Ouellette et al. report that a 16p11.2 deletion induces a bioenergetic failure in brain endothelial cells. Activation of purinergic signaling via P2Y2 receptors restored endothelial function and impro...

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The hypothalamus is a central regulator of glucose and energy homeostasis, with arcuate nucleus (ARC) neurons orchestrating these processes. Agouti-related peptide (AgRP) and pro-opiomelanocortin (POM...

Fear learning increases the similarity of threatening and neutral context representations in ventral CA1, which may enable faster reinstatement of threat memories, compared to dorsal CA1.

Growing evidence shows that dopamine signaling is diverse, with dopaminergic neurons responding to rewarding and aversive stimuli. Here, we hypothesiz…

Neurons have long taken top billing in memory, but researchers are making the case for astrocytes.

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...

In this issue of Neuron, Ghenissa and colleagues1 show that intracellular Ca2+ signaling within populations of astrocytes in the basolateral amygdala of mice encodes anxiety states that are regulated ...

The Fraser Lab at the University of Minnesota (https://fraserlab.psych.umn.edu/) is recruiting a full-time research technician to support the lab. As a part of the Department of Psychology we are involved in the greater neuroscience research community at the University of Minnesota which provides excellent access to training and professional development. The Fraser Lab is interested in the neurobiological basis of motivated behavior and investigates how defined brain circuits contribute to behavioral regulation. We make use of modern neuroscience approaches to record and manipulate neural activity in real-time as rodents perform complex behavioral tasks to relate precise aspects of neural activity to well-defined psychological processes. To do so, we regularly use optogenetics, chemogenetics, calcium imaging, biosensors, pharmacology, and immunohistochemistry. Our ultimate goal is to decipher the neural mechanisms regulating behavior and to characterize how these are altered in psychiatric illness, such as addiction, or by differences in lived experience, such as after early life adversity, to potentially identify novel therapeutics. We seek a team member who can play a lead role in lab operations, collaborate closely with the PI, and engage in team-building and growth.Duties:Laboratory logistics, maintenance and operations (30%):

La plus grande banque de cerveaux au Canada permet des études sur l’alzheimer, le parkinson, mais aussi le suicide et la dépression majeure.

The Williamson Lab studies astrocyte biology across development, cognition, and disease.