Maslowski MMIMiC Lab @mmimic.bsky.social · 26/09/2025Great news! Abstract deadline is extended till next Friday, 3rd October! 011
Maslowski MMIMiC Lab @mmimic.bsky.social · 23/09/2025Interested in host-microbe interactions and how we can apply findings to develop immunotherapies? The come join us for an exciting workshop in October @cruk-si.bsky.social www.crukscotlandinstitute.ac.uk/events/125-s... 142
Reposted by Maslowski MMIMiC LabProfessor Lesley Hoyles @bugsinyourguts.bsky.social · 13/09/2025If you are UK-based and working on any aspect of microbiomes (human, plant, insect, soil, animal, ...), please do sign up to Microbiome-Net for details of networking, funding and training opportunities. forms.office.com/pages/respon...forms.office.comMicrosoft Forms 23439
Reposted by Maslowski MMIMiC LabJohn Williams @johnhuww.bsky.social · 24/08/2025“High visa fees are putting off some of the world’s most talented scientists from coming to the UK,” said Foulkes, with “We need to be able to compete for the world’s best scientists.” research institutes forced to divert funds from labs to pay fees.” observer.co.uk/news/nationa...observer.co.ukCancer research ‘set back years’ as visa fees drive scien...With vital studies being shelved and foreign experts turning down jobs, leading charity urges ministers to act 22616
Maslowski MMIMiC Lab @mmimic.bsky.social · 09/06/2025Congratulations Cassie and team! Great to see it out, well done. 020
Maslowski MMIMiC Lab @mmimic.bsky.social · 17/05/2025And we did make it! Amazing day! We’re so grateful to all the friends, family and colleagues who helped us reach our fundraising goal! 020
Maslowski MMIMiC Lab @mmimic.bsky.social · 17/05/2025We’re off on the #BigHike! Beautiful day for it, raising money for @cancerresearchuk.org fundraise.cancerresearchuk.org/page/kendles... 250
Maslowski MMIMiC Lab @mmimic.bsky.social · 29/04/2025The team is swapping pipettes for hiking boots to take part in the CRUK Big Hike in the Trossachs in a couple of weeks' time. We'd be grateful for any contributions to the CRUK who fund us and so much vital cancer research! fundraise.cancerresearchuk.org/team/bugs-ag...fundraise.cancerresearchuk.orgBugs against Cancer teamCancer is happening right now, which is why we're fundraising right now for Cancer Research UK. There’s no time to lose! Donate today and help bring forward the day when all cancers are cured. Donatin... 151
Maslowski MMIMiC Lab @mmimic.bsky.social · 25/04/2025Happy big birthday @roscobacterium.bsky.social ! Celebrated in style at lab meeting with Tiramisu made by @celespin.bsky.social 😋 051
Reposted by Maslowski MMIMiC LabSchool of Cancer Sciences @uofgcancersciences.bsky.social · 12/02/2025We are incredibly proud to announce that the School of Cancer Sciences has been awarded the prestigious Athena Swan Gold Award ⭐ 0166
Maslowski MMIMiC Lab @mmimic.bsky.social · 07/02/2025An exciting opportunity to work on gamma deltas in breast cancer👇🏻. A great lab in a great institute! 000
Maslowski MMIMiC Lab @mmimic.bsky.social · 04/02/2025Summary of some our activities by our very own @roscobacterium.bsky.social for world cancer day. 010
Maslowski MMIMiC Lab @mmimic.bsky.social · 24/01/2025Nice write up by CRUK (yet to join Bluesky!) on our recent work! @cruk-si.bsky.social news.cancerresearchuk.org/2025/01/23/f...news.cancerresearchuk.orgFighting fire with fire: could Salmonella treat bowel cancer? - Cancer Research UK - Cancer NewsOur researchers are modifying Salmonella into a treatment that works with the immune system to attack bowel cancer from two sides at once. 020
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024Thanks if you made it this far! This has been a really fun project with lots of twists and turns. Do check it out if it takes your interest! A lot of hard work from Alastair and super collaboration with @bendinglab.bsky.social @sarahdimeloe.bsky.social and thanks to the input from all authors 12/12media.tenor.coma black and white drawing of a cat with the words `` thank you '' written above it .ALT: a black and white drawing of a cat with the words `` thank you '' written above it . 020
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024And this mechanism also fits for E.coli. EV5 shows E. coli Nissle, another popular probiotic and BCT vector also causes aborted T cell activation - so caution I guess if you wanna couple this with checkpoint blockade (as there are no checkpoints to block if T cells are disabled). 11/12 110
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024Before you go - a couple of fun side notes from the sup figures. FIRST, we could have missed this phenotype without the Timer system, EV1 shows comparison with the Nr4a1-GFP and Nr4a1-Timer. GFP gives the impression all is fine bc it sticks around-don't get the info of seeing it turned off. 10/12 111
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024What about back in vivo, can it still work? Well the Asnase-deficient STm still controls tumour growth, despite losing some effect on tumour stemness. SO, bringing T cells back on board is a good thing. That's where this story ends, for now! Much to unpick still! 9/12 110
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024...not quite. Would have been a neat bundle of joy as is, but then we wondered about the effect on the tumour cell...so we looked and yup, Asn depletion is also reducing tumour c-myc...but that's a good thing! Use of the Asnase-KO STm restores tumour c-Myc and 'stemness' 8/12 120
