Sign in

Eric F. Lock

@elock.bsky.social
120 followers 189 following 4 posts

Biostatistician at University of Minnesota

PostsRepliesMedia
Reposted by Eric F. Lock
Joshua Weitz @joshuasweitz.bsky.social · 07/03/2026
The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302
18698420
Reposted by Eric F. Lock
Mykhaylo M. Malakhov @mykmal.xyz · 20/12/2025
My second dissertation paper is now out in @natcomms.nature.com! Here we introduce the co-expression-wide association study (COWAS) method for identifying pairs of genes or proteins whose genetically regulated co-expression is associated with complex traits. 🧵⬇️ www.nature.com/articles/s41...
nature.com
Co-expression-wide association studies link genetically regulated interactions with complex traits - Nature Communications
Proteins can affect traits through their interactions with one another. Here, the authors propose the COWAS method to identify pairs of interacting genes or proteins whose genetically regulated co-exp...
1145
Reposted by Eric F. Lock
Mitchell O'Hara-Wild @mitchelloharawild.com · 04/08/2025
There's so many parallel sessions at #JSM2025 that it's hard to choose where to go, so I web-scraped the schedule and made a chatbot to help. I've made it public, so hopefully it can help you too - try it out 👉 shiny.mitchelloharawild.com/jsm2025/
A screenshot of my JSM 2025 Agenda Chat bot, featuring the answer to "when is Mitchell O'Hara-Wild presenting".
4198
Reposted by Eric F. Lock
Mykhaylo M. Malakhov @mykmal.xyz · 24/07/2025
Yesterday I successfully defended my dissertation! It feels surreal to finally reach the end of my PhD journey at @umnsph.bsky.social. Thank you to my adviser Wei Pan and to my committee members @elock.bsky.social, @aazaidi.bsky.social, and Thierry Chekouo for your invaluable mentorship and support!
041
Reposted by Eric F. Lock
Seth D. Temple @sdtemple.bsky.social · 19/05/2025
I'm excited to present my work on rigorous and scalable multiple-testing corrections for complex haplotype scans in WGS at ASA STATGEN 2025! t.co/rv205OBCs1
011
Reposted by Eric F. Lock
Kasper D Hansen @kasperdhansen.bsky.social · 21/05/2025
I am at StatGen 2025 in Minneapolis. I would be happy to chat with students or postdocs about research or career questions. Send me a DM.
001
Reposted by Eric F. Lock
Mykhaylo M. Malakhov @mykmal.xyz · 07/05/2025
I'm excited to share our latest work, now out in #PLOSGenetics! If you feel limited by linear models in TWAS or PWAS but don't think you can switch to nonlinear methods due to a lack of individual-level phenotype data, this paper is for you. 🔗 journals.plos.org/plosgenetics... Thread below 👇 (1/6)
195
Reposted by Eric F. Lock
Joe Koopmeiners @jskoopmeiners.bsky.social · 24/04/2025
So proud of my colleague @jaredhuling.bsky.social for being named a McKnight Presidential Fellow! I'm thrilled to have him as a colleague and look forward to the great things he'll do in the future!
sph.umn.edu
School of Public Health Assistant Professor Jared Huling receives McKnight Presidential Fellow Award - School of Public Health - University of Minnesota
University of Minnesota (UMN) School of Public Health (SPH) Assistant Professor Jared Huling is a recipient of the prestigious McKnight Presidential
031
Reposted by Eric F. Lock
Joe Koopmeiners @jskoopmeiners.bsky.social · 08/04/2025
Excited to share new research from my former student Ales Kotalik, along with David Vock, Brian Hobbs, and Nancy Sherwood. Here we discuss how dynamic borrowing methods developed for precision oncology can also be used to improve efficiency in a SMART.
academic.oup.com
Within-trial data borrowing for sequential multiple assignment randomized trials
Summary. The Sequential Multiple Assignment Randomized Trial (SMART) is a complex trial design that involves randomizing a single participant multiple time
022
Reposted by Eric F. Lock
Jeremy Berg @jeremymberg.bsky.social · 29/03/2025
