iiinova — where your digital self keeps evolving

Reposted by Mykhaylo M. Malakhov

Dariia Mykhailyshyna @dariia.bsky.social · 19/09/2026

Looking for more speakers for Workshops for Ukraine (sites.google.com/view/dariia-...), so if you want to contribute to a series by teaching a workshop on #Rstats, #Python, data analysis, while helping raise money for Ukrainian charities, drop me a message or email dmykhailyshyna@kse.org.ua #Econsky

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Reposted by Mykhaylo M. Malakhov

Joshua G. Schraiber @jgschraiber.bsky.social · 08/09/2026

This is fucking insane. It's unclear what the future of mathematics looks like at this point. It's hard to express how big of an advance this is. Yes, there are serious issues about credit here, but all parties agree: this proof was enabled and perhaps principally shaped by AI.

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Mykhaylo M. Malakhov @mykmal.xyz · 04/09/2026

I'm no prophet, but I did write a 15-page essay in high school arguing that tech companies should embrace open source because the biggest revenue streams in the future will be services and compute, not code.

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Reposted by Mykhaylo M. Malakhov

Josh Weinstock @joshweinstock.bsky.social · 25/08/2026

Excited to share our latest foray into studying the ways in which germline variation gives rise to somatic variation in aging blood: www.medrxiv.org/content/10.6... In work led by @prarthana-s-r.bsky.social , we map how common and rare germline variation links to (somatic) passenger mutations 🧬🧵👇

medrxiv.org

Multi-ancestry analysis of 791K whole genomes reveals the genetic, geographic, and phenotypic correlates of somatic passenger mutations in blood

Clonal hematopoiesis (CH), an aging-related expansion of hematopoietic stem cell (HSC) clones, is associated with hematologic malignancy, cardiovascular disease, and mortality. Most clonal expansions,...

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Mykhaylo M. Malakhov @mykmal.xyz · 18/08/2026

This is all I have to show for my data harmonization efforts, sorry.

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Mykhaylo M. Malakhov @mykmal.xyz · 13/08/2026

People who completed their education right when capable LLMs were becoming available will be the biggest beneficiaries of AI-driven productivity gains. Everyone before them had to build their careers without the help of AI, while those after them are missing out on the rigor of pre-AI learning.

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Mykhaylo M. Malakhov @mykmal.xyz · 15/07/2026

This is very cool work! Most research in statistical genetics does not take evolutionary theory into account, but Hanbin's paper shows how doing so can explain the success of empirically-derived models and make them even more effective.

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Mykhaylo M. Malakhov @mykmal.xyz · 02/06/2026

"mtDNA copy number and expression are largely decoupled, and above a certain rate-limiting threshold, mtDNA accessibility — rather than absolute copy number — is the more relevant quantity for explaining inter-individual differences in gene expression."

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Mykhaylo M. Malakhov @mykmal.xyz · 29/05/2026

IGES is my favorite scientific conference. It has a small, intimate feel and remains focused on genetic epidemiology and statistical genetics, which makes networking easy and puts your research in front of an enthusiastic audience. I'm going again and hope to see many of you there!

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Mykhaylo M. Malakhov @mykmal.xyz · 06/05/2026

After closely following generative AI research for the past several years but intentionally not using AI in my own work, I finally decided to bite the bullet. So far, it is both more useful and less useful than I expected.

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Mykhaylo M. Malakhov @mykmal.xyz · 04/04/2026

"What matters is the process: the development and application of methods, the training of minds, the creation of people who know how to think about hard problems. If you hand that process to a machine, you haven't accelerated science. You've removed the only part of it that anyone actually needed."

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Mykhaylo M. Malakhov @mykmal.xyz · 25/03/2026

It's so exciting to see the company where I interned as a PhD student obtain their first FDA approval! This is huge news for the Hunter Syndrome community and a major milestone in the development of biotherapeutics that cross the blood-brain barrier. investors.denalitherapeutics.com/news-release...

investors.denalitherapeutics.com

Denali Therapeutics Announces U.S. FDA Approval of AVLAYAH™ (tividenofusp alfa-eknm) for Treatment of Hunter Syndrome (MPS II) | Denali Therapeutics

The Investor Relations website contains information about Denali Therapeutics's business for stockholders, potential investors, and financial analysts.

