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Modernising Medical Microbiology

@modmedmicro.bsky.social
164 followers 45 following 55 posts

Modernising Medical Microbiology is a research unit within @ox.ac.uk aiming to transform how we analyse and treat infections, to improve patient care.

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Sam Lipworth @samlipworth.bsky.social · 30/09/2026
Great new work from @dotnagy.bsky.social who has developed EpiSENTRY which performs sample size calculations for public health WGS surviellance studies. She applies to data from the NEKSUS study to estimate how much sequencing is enough for GNBSI surviellance in England. @modmedmicro.bsky.social
medrxiv.org
How much is enough? Optimising sampling frames for genomic surveillance of Escherichia coli and Klebsiella spp. bloodstream infections - a retrospective study
Background: Optimising sampling frames for genomic surveillance of E. coli and Klebsiella may support interventions to mitigate bloodstream infections (BSIs), but approaches to estimating sample size ...
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Bash the bug @bashthebug.net · 29/09/2026
Infusoria BioArt exhibition exploring microbiology opens at the John Radcliffe Hospital! 📅 26 September – 6 November 2026 📍 Artlink Corridor Gallery, John Radcliffe Hospital, Oxford #ArtAndScience #Microbiology #AntimicrobialResistance #InfectionPrevention #PublicEngagement
bashthebug.net
Infusoria BioArt exhibition exploring microbiology opens at the John Radcliffe Hospital
BioArt exhibition exploring microbiology opens at the John Radcliffe Hospital A new display of work by artist Anna Dumitriu is now on show at the John Radcliffe Hospital, bringing together art, microbiology and research into healthcare-associated infections. The exhibition draws on research from Modernising Medical Microbiology into hospital environments, bacteria and antimicrobial resistance. Through BioArt, Anna’s work explores the microbial world that usually remains unseen and encourages people to think differently about the relationship between microorganisms, healthcare and our surroundings.
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Bash the bug @bashthebug.net · 23/09/2026
Beyond the basin: my research internship at Oxford Hospital sinks are essential for handwashing, but beneath the basin lies a complex microbial environment that may present challenges for infection prevention... Read more on our blog! #AMR #InfectionPrevention
bashthebug.net
Beyond the basin: my research internship at Oxford
Hospital sinks are essential for handwashing, but beneath the basin lies a complex microbial environment that may present challenges for infection prevention. During my internship at the University of Oxford, I had the opportunity to contribute to research investigating the microorganisms found in hospital sinks and their potential relevance to patient safety. I worked under the supervision of Dr Aoife Kearney on the SELECTION project, building on Professor Nicole Stoesser and her colleagues’ research into hospital sink environments and healthcare-associated infections.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 23/09/2026
Please share with anyone who might be interested! Supervisors: Prof. @nstoesser.bsky.social, Dr. @kevin-chau.bsky.social, Dr. Aoife Kearney #Microbiology #PhDOpportunity
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Modernising Medical Microbiology @modmedmicro.bsky.social · 23/09/2026
A great opportunity for someone interested in #metagenomics, microbial genomics, #bioinformatics, AMR and infectious disease epidemiology! The deadline for applications to be considered for internal funding for entry in 2027 is Tuesday 1st December 2026.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 23/09/2026
The project will explore how metagenomic sequencing of composite samples from patients and healthcare environments can be used to improve surveillance of pathogen and #AMR transmission.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 23/09/2026
DPhil opportunity at the University of Oxford 🦠 We’re looking for a motivated DPhil student to join us to develop innovative metagenomic approaches for surveillance of healthcare-associated pathogens and antimicrobial resistance (AMR). Find out more and apply here!
