iiinova — where your digital self keeps evolving

mitchell-lab.bsky.social @mitchell-lab.bsky.social · 28/03/2026

So proud of Saloni Modi who won the Kusum Lata Excellence Award for her PhD work @uoftcellsysbiol.bsky.social on pregnancy and labor onset presented at #SRI2026

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Biochemistry and Cell Biology @biochemcellbio.bsky.social · 13/03/2026

🧠 SOX2 is a key #transcription factor for brain development & neural #stem cells—but its enhancers have been all over the map! New review untangles years of data and offers a unified roadmap for understanding SOX2 regulation across species #Neuroscience ow.ly/shyk50YqsEP

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 10/09/2025

Come join us in person for an AI workshop watch party.

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 19/09/2025

The Department of Cell & Systems Biology at University of Toronto invites applications for a full-time tenure stream position in the field of Animal Morphogenesis. #CellBiology #DevelopmentalBiology #mechanobiology #TissueMorphogenesis #SystemsBiology jobs.utoronto.ca/job/Toronto-...

jobs.utoronto.ca

Assistant Professor - Animal Morphogenesis

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Canadian Epigenetics @ceehrc.bsky.social · 19/09/2025

CALL FOR ABSTRACTS! The deadline for abstract submission (for talk consideration), early-bird rates, and travel award applications for the 2025 CEEHRC Annual Meeting is TODAY, FRIDAY, SEPTEMBER 19! event.fourwaves.com/... #epigenetics #ceehrc #epigenomes 1/2

event.fourwaves.com

CEEHRC 11th Annual Canadian Conference on Epigenetics

Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics

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Canadian Epigenetics @ceehrc.bsky.social · 12/09/2025

DEADLINE EXTENDED! Early-bird registration, abstract submission for talk consideration, and travel award application deadline has been extended to FRIDAY, SEPTEMBER 19! Abstracts submitted after Sep 19 will be included in poster sessions. event.fourwaves.com/... 1/2

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 10/09/2025

Come join us in person for an AI workshop watch party.

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Pedro Rocha @pedroprocha.bsky.social · 08/09/2025

🚨🚨🚨 Please repost We are looking for postdocs to join our lab at NIH. Apply: www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply Learn more about training at NIH : www.training.nih.gov/research-tra...

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FragileNucleosome @fnucleosome.bsky.social · 01/09/2025

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...

Fragile Nucleosome Fall Seminars:
September 10 Grace Bower, Kvon Lab @ UC Irvine, USA
Jennifer Phillips-Cremins, UPenn, USA

September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA
Juanma Schvartzman, Columbia University, USA

October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA
Alex Federation, Talus Bio, USA

October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland
Seungsoo Kim, UC Irvine, USA

November 5 Hannah Long, University of Edinburgh, UK
Jeff Vierstra, Altius Institute, USA

November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada
Sarah Teichmann, University of Cambridge, UK

December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain
Jonathan Henninger, Carnegie Mellon, USA

December 17 Rebecca Berrens, Oxford University, UK
Jean-Benoit Lalanne, University of Montreal, Canada

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 08/09/2025

Our latest is online now, we discovered that enhancers cause surrounding chromatin to acquire euchromatin modifications and produce non-coding RNA making regions without enhancer activity look like enhancers. doi.org/10.1101/2025...

doi.org

Enhancers mediate euchromatin hopping at chromatin contact points

Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 15/08/2025

🧪🌱Plants started off as aquatic organisms. But how did they make the jump to land? The Christendat lab show in @molbioevol.bsky.social that SKL1 is necessary for chloroplast formation and this function is conserved in land plants from liverworts to flowering plants! www.utoronto.ca/news/researc...

utoronto.ca

Researchers identify protein that evolved to enable plants to thrive on land

Evolutionary plant biologists at the University of Toronto have identified a protein that evolved approximately 500 million years ago that enables plants to convert light into energy through photosynt...

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 31/07/2025

#DYK there is #SciArt on display around the CSB Buildings @utoronto.ca? Keep your eyes open for gorgeous images created by our @uoftartsci.bsky.social students, from their research and as artwork You can also view these images in our online gallery! csb.utoronto.ca/research-ove...