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024After a few rabbit holes we finally pin it down to ASPARAGINE! STm express an asparaginase (as do E. coli), and gobble up asparagine in the TME. T cells REALLY need it (c-myc really needs it). So we remove Asnase and T cells now activate beautifully - JOB DONE?! 7/12media.tenor.coma cartoon drawing of a person wearing a blue jacket with a triangle on itALT: a cartoon drawing of a person wearing a blue jacket with a triangle on it 100
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024What's going on? TCR signal transduction is fine...mTOR/AKT are fine. Finally (took us a while!) we found c-myc was the culprit - T cells in presence of STm TCM could not upreg protein levels required for metabolic switch, so activation aborts....cool....but why? 6/12 110
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024Turn to RNAseq and by 16hrs stim CD4's have failed metabolic reprogramming -> check functionally by seahorse - yep T cells can't upreg glycolysis, oxphos also impaired. This occurs even with just the conditioned medium of STm-infected org's, so it's soluble 5/12 100
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024T cells are dysfunctional. IFNy doesn't correlate with TCR activity, ↓PD-1 & ↓ polyfunctionality. Tumour organoid--T cell co-culture shows arrested TCR signalling after 24-48 hrs aCD3/CD28 stim. What is going on? 4/12 100
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024We used TCR reporter mice (Nr4a3-Timer) crossed with IFNy and induced colonic tumours with AOM/DSS (previous pub Mackie, JCI Insight shows efficacy of attenuated STm in this model). Like others we see ↑CD4 and CD8 infiltration and ↑IFNy...BUT...3/12 100
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/202420 years of literature tells us Salmonella (STm) cancer therapy works just fine (in mice) if there are no T cells - yet many (including us) are looking at ways to target T cells alongside STm. We set out to find out WHY! 2/12media.tenor.coma white cat is sitting on a box with the words `` why why '' written above it .ALT: a white cat is sitting on a box with the words `` why why '' written above it . 100
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024Finally! A🧵for our recent paper 🎉 #Immunosky #microsky #metabolism www.embopress.org/doi/full/10..... A cool host-microbe story, with some fun TCR signalling and metabolism so a bit for everybody. (quite long, so get some popcorn!) 1/12embopress.orgSalmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity | EMBO Molecular MedicineimageimageAttenuated Salmonella show promise as cancer therapeutics, yet T cells play no role in efficacy, limiting combined checkpoint blockade therapies or induction of immune memory. Improving T ce... 12910
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024 First off, we do see ↑CD4&8 infiltration and ↑IFNy...but there's something not quite right...IFNy does not correlate with TCR engagement, and we see poor polyfunctionality. 000
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024We used Nr4a1-Timer TCR reporter mice crossed with an IFNy reporter - then induced colonic tumours using AOM/DSS (prev pub showing STm reduce tumour burden in this model). 100
Maslowski MMIMiC Lab @mmimic.bsky.social · 03/12/2024For a good 20 years, it's been shown that T cells are NOT needed for Salmonella cancer therapy efficacy (in mouse models)...we set out to find out WHY. Why bother? Well combining Salmonella or E.coli vectors with checkpoint blockade therapies is a hot topic atm...(also we'd set out to do just that)media.tenor.coma white cat is sitting on a box with the words `` why why '' written above it .ALT: a white cat is sitting on a box with the words `` why why '' written above it . 100
Maslowski MMIMiC Lab @mmimic.bsky.social · 18/11/2024Thanks Suwannee, not sure what happened to the original link. Hopefully this works. www.embopress.org/doi/full/10....embopress.orgSalmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity | EMBO Molecular MedicineimageimageAttenuated Salmonella show promise as cancer therapeutics, yet T cells play no role in efficacy, limiting combined checkpoint blockade therapies or induction of immune memory. Improving T cell responses requires a better understanding of ... 000
Maslowski MMIMiC Lab @mmimic.bsky.social · 18/11/2024This is a story of duel effect of asparagine depletion on tumour versus T-cell c-myc. A happy ending for T-cells when we delete bacterial asparaginase. CRUK funded, @cruk-si.bsky.social. Thread to follow! 031
Maslowski MMIMiC Lab @mmimic.bsky.social · 18/11/2024Check it out!!! Our work delineating why T cells aren't needed for Salmonella colorectal cancer therapy, and how to get them on board is out 😅🧪🦠. @cruk-si.bsky.social Collab with @bendinglab.bsky.social @sarahdimeloe.bsky.social #Immunosky #Microsky #metabolism www.embopress.org/doi/full/10....embopress.org 2269
Maslowski MMIMiC Lab @mmimic.bsky.social · 18/11/2024This is a story of duel effect of asparagine depletion on tumour versus T-cell c-myc. A happy ending for T-cells when we delete bacterial asparaginase. Thread to follow! 000
Maslowski MMIMiC Lab @mmimic.bsky.social · 15/11/2024Got an exciting team gathered and new work brewing. On this platform @roscobacterium.bsky.social @declanmclelland.bsky.social also Wilma Hoevenaar, Marwa Osman and Taitsu Masunaga and some more in the new year. Some exciting news coming out next week…will keep you posted! 132
Maslowski MMIMiC Lab @mmimic.bsky.social · 15/11/2024Happy to have made the move to where the sky is clear! A bit slow to do so, so very happy to see all the familiar faces as well as new 👋! The lab relocated to the @cruk-si.bsky.social last year, so it’s been busy reforming! 👋 1115