ndm.ox.ac.uk
DPhil project themes
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Philip Bejon @philipbejon.bsky.social · 11/09/2026
New publication from @modmedmicro.bsky.social on metagnomic RNA virus detection from upper respiratory samples - www.sciencedirect.com/science/arti... @nickdsandy.bsky.social @treestreet.bsky.social @dotnagy.bsky.social @samlipworth.bsky.social @oxfordbrc.bsky.social
sciencedirect.com
Clinical validation of an optimised metagenomic nanopore sequencing method for detecting viral respiratory pathogens
Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Seque…
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Reposted by Modernising Medical Microbiology
Bash the bug @bashthebug.net · 03/09/2026
Microbiology is coming out of the lab! Infusoria, a new exhibition by MMM Artist-in-Residence Anna Dumitriu, runs in the JR Hospital from 26 Sept–6 Nov 2026. New works inspired by Oxford research explore hospital sinks, wastewater, water microbiomes and antimicrobial resistance.
bashthebug.net
When microbiology becomes art: Infusoria
Infusoria 26 September – 6 November 2026Artlink Corridor Gallery, John Radcliffe Hospital, Oxford From hospital sinks to BioArt: our microbiology research inspires new exhibition Infusoria What does the microbial world of a hospital sink look like when viewed not only through the lens of microbiology, but through art? Research from Modernising Medical Microbiology (MMM) at the University of Oxford…
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Modernising Medical Microbiology @modmedmicro.bsky.social · 26/08/2026
A productive visit and an exciting step towards connecting microplastic analysis in hospital environments with #AMR research.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 26/08/2026
These analyses will help us better understand the microplastic profiles within hospital sink environments and support our next steps in investigating their potential role in harbouring antimicrobial-resistant (AMR) bacteria.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 26/08/2026
The visit provided a valuable opportunity to gain insight into the analytical workflow, discuss preliminary results, and exchange expertise on the characterisation of microplastics present in these samples.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 26/08/2026
A closer look at microplastics! Recently, we visited @ukceh.bsky.social to explore the analysis of #microplastics in sink trap aspirates collected from hospital environments. @afswinkels.bsky.social
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Cat Baker @catcsb10.bsky.social · 25/08/2026
Happy to share my first paper! We developed an optimised #ONT workflow for sequencing mycobacteria directly from positive MGIT cultures, achieving 98.3% agreement with Illumina for species identification, with reliable results often within 6 hours. #PathogenGenomics #TB @modmedmicro.bsky.social
journals.asm.org
Validation of an optimized Oxford Nanopore sequencing workflow versus Illumina for mycobacteria from primary MGIT culture | Microbiology Spectrum
Rapid genomic characterization of mycobacterial infections is important for timely patient management, infection control, and public health surveillance. However, many diagnostic laboratories rely on ...
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Bash the bug @bashthebug.net · 03/08/2026
Read our new blog post! Risk factors for antimicrobial resistance in cancer patients and survivors: an electronic health record study by Annie Hu
bashthebug.net
Risk factors for antimicrobial resistance in cancer patients and survivors: an electronic health record study
Bloodstream infections occur when bacteria (which are germs that can cause disease) enter the blood and grow there. These infections are usually treated with antibiotics. However, bacteria can become resistant, meaning the antibiotics no longer work, and this is called antimicrobial resistance (AMR). It is a major worldwide health problem and people with cancer are especially at risk because both cancer treatments and the cancer itself weaken their immune systems (bodies own protection system).
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Bash the bug @bashthebug.net · 01/06/2026
NIHR webinar on BashTheBug on YouTube BashTheBug was originally a large international citizen science project that invited anyone to help us classify how well different samples of M. tuberculosis grew in the presence of a range of antibiotics. It ran from 2017 to 2021 and in that time 46,427…
bashthebug.net
NIHR webinar on BashTheBug on YouTube
BashTheBug was originally a large international citizen science project that invited anyone to help us classify how well different samples of M. tuberculosis grew in the presence of a range of antibiotics. It ran from 2017 to 2021 and in that time 46,427 people took part and collectively they classified 4,746,420 images of M. tuberculosis growing on different concentrations of one of 13 antibiotics. 
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Bash the bug @bashthebug.net · 28/05/2026
Thanks to the team for all their hardwork preparing and delivering the activities, especially in this heatwave! 🌞🌞🌞
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Bash the bug @bashthebug.net · 28/05/2026
And our DNA detective programme was a smash🕵‍♀️ Follow the bioinformatic instructions to figure out which patient in a ward has which infection, and work out from the hints which drugs will help the patient get better!
