Ueno et al. show that the phosphorylation of CLK1 functions as a molecular switch controlling its temperature-dependent localization to nuclear stress bodies. This regulation is mediated by a multilayered thermosensing mechanism involving PPP1R2, an intrinsically disordered thermosensor regulating PP1-mediated dephosphorylation during stress, and RIOK2-dependent rephosphorylation during recovery, coordinating temperature-dependent pre-mRNA splicing.

This review outlines how mammalian cells adapt to cold via ion channels, uncoupling proteins, epigenetic changes, and RNA-binding proteins, with insights from hibernators highlighting therapeutic pote...

A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketoge...

Using xenograft inflammation–recovery models and single-cell multiomics, a haematopoietic stem cell population after inflammatory stress is identified.

Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthe...

The authors develop a system to erase DNA methylation at H19-DMR in mouse sperm. Despite loss, methylation partly recovers via H3K9me3 after fertilization, revealing partial intergenerational epigenet...

Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al. show that TCA cycle rewiring underlies mouse embryo implantation and the exit from naive pluripotency. In this context...

Abstract. Embryonic genome activation (EGA) marks a critical developmental transition, yet its regulatory architecture remains incompletely defined. Here,

The intracellular delivery of trans-cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron-demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro)...

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Nature Communications - Gestational exposure of mice to the obesogen tributyltin alters 3-D chromatin interactions in primordial germ cells leading to stable reduction of hepatic Ide expression and...

Oncogene - CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer

Jorgensen, Bao, Junyent, et al. aggregate ESCs, TSCs, and PE-fated inducible GATA4-ESCs to build iGATA4-blastoids: robust and highly efficient stem cell models of the mouse blastocyst. iGATA4-blastoid...

A histone ubiquitin-dependent regulatory hub governs stimulus-dependent heterochromatin propagation, with important implications for understanding mechanisms governing rapid changes in the epigen...

Hematopoietic stem cells (HSCs) give rise to nearly all blood cell types and play a central role in blood cell production in adulthood. For many years it was assumed that these roles were similarly re...

The aorta-gonad-mesonephros (AGM) is a region of embryonic mesoderm that develops during embryonic development from the para-aortic splanchnopleura in chick, mouse, and human embryos. The AGM contain....

Chovatiya et al. developed PReCIS-seq, an in vivo approach that maps transcriptionally engaged RNA polymerase II in Cre-targeted cells within intact mouse tissues, without cell isolation. They report ...

The authors identify a chemical cocktail to generate totipotent-like cells, which they then use to build an embryo model. This model captures a developmental spectrum from early embryogenesis to post-...

Here the authors identify RNA G-quadruplexes as temperature-sensitive regulators of alternative splicing and gene expression, opening potential therapeutic avenues such as neuroprotection with potassi...

Not all cells that can be infected by a virus become infected with that virus. Single-cell clone tracing reveals intrinsic cell states with variable expression patterns that increase susceptibility to...

Cells store information by means of chromatin modifications that persist through cell divisions and can hold gene expression silenced over generations…

scFLUENT-seq is a single-cell method that sensitively captures nascent nuclear transcriptomes to reveal mRNA and ncRNA dynamics, heterogeneity across chromatin compartments, and transcriptional divers...

Acquisition of specific cell shapes and morphologies is a central component of cell fate transitions. Although signaling circuits and gene regulatory networks that regulate pluripotent stem cell diffe...

Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...

Kawamura et al. show that H3K36me2 removal by the KDM2A and KDM2B histone demethylases restricts DNMT3A in establishing global DNA methylation in oocytes. Maternal Kdm2a/Kdm2b knockout embryos die dur...

Cells and organisms can enter transient dormant states to survive unfavorable conditions during development, physiological adult contexts, and disease. One paradigmatic case of dormancy is diapause, w...

Elections and nominations for the International Society for Stem Cell Research board of directors and officers.

The MYC transcription factor is a key regulator of growth during development and a potent cancer driver when its expression is dysregulated. Strategies to inhibit MYC oncogenic activity would mark a s...

Here they identify Tex10 as a critical regulator of male fertility and germ cell development. By fine-tuning Wnt signaling, Tex10 promotes spermatogenesis and PGC differentiation, offering potential t...

Single-cell transcriptome profiling of mouse embryos and newborn pups is combined with previously published data to construct a tree of cell-type relationships tracing development from zygote to birth...