/ng...
dss.niagads.org
NG00180 - Four large scale pQTL and mQTL atlases in plasma from European and African ancestral groups - DSS NIAGADS
All data provided in this dataset are open access and are available publicly in the “Open Access Dataset” tab.
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Marios Georgakis @mariosgeorgakis.bsky.social · 23/11/2025
In our new preprint, we present the largest genomic exploration of arterial aging to date, leveraging photoplethysmography (PPG)–derived pulse waveforms from 115,000 UK Biobank participants. Our results provide insights into potential strategies to mitigate arterial aging👇
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Jonathan Pritchard @jkpritch.bsky.social · 11/12/2025
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday: www.nature.com/articles/s41... A short🧵:
nature.com
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
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Stephen Burgess @stevesphd.bsky.social · 16/12/2025
New paper: "Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data" out at BMC Medicine: link.springer.com/article/10.1.... Lots of interesting findings! Brief thread:
link.springer.com
Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data - BMC Medicine
Background Alcohol consumption has been linked to cancer risk. Evidence is strongest for seven cancer types: breast, colorectum, oesophagus, liver, mouth, pharynx, and larynx. However, evidence suppor...
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 20/01/2026
Keeping up with football season? New dataset explores the somatic changes in DNA in people with CTE by performing a GWAS of single neurons from the Prefrontal Cortex #genomics #neurology dss.niagads.org/datasets/ng...
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 13/01/2026
New #GWAS includes meta-analysis of eleven neuropathology endophenotypes from neuritic plaques and tau neurofibrillary to cerebral atherosclerosis and hippocampal sclerosis #genetics #data dss.niagads.org/datasets/ng...
dss.niagads.org
NG00175-Genome-wide association study of neuropathology endophenotypes - Shade et al. 2024 - DSS NIAGADS
To access the full dataset, please log into DSS and submit an application.Within the application, add this dataset (accession NG00175) in the “Choose a Dataset” section.Once approved, you will be able to log in and access the data within the DARM por
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 06/01/2026
Exploring genetic variations related to Alzheimer's in Koreans and Japanese people carrying the APOE ε4 gene. Check out this dataset and others in DSS #genetics #asianresearchers dss.niagads.org/datasets/ng...
dss.niagads.org
NG00182 – GARD GWAS Summary Statistics – Kang et al., 2024 - DSS NIAGADS
All data provided in this dataset are open access and are available publicly in the “Open Access Dataset” tab.
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 27/11/2025
It has been so good learning about new things
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 24/11/2025
HELP SHAPE THE FUTURE OF THE NIAGADS ALZHEIMER’S GENOMICSDB We're redesigning the GenomicsDB interface to make it faster and more useful for research We made a short survey focused on how users want to search, view, explore, and interpret genomic data #genomics #Alz
upenn.co1.qualtrics.com
Qualtrics Survey | Qualtrics Experience Management
The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 22/11/2025
New dataset contains GWAS summary statistics derived from single-variant association tests for WGS data from 3,540 Koreans aged 60 years or older #genomics #Alz
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 22/11/2025
New dataset contains GWAS summary statistics derived from single-variant association tests for WGS data from 3,540 Koreans aged 60 years or older #genomics #Alz
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 22/11/2025
New dataset contains GWAS summary statistics derived from single-variant association tests for WGS data from 3,540 Koreans aged 60 years or older #genomics #Alz
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 28/10/2025
Over the last year, we added almost 30k samples to our repository and now have over 140 datasets. This is Naveensri Saravanan giving our 2025 update. Thank you for visiting us at #ASHG2025!
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 28/10/2025
Hi-C and Capture Hi-C experiments create massive amounts of raw data that's hard to navigate. In this poster from #ASHG2025. Pavel Kuksa introduces CHARMER, a unified pipeline for mapping and harmonizing data. #genomics #gwas
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EMBL-EBI @ebi.embl.org · 07/03/2025
Discover more about FEGA’s journey and the future plans for the resource in the recent FEGA landmark paper published in Nature Genetics 👇 www.nature.com/articles/s41...
nature.com
The Federated European Genome–Phenome Archive as a global network for sharing human genomics data - Nature Genetics
In this era of rapidly expanding human genomics in research and healthcare, efficient data reuse is essential to maximize benefits for society. In response, the Federated European Genome–Phenome Archi...
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Mike Inouye @mikeinouye.bsky.social · 13/02/2025
📣📣Genomic data sharing: you don’t know what you’ve got (till it’s gone) www.nature.com/articles/s41... A comment @natrevgenet.bsky.social from @katholt.bsky.social and me
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NIAGADS - National Alzheimer's Database @niagads.bsky.social · 18/10/2025
Jeffrey Cifello presenting a poster yesterday titled "A fine-mapped multiomic human brain xQTL atlas and online portal leveraging four cohorts and six molecular phenotypes from the Alzheimer’s Disease Sequencing Project" #ASHG25
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