Reposted by Michael O’Brien
Cryo-ET is often framed as a tool for in situ protein structure. But what if the real revolution is contextualization?
I explore how #teamtomo is redefining what "local" means in organelle biology, revealing membrane states rather than just protein structures.
tinyurl.com/localmembrane
sciencedirect.com
Think globally, act locally: Redefining organellar membrane environments through cryo-electron tomography
Early enthusiasm for the “cellular revolution” in cryo-electron tomography (cryo-ET) was largely driven by the promise of resolving protein structures…
