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Nick Chiappini 🏳️‍🌈🧪

@ndchiappini.bsky.social
2K followers 1.3K following 694 posts

Lover of weird rxns, reactive intermediates, hockey (mostly 🐧and🐙)and equitable sci. Asst Prof at UNCW. Queer AF. Ligand appreciator. Bird and space nerd. ChemSky. He/him

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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 21/08/2026
Time to channel Jay Kochi* *setting up an iron-catalyzed cross-coupling
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 15/08/2026
"people hate the new logo! I bet condescending to them will fix things!" Incredible work
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 31/07/2026
I'd mind the fundraising text pleas way less if they weren't all five paragraph essays of guilt-tripping and hyperbole. Give me a tight two sentence sell. Isn't this what you pay all that money to consultants for?
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 16/07/2026
YOOOO!!!! That fucking rules!!! congrats!!!
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 07/06/2026
Drag queen called Mrs. Kasha S. Rule - "There's ALWAYS time for an absorption"
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 07/06/2026
Drag queen called Molly B. Denim whose catchphrase is "You're telling me this nitrogen is ace?"
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 05/06/2026
This housane is a homeane
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Scott Bagley @bagphos.bsky.social · 04/06/2026
2+2 =4 cyclobutane Really nice work from Kevin Brown and Co at Indiana out in @angewandtechemie.bsky.social Densely functionalized cyBu with handles for additional derivatives - good dr as well. Nice job by all #ChemSky
onlinelibrary.wiley.com
Reenvisioning the De Mayo Reaction: A Boron‐Enabled Cycloaddition Approach
An oxa-boracycle conformational lock strategy enables photocatalytic [2+2] cycloaddition to afford densely substituted cyclobutylboronates. The conformational constraint suppresses triplet relaxation...
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 24/05/2026
Yumm. A smoken salmon crêpe is absolutely what I needed today
A delicious looking crepe with smoked salmon, creme fresh with dill, capers, and sliced egg
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Scott Bagley @bagphos.bsky.social · 19/05/2026
So we all know acid can remove a BOC… What if you have acid labile groups? Check out this #PfizerChemistry #JOCasap using HFIP and low eq acid to remove PGs - shorter rxn times and cleaner profiles Oh you’ve got a PMB? Check! CBZ too! No hydrog needed #ChemSky
pubs.acs.org
Sulfonic Acid Promoted N-Boc-, N-Cbz-, and N-PMB Cleavage in 1,1,1,3,3,3-Hexafluoro-2-Propanol (HFIP) and Application to Acid Sensitive Substrates
We report on the mild, sulfonic acid promoted removal of N-Boc, N-Cbz, and N-PMB protecting groups in 1,1,1,3,3,3-hexafluoro-2-propanol (hexafluoroisopropanol; HFIP). According to this method, the typ...
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 16/05/2026
Pool season is here!!!
Nick shirtless relaxing on a sun chair next to a pool. He is extremely pale, but pay no mind to that
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 07/05/2026
Rule of cool
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Puff the Magic Hater @mskellymhayes.bsky.social · 24/04/2026
I interviewed @chanda.blacksky.app about her new book, The Edge of Space-Time. We discussed cosmic wonder, the mythology of genius, Deep Space Nine, and thinking beyond false narratives and manufactured inevitabilities. If your brain is stuck in the churn of bad news, you'll want to check this out.
organizingmythoughts.org
“We Don’t Know Most Things”: Chanda Prescod-Weinstein on Curiosity and the Cosmos
"We have to be curious and imaginative about how we might get out of this," says Chanda Prescod-Weinstein.
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Michelle Brann @michellebrann.bsky.social · 13/04/2026
I’m thrilled to share that I’ll be joining Bryn Mawr College as a tenure-track Assistant Professor of Chemistry in January 2027! I’m excited to teach Bryn Mawr students, build the Brann Astrochemistry Group, and continue mentoring and empowering women and gender-diverse students in STEM. 🚀🌟
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 10/04/2026
Was extremely happy to come home to this today! I've got my weekend reading locked in 😎 @chanda.blacksky.app
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Lisa Jarvis @lisamjarvis.bsky.social · 07/04/2026
The moon was still out when I awoke today & I stood in my living room grinning at it for awhile-I mean, can you believe that yesterday, the Artemis crew was RIGHT THERE? My latest @opinion.bloomberg.com is on the awe-inspiring mission as a crucial reminder of the value of investing in science. (🎁)
bloomberg.com
Artemis II’s Awe Reminds Us of Science’s Fragility and Importance
Three words uttered yesterday from Mission Control to Reid Wiseman, commander of Artemis II, perfectly capture the groundswell of emotion many of us have experienced over the last week as a team of as...
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 06/04/2026
The fact that all software switched to subscription rather than license model is a fucking crime. "Sign into revitty signals to use your ChemDraw." What if, and I know this is crazy, you just STICK TO THE ACTIVATION SYSTEM YOU'VE HAD SINCE THE BEGINNING. Seething rn.
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 02/04/2026
Request: PAA stain that doesn't go to complete dogshit in like a week on the bench even when protected from light
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 29/03/2026
Where are my fellow jazz band kids at? Is it just me or does Bruno Mars new song sound like Oye Como Va?
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Scott Bagley @bagphos.bsky.social · 25/03/2026
Today at #ACSSpring2026 we’ve got @ndchiappini.bsky.social in Academia 101 : Launching Your Lab talking about how to apply and interview for a faculty position and get ready to teach - stop by and hear from all our young faculty
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 24/03/2026
@chemfunman.bsky.social encounter!!! Love ACS!
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Adam Gurri @adamgurri.liberalcurrents.com · 09/02/2026
So uh Ring just up and said they've got a huge centralized private surveillance network they can leverage all at once huh
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Silicon Republic @siliconrepublic.bsky.social · 03/02/2026
