Studies show that chronic low back pain improves in about 15% of patients. Modifiable factors associated with improvement are sleep quality, low psychological distress, and high level of physical acti...

Most early treatments for low back pain do little to prevent chronic pain and disability. No approach reliably stops the transition from acute to chronic pain. This tells us that the mechanisms drivin...

Chronic neck pain is common and difficult to treat, largely because we still poorly understand the biology that sustains it. By studying rare human cervical nerve tissue removed during surgery, we exa...

The research suggests that men’s immune systems have a better mechanism for shutting off pain, which could explain why women have more chronic symptoms.

The research suggests that men’s immune systems have a better mechanism for shutting off pain, which could explain why women have more chronic symptoms.

We have long known that chronic pain has genetic components, but we did not know which types of brain and nerve cells are influenced by these genetic differences in humans. This study aimed to answer ...

Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...

Surgery can lead to chronic pain, likely due to persistent nerve damage, inflammation, and alteration in the processing of pain signals in the spinal cord and brain.

Position DescriptionThe Department of Neuroscience in the School of Behavioral and Brain Sciences at The University of Texas at Dallas seeks a late-stage Associate or Full Professor faculty member to ...

Arendt-Tranholm et al. use surgically resected sensory ganglia to investigate the mechanisms underlying chronic neck pain. They produce a molecular map of

New research highlights the benefits of combining biological and psychosocial measures when identifying biomarkers for pain. This supports the biopsychosocial model and urges a holistic approach to pa...

Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes mellitus that is caused by metabolic toxicity to peripheral axons. We aimed to gain deep mechanistic insight into the disea...

Steroids are commonly administered via injection to help manage chronic pain. But how do they work, and why do they often seem ineffective?

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Background Chronic low back pain (CLBP) and fibromyalgia (FM) are leading causes of suffering, disability, and social costs. Current pharmacological treatments do not target molecular mechanisms drivi...

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

Gabapentin may not increase the risk of death when used with opioids, but its safety profile warrants cautious use.

A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolut...

In a groundbreaking development, the FDA has approved Vertex's suzetrigine for the treatment of moderate to severe acute pain. This approval marks the introduction of a pain medication to the market i...

The limited understanding of the mechanisms underlying human discogenic low back pain (DLBP) has hampered the development of effective treatments. While there is much research on disc degeneration, th...

Muscle relaxants can help manage chronic pain, but not reliably and not in all types of chronic pain.

Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...

Painful diabetic neuropathy commonly affects the peripheral nervous system in individuals with diabetes. However, the pathological processes and mechanisms underlying diabetic neuropathic pain remain ...

Gabapentin and pregabalin are likely overprescribed for pain. They offer pain relief in some patients ,but often cause adverse effects.

Very little is known about the molecular mechanisms underlying chronic neck pain, a highly prevalent and burdensome condition. We analyzed the C2 dorsal root ganglion (DRG) of patients with neck pain ...