F mechanisms (New and Competitive renewals) Oof! 3/n
119554
Reposted by Eric F. Lock
ENAR @enar-ibs.bsky.social · 24/03/2025
Congratulations to Leif Verace from the University of Minnesota, the 2025 ENAR Van Ryzin Student Paper Award winner! ⭐️
041
Reposted by Eric F. Lock
Jeremy Berg @jeremymberg.bsky.social · 15/03/2025
NIH Reporter data through this morning (grants funded up to March 8th) First, new and competitive renewal grants... 2/n
35422
Reposted by Eric F. Lock
Amstat-American Statistical Association @amstatnews.bsky.social · 25/02/2025
Celebrating Black History Month: Initially drawn to combining math and finance, Sandra Safo's path shifted after she discovered data analysis during her studies. Sandra now develops innovative statistical and machine learning methods to advance health care research. magazine.amstat.org/...
A headshot of Sandra Safo with the tagline "Celebrating Black History Month"
052
Reposted by Eric F. Lock
Jeremy Koster @jeremykoster.bsky.social · 19/02/2025
Upon learning that yesterday would be my last day as a program officer at the National Science Foundation, I shared this parting message with my colleagues. The next few months will be frenetic and stressful for them. Here are some things that you can do to help them with the mission ahead. (1)
692415821
Reposted by Eric F. Lock
Carl T. Bergstrom @carlbergstrom.com · 08/02/2025
1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
25470014078
Eric F. Lock @elock.bsky.social · 31/01/2025
Interested in #statistics in #genomics and #genetics? Join us May 21-23 in Minneapolis for the 2nd annual STATGEN Conference for the ASA's Section on Statistics in Genomics and Genetics. Registration and abstract submission (deadline February 15th) are open to all. www.sph.umn.edu/events-calen...
sph.umn.edu
STATGEN 2025: Conference on Statistics in Genomics and Genetics - Events Calendar - School of Public Health - University of Minnesota
030
Reposted by Eric F. Lock
Science Magazine @science.org · 22/01/2025
“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO
scim.ag
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing
471019723
Eric F. Lock @elock.bsky.social · 18/12/2024
Introducing BAMITA: Bayesian Multiple Imputation for Tensor Arrays! Simulate realistic values for missing data in tensors. Applied to longitudinal microbiome data. With PhD student extraordinaire Ziren Jiang, & Gen Li from the "other" U of M. In Biostatistics and on arXiv. doi.org/10.1093/bios...
academic.oup.com
BAMITA: Bayesian multiple imputation for tensor arrays
Abstract. Data increasingly take the form of a multi-way array, or tensor, in several biomedical domains. Such tensors are often incompletely observed. For
060
Eric F. Lock @elock.bsky.social · 19/11/2024
Introducing EV-BIDIFAC - decompose low-rank signal across linked matrices efficiently with a model-based framework & no tuning parameters! Reviewer 2 *raves* "my primary concerns have been addressed with this revision". Available now at Machine Learning and arXiv! link.springer.com/article/10.1...
link.springer.com
Empirical Bayes linked matrix decomposition - Machine Learning
Data for several applications in diverse fields can be represented as multiple matrices that are linked across rows or columns. This is particularly common in molecular biomedical research, in which m...
160
Reposted by Eric F. Lock
Julian Wolfson @drjwolfson.bsky.social · 17/11/2024
Trying again with a working link: We’ve just posted a new Contract Assistant Professor position at UMN Biostat & Health Data Science! Happy to discuss with anyone interested. #biostatistics #healthdatascience #academicjobs hr.myu.umn.edu/jobs/ext/365...
hr.myu.umn.edu
Careers
Required qualifications:Applicants must have a PhD in biostatistics, statistics, or a closely related field, by the start of appointment and a strong interest in collaborative research with biomedical investigators across the health sciences.
097