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Michael Metzger

@metzgerm.bsky.social
580 followers 642 following 167 posts

Assistant Investigator at the Pacific Northwest Research Institute. Clamcer and other things. Opinions my own.

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Michael Metzger @metzgerm.bsky.social · 13/10/2026
Great. Now I need to get one of these just so that I can carve a butter mummy at Halloween.
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Michael Metzger @metzgerm.bsky.social · 10/10/2026
Nice! I missed that earlier
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Michael Metzger @metzgerm.bsky.social · 09/10/2026
Years ago I made phylogenetic trees of mtDNA and threw in lots of very different reference sequences. It turned out that due to deep split of bivalves and their higher mtDNA mutation rate, the genetic distance between clam and mussel COI sequence was greater than between clams and humans.
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Michael Metzger @metzgerm.bsky.social · 08/10/2026
Good point. It is easy to forget how divergent bivalves really are!
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Michael Metzger @metzgerm.bsky.social · 08/10/2026
Cool article on all FOUR types of transmissible cancers by Nala Rogers knowablemagazine.org/content/arti...
knowablemagazine.org
Dogs, devils, clams and catfish: When cancer is contagious
In a handful of animals, tumors can be transmitted like infectious diseases or parasites, defying science’s tidy definitions
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Michael Metzger @metzgerm.bsky.social · 30/09/2026
In case anyone was wondeing, I just saw the announcement that the change in Letters of Support for NIH grants to a new NSF-style that was supposed to start at the begining of FY2027 (i.e. now) will be delayed. "Implementation is expected before the end of FY 2028." So no change for now.
grants.nih.gov
Letters of Collaboration to Replace Letters of Support | Grants & Funding
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Katrina Velle @katrinavelle.bsky.social · 29/09/2026
Heads up to other October NIH deadliners-- if you didn't do this already it appears you do not have to.
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Michael Metzger @metzgerm.bsky.social · 30/09/2026
Big day! Congratulations both of you!
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Melissa Kane PhD @cornymel.bsky.social · 30/09/2026
My first PhD student is defending his dissertation in two weeks!! There will be mouse genetics, there will be retroviruses, there will be B and T cells, there will be champagne, there will be me trying (and likely failing) not to cry the whole time.
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Jeremy Van Cleve @vancleve.theoretical.bio · 29/09/2026
My group is recruiting a Ph.D student for Fall 2027! We're a friendly group of mathematically-minded and computationally-inspired biologists studying topics including social evolution, host-pathogen interactions, genetics, and demography. See vancleve.theoretical.bio for more info!
vancleve.theoretical.bio
van cleve research group
Van Cleve Research Group – theoretical evolution & ecology at the University of Kentucky
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Michael Metzger @metzgerm.bsky.social · 29/09/2026
Congratulations!
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Maitreya Dunham @maitreya.bsky.social · 24/09/2026
Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.
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Vaughn Cooper @vscooper.micropopbio.org · 25/09/2026
FYI to everyone submitting this October NIH cycle You need to re-certify your ScienCV AFTER Sept 26 (tomorrow) for your application or it may not be accepted. Great timing!
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Harmit Singh Malik @harmitmalik.bsky.social · 21/09/2026
If you have questions about this search, please contact me or @suebiggins.bsky.social by email. In addition to the Bezos Scholar position, we're also hiring at the Assistant (starting) and Associate Professor levels in any area of fundamental biology: apply.interfolio.com/190640 Please repost!
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Michael Metzger @metzgerm.bsky.social · 21/09/2026
Does anyone know when the NIH switch from “letters of support” to “letters of collaboration” happens?
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Michael Metzger @metzgerm.bsky.social · 17/09/2026
Thanks, Dan.
