Reposted by Brant IsaksonJonathan Jaggar @jaggarlab.bsky.social · 27/03/2026Our review on Potassium Channels in Vascular Smooth Muscle Cells is out at Physiological Reviews. More than 150 pages long and citing more than 1500 articles, this herculean effort was co-authored by Tessa Garrud and Dan Collier. journals.physiology.org/doi/full/10.... 041
Reposted by Brant IsaksonUVA CVRC @uvacvrc.bsky.social · 11/07/2025Why travel to Denmark to collect samples from a giraffe's heart? @brantisakson.bsky.social lab members Skylar Loeb and @lukedunaway.bsky.social made the trip to learn more about diastolic heart failure. Red more: www.cvrc.virginia.edu/cvrc-trainee... #cardiology #medskycvrc.virginia.eduCVRC Trainees Travel Abroad to Collect a Giraffe Heart – Robert M. Berne Cardiovascular Research Center 042
Reposted by Brant IsaksonManuel F. Navedo @mfnavedo.bsky.social · 10/07/2025Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @brantisakson.bsky.social and Xiang Lab 1104
Brant Isakson @brantisakson.bsky.social · 13/06/2025Happy Donut Friday—Love the Cville Donut selections! 🍩 030
Brant Isakson @brantisakson.bsky.social · 05/06/2025🍷 Cheers C’ville! www.nytimes.com/2025/05/28/d...nytimes.comVirginia Is Finally for Wine Lovers 020
Brant Isakson @brantisakson.bsky.social · 07/05/2025Our first giraffe heart acquisition has caused an epic Isakson Lab Slack blowup this morning 🦒🦒 290
Reposted by Brant IsaksonLuke Dunaway @lukedunaway.bsky.social · 24/04/2025Headed to #APS2025! Two great talks tomorrow from the Isakson Lab in the MCS session. Wyatt Shug (8:30AM) will present on basophil-endothelial crosstalk, and Skylar Loeb (10:50AM) will present the novel identification and impact of hemoglobin-alpha in cardiac lymphatics. @brantisakson.bsky.social 171
Reposted by Brant IsaksonStirling Churchman @stirlingchurchman.bsky.social · 21/04/2025My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...wsj.comOpinion | Science Suffers With Trump’s Funding FreezeAmerica’s scientific enterprise demands reliable stewardship, not destabilizing political intervention. 3177139
Brant Isakson @brantisakson.bsky.social · 21/04/2025Some of the strong work by Melissa Luse rounding her PhD. Love the story, and I think it opens up some new ideas in endothelial lipid handling and overall questions roles for NO… www.ahajournals.org/doi/10.1161/...ahajournals.orgNitrosation of CD36 Regulates Endothelial Function and Serum Lipids | Arteriosclerosis, Thrombosis, and Vascular BiologyBACKGROUND: During obesity, endothelial cells (ECs) become lipid laden, leading to endothelial dysfunction. We tested posttranslational modification on CD36 that may regulate EC lipid accumulation. ... 061
Reposted by Brant IsaksonUVA CVRC @uvacvrc.bsky.social · 04/04/2025Want to stay current with cardiology at UVA? Check out our starter pack! If you're a cardiologist at UVA and want to be included in the list, DM us! go.bsky.app/3NVEjJ5 022
Reposted by Brant IsaksonUVA CVRC @uvacvrc.bsky.social · 20/03/2025@lukedunaway.bsky.social, PhD, recently received an @americanheart.bsky.social Career Development Award to study iron's role in chronic kidney disease. Luke is a postdoc in @brantisakson.bsky.social's Lab and member of our Cardiovascular Training Program. Congratulations! #CardioSky #MedSkycvrc.virginia.eduLuke Dunaway, PhD, Wins AHA Award for Chronic Kidney Disease Research – Robert M. Berne Cardiovascular Research Center 075
Brant Isakson @brantisakson.bsky.social · 21/02/2025Happy Donut Friday! C’ville’s very own Belle for the win… 170
Brant Isakson @brantisakson.bsky.social · 07/02/2025some good distraction tonight from the political crazies 0160
Reposted by Brant Isaksonferrutxoart.bsky.social @ferrutxoart.bsky.social · 26/01/2025Qunkasaura is the last dinosaur described in Spain, a large titanosaur that lived alongside Lohuecotitan at the Lo Hueco site, in the province of Cuenca #paleoart 24716
Brant Isakson @brantisakson.bsky.social · 07/01/2025🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕 0204
Brant Isakson @brantisakson.bsky.social · 20/12/2024Happy Donut Friday to these three! Zuza received an AHA for work on Piezo2, Wyatt received BOTH an AHA and a F31 for work on basophils, and Skylar received an F31 for work on lymphatic alpha globin! Honored to have them in lab! (Pic from 2024 NAVBO) 0180
Brant Isakson @brantisakson.bsky.social · 12/12/2024Delighted to share ongoing translation of our discovery that alpha globin-eNOS is a potent regulator of NO in endothelium. In this work, the mechanism is confirmed in humans with alpha thalassemia, and our HbaX peptide used to dilate sickle cell arteries n/🧵 www.ahajournals.org/doi/abs/10.1...ahajournals.orgSickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions | CirculationBACKGROUND: Severe malaria is associated with impaired nitric oxide (NO) synthase (NOS)–dependent vasodilation, and reversal of this deficit improves survival in murine models. Malaria might have sele... 152
Reposted by Brant IsaksonTimothy Hla @hlatim.bsky.social · 18/11/2024Exciting Gordon conference on vascular cell biology - Jan 2025 in Ventura, CA org by Karen Hirschi, @UVA www.grc.org/vascular-cel...grc.org2025 Vascular Cell Biology Conference GRCThe 2025 Gordon Research Conference on Vascular Cell Biology will be held in Ventura, California. Apply today to reserve your spot. 1148