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Mykhaylo M. Malakhov @mykmal.xyz · 18/03/2026

I'm proud to see that my PI @lindakachuri.bsky.social has been elected to the @geneticepi.bsky.social Board of Directors! It's time to make IGES cool again 😎

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Mykhaylo M. Malakhov @mykmal.xyz · 23/01/2026

I wanted to keep this account focused on science, but it is hard to stay silent on political issues right now. My home country is still being bombed by Russia, the city I lived in for the past several years is under occupation by ICE, and the funding that supports my work is constantly threatened.

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Mykhaylo M. Malakhov @mykmal.xyz · 20/12/2025

My second dissertation paper is now out in @natcomms.nature.com! Here we introduce the co-expression-wide association study (COWAS) method for identifying pairs of genes or proteins whose genetically regulated co-expression is associated with complex traits. 🧵⬇️ www.nature.com/articles/s41...

nature.com

Co-expression-wide association studies link genetically regulated interactions with complex traits - Nature Communications

Proteins can affect traits through their interactions with one another. Here, the authors propose the COWAS method to identify pairs of interacting genes or proteins whose genetically regulated co-exp...

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Mykhaylo M. Malakhov @mykmal.xyz · 23/11/2025

"The aim of equity is not to brag about how many students of a target background you awarded an A in calculus, it’s to ensure that every student actually learns." This is such an important and timely article. I have noticed a lot of the same issues myself. www.theargumentmag.com/p/when-grade...

theargumentmag.com

When grades stop meaning anything

The UC San Diego math scandal is a warning

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Mykhaylo M. Malakhov @mykmal.xyz · 07/11/2025

This is an exceedingly late post, but I wanted to share a few pictures from #IGES2025 earlier this fall. I had the honor of giving a platform talk on age-related genetic dysregulation, and I really enjoyed connecting with other researchers and exploring the beautiful city of Cologne!

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Reposted by Mykhaylo M. Malakhov

International Genetic Epidemiology Society @geneticepi.bsky.social · 31/08/2025

We can't wait to see you in Cologne this week for #IGES2025!! See below for some important reminders 👇

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Mykhaylo M. Malakhov @mykmal.xyz · 10/08/2025

The use of dichotomized labels for traits that are actually continuous has bothered me ever since I started working on complex trait genetics. Sasha's blog post provides an excellent explanation of why this matters in the context of polygenic risk and embryo selection.

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Mykhaylo M. Malakhov @mykmal.xyz · 24/07/2025

Yesterday I successfully defended my dissertation! It feels surreal to finally reach the end of my PhD journey at @umnsph.bsky.social. Thank you to my adviser Wei Pan and to my committee members @elock.bsky.social, @aazaidi.bsky.social, and Thierry Chekouo for your invaluable mentorship and support!

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Mykhaylo M. Malakhov @mykmal.xyz · 28/05/2025

I had a great time at STATGEN 2025 last week! Thank you to everyone who came to my talk and to the organizers for putting on this conference.

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Reposted by Mykhaylo M. Malakhov

International Genetic Epidemiology Society @geneticepi.bsky.social · 19/05/2025

This year's IGES Annual Meeting and Education Workshop will be held Aug. 31 - Sept. 2 in the beautiful city of Cologne, Germany. Join us for an exciting lineup of keynote presentations, platform talks, posters, and hands-on tutorials at #IGES2025! Learn more: www.geneticepi.org/2025-annual-...

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Mykhaylo M. Malakhov @mykmal.xyz · 16/05/2025

Follow @geneticepi.bsky.social to stay up to date on news and events from IGES! This will be the society's primary social media presence going forward, and we will be sharing a lot of cool and useful content. Full disclosure: I manage the IGES account.

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Mykhaylo M. Malakhov @mykmal.xyz · 13/05/2025

A reviewer described my COWAS method as "a significant breakthrough in the study of gene-gene (protein-protein) interaction." Before that, the very same paper was desk rejected by four other journals. The moral of this story is obvious and left as an exercise to the reader.

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Mykhaylo M. Malakhov @mykmal.xyz · 07/05/2025

I'm excited to share our latest work, now out in #PLOSGenetics! If you feel limited by linear models in TWAS or PWAS but don't think you can switch to nonlinear methods due to a lack of individual-level phenotype data, this paper is for you. 🔗 journals.plos.org/plosgenetics... Thread below 👇 (1/6)

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