Background Individuals with common variable immunodeficiency (CVID) are at increased risk of respiratory infections such as SARS-CoV-2 infection due to poorly understood defects within the memory B ce...

Skin injury releases damage-encoded systemic signals that can initiate immunity to novel antigens introduced at distal barrier sites.

Chimeric antigen receptor (CAR) NK cell therapy has emerged as a promising alternative to CAR T cell therapy, offering significant advantages in terms of safety and versatility. Here we explore the cu...

Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing immune landscape differences between ...

T cells in the brains of Toxoplasma-infected mice are shown to move by Lévy-like walks.

In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...

A few data sources to keep an eye on

Melvyn Bragg and guests discuss the search for immunisation and its impact on society.

NKG2D ligands are widely expressed by solid tumors providing an attractive targeting opportunity with NKG2D-based CAR T cells. Here, Obajdin et al. show that this is optimally achieved using an adapto...