Reposted by Ignacio Perez
🧬 HIV reaches the nucleus. But where it goes in the presence of LENACAPAVIR Gilead Sciences next matters.
In Science Advances, we show that lenacapavir doesn't stop HIV at the nuclear door—it changes its destination.
www.science.org/doi/10.1126/...
science.org
Capsid stabilization reprograms the nuclear fate of the HIV genome
Ultrastructural analysis reveals that LEN stabilizes capsids in nuclei, reprogramming HIV-1 trafficking to PML-NBs.