Mozilla will allow Firefox users to entirely block current and future generative AI features on the browser after user feedback revealed many who wanted an AI-free browser experience.
siliconrepublic.com
New Mozilla Firefox version to allow AI features to be blocked
Mozilla will allow Firefox users to entirely block current and future generative AI features on the browser.
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 06/02/2026
HTE setups realizing they're being used for a Buchwald-Hartwig screen for the 1,286,712th time
A deeply haggard, starved and desperate Sarah Paulson faking a smile while eating a wholly underwhelming sandwich provided by her captor.  She is saying "This is good"
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 05/02/2026
It's honestly impressive how infuriating to use OneLan digital signage is. Forget user-friendliness, this is user antagonism
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 31/01/2026
A peek at my non-chemistry picks! Sociology of Science Fiction Deconstructing the Darkness of German Fairytales American Art History Modernism in Art and Music Italian Political History from Unification to Present
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Chanda Prescod-Weinstein 🌌 @chanda.blacksky.app · 30/01/2026
Please buy books that are coming out this year. Doesn’t have to be mine. But there is a stellar release calendar this year especially of Black writers and it would be a shame if one of the fascist victories was people not buying those books (from the indies that are in the fight with us). #BookSky
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Hockey Out of Context Loves Canada @nhloutofcontext.bsky.social · 21/01/2026
Andrei Vasilevskiy
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 29/01/2026
Awesome!!!! That's great to hear. Thank you so much!!!
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Woah! 8 hrs is crazy! What works works though!!
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Thank you!!! This is great.
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
@chemrxiv.org Is there an RSS feed for the new host? I can't seem to find one via Feedly or the new site. (sorry for the double post, wasn't sure which platform was checked more often)
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Love when the science looks like a glitch in the matrix!
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Similarly, I love showing my students how to liquid load with it and showing them how you can check your packing/band thickness by watching the little translucent band spread as you push it through your Hx/EA column.
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
We used it once for a chromatography of spinach pigments demo for the orgo labs when I was an undergrad! Definitely leaves an impact seeing basically "floating" red, orange, green, and blue bands!
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
I have a single 4L of CHCl3, basically only really use it for liquid loading annoying compounds for columns or chasing off last bits of other solvents before a final high vac excursion.
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
At least with the EtOH stabilized stuff you can wash with water and then dry/distill. The amylenes on the other hand linger like the glitter after a birthday party for a 6 year old.
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
I def see much more CCl4 in modern stuff from 🇷🇺 than I do EU, US, CAN, JPN, or even CN! Read one paper from I think last year that was azeotropically drying with it. Completely alien to me since it's been so regulated my entire life lol.
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
@barneygrubbs.bsky.social raised that it is probably a recycling GPC! So probably doesn't use that much all said!
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Today I Learned!
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Plus, when we talk about black-body radiation, we get to talk about the ultraviolet catastrophe, which I'm adamant should be a band name if it isn't already. Share your frustration, Chanda!! Ugh
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Reposted by Nick Chiappini 🏳️‍🌈🧪
Chanda Prescod-Weinstein 🌌 @chanda.blacksky.app · 28/01/2026
Black-body radiation is something we’ve understood for over a century, I teach it in my undergrad astrophysics classes, and it’s how the quantum revolution kicked off en.wikipedia.org/wiki/Black-b...
en.wikipedia.org
Black-body radiation - Wikipedia
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Prep HPLC I've done once! Prep GPC sounds wild. I always am a bit agog when I read like JACS from the 50s-60s where they do prep GC (often annotated as VPC/GLC). Never seen one in action but I picture like a little nozzle just spritzing into a collection bottle lol.
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
I have seen it one other time....also for like a C-H borylation/silylation system. I do wonder if it's specifically because the pdts are so friggin non-polar and have big volume due to the Bpin/etc.... regardless it def has me scratching my head
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
"Gel-permeation chromatography (GPC) was performed on SHIMADZU LC-20A equipped with FP-2002 columns." Guessing they must have it rigged up to a fraction collector or something which threw me
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Right! That's my usual inkling when I think GPC, but so far as I can tell after some more digging, the paper I'm looking at is using a polystyrene/DVB column on a Shimadzu and def purifying small molecules. ex. "compound xx was purified via GPC using CHCl3 as solvent"
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Hmmm. I guess they must just hook up a GPC column to a standard pump/detector rig and fraction collector.... Always cool/unsettling when you come across a new preparative purification technique you feel like you should have had a handle on
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Like....it's gotta be on an instrument right? Not a manual technique
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Nick Chiappini 🏳️‍🌈🧪 @ndchiappini.bsky.social · 28/01/2026
Potentially ignorant question: When a small molecule synthesis paper mentions using "GPC" for purification....what does that mean operationally? GPC immediately is like neon sign for POLYMERS and ANALYTICAL in my head. #chemsky
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