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Bash the bug @bashthebug.net · 28/05/2026
The Mystery Outbreak poster was a hit! A cluedo-esque mystery where you had to follow the clues to find the source of illness in the hospital 🔍
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Bash the bug @bashthebug.net · 28/05/2026
Everybody loved the strawberry DNA extractions!🍓 Participants learnt how this technique can be used by scientists to diagnose infections in patients and the data used by doctors to see if the infection has any resistance and then choose which antibiotics to prescribe🧬 @oxfordbrc.bsky.social
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Bash the bug @bashthebug.net · 28/05/2026
We had an amazing time in Westgate, Oxford today! We had many attempts to 'bash the bug' and get the high score for the day on our dance mat 💃🕺 where overusing antibiotics causes resistance so you have to be careful what you're prescribing!💊 #AMR #ScienceOutreach #Microbiology #Oxford
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Bash the bug @bashthebug.net · 27/05/2026
Come see us at the @oxfordbrc.bsky.social showcase! We'll be in Westgate, Oxford 10-3.30. We'll be bringing the dance mat so come and try to beat the germs with antibiotics and claim the high score💃🕺 #AMR #PublicOutreach @ox.ac.uk
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 09/04/2026
Long-read sequencing of Mycobacterial tuberculosis is comparable to short-read sequencing for antimicrobial resistance prediction and epidemiological studies. www.biorxiv.org/content/10.64898/20…
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
TB is preventable and treatable — but only if we can stay ahead of it. #WorldTBDay #Tuberculosis
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
Together, these studies reinforce a clear message: Faster, scalable, and accessible diagnostics are essential — not just to improve individual patient outcomes, but to limit the global spread of resistant TB.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
Using graph neural networks and protein structural data, we’ve also shown how deep learning can improve prediction of pyrazinamide resistance — highlighting the potential of structure-aware models to tackle complex antimicrobial resistance challenges. link.springer.com/article/10.1...
link.springer.com
Predicting pyrazinamide resistance in Mycobacterium tuberculosis using a graph convolutional network - BMC Microbiology
BMC Microbiology - Pyrazinamide is an important first-line antibiotic for treating tuberculosis, with resistance primarily driven by mutations in the pncA gene. Traditional machine learning models...
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
We’ve explored compensatory mutations that can restore bacterial fitness in resistant strains, helping explain how resistant TB continues to spread — and reinforcing the urgency of better diagnostics and stewardship. www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Compensatory mutations are associated with increased in vitro growth in resistant clinical samples of Mycobacterium tuberculosis
Mutations in Mycobacterium tuberculosis associated with resistance to antibiotics often come with a fitness cost for the bacteria. Resistance to the first-line drug rifampicin leads to lower competiti...
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
Our work on bedaquiline resistance (catomatic) provides a reproducible way to construct catalogues of resistance-associated variants — critical for protecting one of the key drugs used to treat MDR-TB. www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
An improved catalogue for whole-genome sequencing prediction of bedaquiline resistance in Mycobacterium tuberculosis using a reproducible algorithmic approach
Bedaquiline (BDQ) has only been approved for use for just over a decade and is a key drug for treating multidrug-resistant tuberculosis; however, rising levels of resistance threaten to reduce its eff...
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
We’ve developed tools like gnomonicus, which translate genomic data into actionable resistance predictions using the WHO catalogue, achieving >95% sensitivity and specificity for two key first-line drugs. www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Characterizing the performance of an antibiotic resistance prediction tool, gnomonicus, using a diverse test set of 2,663 Mycobacterium tuberculosis samples
Tuberculosis remains a global health problem. Making it easier and quicker to identify which antibiotics an infection is likely to be susceptible to will be a key part of the solution. Whilst whole-ge...