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Canadian Epigenetics @ceehrc.bsky.social · 24/07/2025

The CEEHRC Annual Meeting returns this fall! Register NOW for the 11th Canadian Conference on Epigenetics taking place November 12-15, 2025 at the Banff Centre for Arts and Creativity in Banff, Alberta. event.fourwaves.com/... 1/7

event.fourwaves.com

CEEHRC 11th Annual Canadian Conference on Epigenetics

Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics

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WHO @who.int · 07/04/2025

It's #WorldHealthDay Since 2000, maternal deaths globally declined by 40%! 💙 BUT—progress is slowing, and aid funding cuts mean major threats to lifesaving maternity services in many parts of the world. ❌

Access alone is not enough; people need high-quality care.

Fewer women are dying in childbirth as access to health care has increased.

Maternity service coverage has increased.

Access to health care saves lives. Pregnancy can be a dangerous time in a woman's life.

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University of Toronto @utoronto.ca · 26/03/2025

Melanie Woodin, an internationally recognized neuroscientist who studies the mechanisms underlying learning and memory in the brain, has been named #UofT’s 17th president. ➡️ uoft.me/uoftpres

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 11/02/2025

As you scroll through our skeets, you’ll see that women scientists are vital to discoveries made at CSB. For International Day of Women & Girls in Science, we’ve highlighted some recent impressive accomplishments #IDWGS2025 #WomenInScience csb.utoronto.ca/supporting-t...

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 30/01/2025

Our work on the enhancers regulating Sox2 in neural stem cells is published! This one has been a long time in the works. We found a cluster of downstream enhancers, including the more well studied SRR2, are required to maintain Sox2 expression and anterior neural identity. doi.org/10.1093/g3jo...

doi.org

A Sox2 Enhancer Cluster Regulates Region-Specific Neural Fates from Mouse Embryonic Stem Cells

Abstract. Sex-determining region Y box 2 (Sox2) is a critical transcription factor for embryogenesis and neural stem and progenitor cell (NSPC) maintenance

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 14/12/2024

Career achievement unlocked - two publications come out on the same day! Great collaboration with Tom Sexton doi.org/10.1126/scia... And fantastic work by Tiegh Taylor and Mitchell lab colleagues journals.plos.org/plosgenetics...

doi.org

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics

Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 14/12/2024

Out now in @ScienceAdvances A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin doi.org/10.1126/scia...

doi.org

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics

Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 14/12/2024

The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells. How are 2 genes separately regulated even though they are fairly close to each other in the genome, we find a primary role for gene separation distance. journals.plos.org/plosgenetics...

journals.plos.org

The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells

Author summary Our study explores how two closely related genes, Lefty1 and Lefty2, are regulated independently despite their proximity in the genome. Both genes play important roles in stem cell main...

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 14/12/2024

Beautiful walk at #AsilomarChromatin this afternoon. Looking forward to the evening session.

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Asilomar Chromatin @asilomarchromatin.bsky.social · 13/12/2024

Always been amazed how cells actually INTENTIONALLY cause double strand breaks. At @asilomarchroma last night, Cheyenne Sadeghi @FrockLab @Stanford showed evidence supporting that during #meiosis, #ATM kinase can suppress translocations after #SPO11 induces the meiotic double strand break.

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Asilomar Chromatin @asilomarchromatin.bsky.social · 13/12/2024

Kicking off the 2024 @asilomarchromatin meeting with Maria Aristizabal Queen’s Univ drilling down on cancer-derived #histone mutations in budding yeast. Affect #genome integrity, transcription, and chromatin compaction! So cool that her first talk was THIS conference when she was an undergrad!

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 09/12/2024

Students in our Stem Cell & Developmental Biology Focus are attending the Medicine by Design Symposium today. A great opportunity to learn about the latest developments in Regenerative Medicine! #MbDSymposium @mitchell-lab.bsky.social

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 15/11/2024

In studies of transcriptional regulation, the Mitchell Lab @mitchell-lab.bsky.social found that redundant systems protected genome integrity no matter what they removed or added to the folded structure linking the essential Sox2 gene with distant regulators csb.utoronto.ca/mitchell-lab...

csb.utoronto.ca

Mitchell lab reveals redundant systems that maintain genome architecture - Department of Cell & Systems Biology

Redundant systems keep genome architecture intact around Sox2 in stem cells and neurons reveal two recent papers from the Mitchell lab

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