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
Our recent preprint shows that Oxford Nanopore sequencing, combined with improved DNA extraction and amplification, can deliver rapid and reliable genomic characterisation directly from clinical cultures — helping move toward real-time TB diagnostics. Read more: www.biorxiv.org/content/10.6...
biorxiv.org
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
The CRyPTIC project has collected and collated over 53,000 TB samples linking genomics with drug susceptibility data — a powerful global resource to accelerate research and improve diagnostics. Find out more: crypticproject.info
crypticproject.info
The CRyPTIC project
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
A major part of tackling TB — especially multidrug-resistant TB (MDR-TB) — is improving how quickly and accurately we can diagnose infections and identify effective treatments. Over the last few years, our work has focused on exactly that:
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
On #WorldTBDay, it’s important to reflect on the scale of the challenge we’re facing. In 2024 alone, tuberculosis (TB) caused 1.23 million deaths worldwide, remaining the leading cause of death from a single infectious agent, according to WHO @ndm.ox.ac.uk
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WHO @who.int · 24/03/2026
Rapid diagnosis of tuberculosis is available and recommended! Early diagnosis is a gamechanger. Ask your provider for access to WHO-recommended rapid tests for TB, including the latest near-point-of-care tests, to ensure a quick diagnosis and early treatment.
Rapid testing of tuberculosis is available & recommended. Early diagnosis is a gamechanger!
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
Open datasets such as these are key for tackling AMR in diseases such as tuberculosis. #WorldTBDay
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Philip Fowler @philipwfowler.bsky.social · 24/03/2026
Since 2017 the CRyPTIC project collected and collated 53,897 clinical TB samples with genetics and drug susceptibility testing data. You can download the datasets via crypticproject.info and v4.0.0 will appear later this year. #WorldTBDay @modmedmicro.bsky.social
crypticproject.info
The CRyPTIC project
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Bash the bug @bashthebug.net · 17/03/2026
Bash the Bug at ATOM Festival: Dancing, Germs, and the Challenge of Antimicrobial Resistance! We had a fantastic time this weekend at ATOM Festival in Abingdon, bringing microbiology to life with our Bash the Bug public engagement activities.
bashthebug.net
Bash the Bug at ATOM Festival
Dancing, Germs, and the Challenge of Antimicrobial Resistance We had a fantastic time this weekend at ATOM Festival in Abingdon, bringing microbiology to life with our Bash the Bug public engagement activities. With plenty of sunshine and a steady stream of curious visitors, it was the perfect setting to spark conversations about one of the biggest challenges in global health: …
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Bash the bug @bashthebug.net · 16/03/2026
It was fantastic to see so many people getting involved, asking great questions, and learning about microbiology in the sunshine. Thanks to everyone who came to say hello, and to our brilliant team for all their enthusiasm! #BashTheBug #Microbiology #PublicOutreach #ATOMFestival
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Bash the bug @bashthebug.net · 16/03/2026
We had a brilliant time this weekend at ATOM Festival in Abingdon! ☀️🦠 We brought along our favourite interactive activities to help people learn about antimicrobial resistance #AMR, including our dance mat game where you fight germs with antibiotics, and we tested everyone’s handwashing skills!
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Philip Bejon @philipbejon.bsky.social · 27/02/2026
1/4 Thrilled to get this metagenomic diagnostic study over the line. We have an in house method that targets RNA viruses in respiratory samples, and evaluated this against 344 prospective samples tested by multiplex PCR. www.medrxiv.org/content/10.6...
medrxiv.org
Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study
Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...
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Nick Sanderson @nickdsandy.bsky.social · 27/02/2026
New preprint from us @modmedmicro.bsky.social where we validate the diagnostic accuracy of a metagenomic nanopore sequencing method for respiratory RNA viruses. www.medrxiv.org/content/10.6...
medrxiv.org
Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study
Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...
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nstoesser.bsky.social @nstoesser.bsky.social · 24/02/2026
Are you a post-doctoral microbiologist interested in characterising bacterial resistance evolution and want to apply your knowledge and expertise to developing new therapeutics for Klebsiella (and other Enterobacterales) infections? Then we need you! Apply now bit.ly/3MX39Ce close date March 13th 👀
my.corehr.com
Job Details
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nstoesser.bsky.social @nstoesser.bsky.social · 25/02/2026
Hoping to innovate community population-level AMR surveillance with the ALARUM team bmjopen.bmj.com/content/16/2.... Can we use metagenomics of pooled colonisation samples to predict clinical AMR burden & inform antimicrobial guidelines?
bmjopen.bmj.com
ALARUM: Active One Health surveillance in LMICs to monitor and predict Antimicrobial Resistance Using Metagenomics – a cross-sectional study protocol
Background In rural sub-Saharan Africa (sSA), the burden of antimicrobial resistance (AMR) remains high. As AMR continues to rise, there is a strong need for practical, implementable surveillance to m...
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Modernising Medical Microbiology @modmedmicro.bsky.social · 11/02/2026
International Day of Women and Girls in Science 👩‍🔬 Proud to work alongside the scientists in our #microbiology lab whose work in antimicrobial resistance, public health and diagnostics has real-world impact! #WomenInScience #AMR #PublicHealth @medsci.ox.ac.uk @ox.ac.uk @oxfordbrc.bsky.social
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Modernising Medical Microbiology @modmedmicro.bsky.social · 09/02/2026
Image taken from doi.org/10.1007/s101...
doi.org
Biofilms on microplastic surfaces and their effect on pollutant adsorption in the aquatic environment - Journal of Material Cycles and Waste Management
The extensive use of plastics has led to the widespread presence of a new type of pollutant called “microplastics (MPs)” in aquatic environments. MPs have large specific surface areas and strong hydro...
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Modernising Medical Microbiology @modmedmicro.bsky.social · 09/02/2026
In this project, you’ll use lab experiments and a microplastics library to explore how bacteria grow and develop antimicrobial resistance in a hospital-like environment. Hands-on microbiology meets a real-world health challenge! www.ox.ac.uk/admissions/g... Life and medical sciences > CLINICAL 04
ox.ac.uk
UNIQplus projects | University of Oxford
Projects available for entry in 2026As part of your UNIQplus Research Internship, you will be working on a project under the supervision of academic staff from our community of world-leading
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Modernising Medical Microbiology @modmedmicro.bsky.social · 09/02/2026
MMM has an exciting UNIQ+ project running this summer -apply now! Bacteria, microplastics & resistance — what’s the connection? #Microplastics are everywhere, even in hospitals. But what happens when bacteria stick to them? Come and find out! @afswinkels.bsky.social @nstoesser.bsky.social
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Cat Baker @catcsb10.bsky.social · 08/02/2026
Happy our preprint is out🦠: "Evaluation of an Oxford Nanopore sequencing workflow for mycobacteria from primary MGIT culture" We developed and tested a workflow for long-read sequencing of #mycobacteria, including optimising DNA extraction and assessing how #ONT performs compared with #Illumina.
biorxiv.org
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nstoesser.bsky.social @nstoesser.bsky.social · 30/01/2026
Our project "Sardinia’s Invisible Marine Microbiome" is one of six 2026 #PartArt4OW participatory art initiatives! Excited to do this with the brilliant @annadumitriu.bsky.social (image credit), Sardinian scientists, citizens of Alghero, and colleagues in @modmedmicro.bsky.social @bashthebug.net
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nstoesser.bsky.social @nstoesser.bsky.social · 26/01/2026
Delighted to be involved in the Gram-Negative Antibiotic Discovery Innovator (Gr-ADI) consortium novonordiskfonden.dk/en/news/new-... as part of a project led by Annette von Delft gcgh.grandchallenges.org/grant/discov... @modmedmicro.bsky.social @samlipworth.bsky.social @philipwfowler.bsky.social
gcgh.grandchallenges.org
Discovery of Novel Klebsiella Hits Through In-Depth Genomic Profiling, Fragment-Based Drug Design and Accumulation Assays
Annette von Delft and collaborators Nicole Stoesser, Lizbe Koekemoer, Ed Griffen, Paul Brennan, Frank von Delft, Phil Fowler, and Thomas Lanyon-Hoggat of the University of Oxford in the United Kingdom...
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