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Michael Metzger @metzgerm.bsky.social · 15/09/2026
GRFP question: Does anyone have any advice for what students can say in broader impacts now that most specific broader impacts have been put on the exclusion list?
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Dr. Jessica L Ware @jessicalwarelab.bsky.social · 11/09/2026
Come work here, it is a fun place and we would love to have you as our colleague: careers.amnh.org/postings/4923 #Lepidoptera #Insect #Entomology #AMNH
careers.amnh.org
Assistant Curator/Assistant Professor, Invertebrate Zoology
The Division of Invertebrate Zoology at the American Museum of Natural History (AMNH) seeks an outstanding tenure-track Assistant Curator/Assistant Professor with expertise in the evolution of Lepidop...
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Joshua Weitz @joshuasweitz.bsky.social · 25/08/2026
NSF just announced its GRFP solicitation due in October - deadline varies by field: www.nsf.gov/funding/oppo... Now for the bad news... * NSF estimates they will issue 1,500 awards, down from 2,500+ last year. * NSF removed STEM Education and Learning Research as a Major Field.
nsf.gov
NSF Graduate Research Fellowship Program (GRFP)
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Harmit Singh Malik @harmitmalik.bsky.social · 21/08/2026
@hhmi-science.bsky.social has several upcoming competitions for scientists at various career stages. Here is a list (pl share whatever you feel will be useful): 1) Rising college juniors & seniors in summer 2027 can apply to the Cech Fellows program (www.hhmi.org/programs/cec...) Deadline: Nov 10
hhmi.org
Summer Undergraduate Research Experience (REU) | Cech Fellows | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
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Carl Zimmer @carlzimmer.com · 30/07/2026
For a disease as spectacularly scary as smallpox, its history is remarkably mysterious. Here is my look at what ancient DNA from the viruses is revealing. Gift link: nyti.ms/4vTU11D
nyti.ms
‘This Is Very Strange’: Ancient Smallpox May Have Been Less Deadly (Gift Article)
Scientists have found smallpox viruses in the remains of people in Chile from around 500 years ago, revealing how the virus may have evolved into a global killer.
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Michael Emerman @memerman.bsky.social · 27/07/2026
My very last, last author paper now published a year since retirement. All credit to grad Caroline Langley who did brilliant work, super tech Michelle Lily who finished the experimental work after Caroline graduated, and my ever wise collaborator (and Caroline’s co-mentor) @harmitmalik.bsky.social
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Carl Zimmer @carlzimmer.com · 22/07/2026
Link to study: www.nature.com/articles/s41...
nature.com
Brown bullhead catfish melanoma represents a novel transmissible cancer - Nature
Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.
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Michael Metzger @metzgerm.bsky.social · 22/07/2026
Welcome a fourth type of transmissible cancers, after the ones in devils, dogs, and bivalves: Fish transmissible melanoma in brown bullhead! Congrats to Julie Dragon and her team on this cool finding!
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Carl Zimmer @carlzimmer.com · 22/07/2026
Did Thoreau encounter contagious cancer? A new study finds transmissible tumors in catfish--and raises questions about whether they could arise in humans someday. Gift link: nyti.ms/4whfi6v
nyti.ms
Deep in This Lake, a Contagious Cancer Is Spreading (Gift Article)
Transmissible tumors have been reported in a handful of animal species, but never before among fish. Is it possible in humans?
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Aris Katzourakis @ariskatzourakis.bsky.social · 08/07/2026
Completed our work on reconstructing the viral histories of human, simian and prosimian immunodeficiency viruses across multiple evolutionary timescales, with @mghafari.bsky.social & @psimmond.bsky.social royalsocietypublishing.org/rspb/article...
royalsocietypublishing.org
Reconstructing the viral histories of human, simian and prosimian immunodeficiency viruses across multiple evolutionary timescales
Abstract. The evolutionary history of simian and prosimian immunodeficiency viruses (SIVs and pSIVs) remains difficult to resolve, because divergence-time
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Dr. Carly Kenkel @drcarl.bsky.social · 03/06/2026
The list of Ecology/Evolution/Marine Bio Labs recruiting grad students for Fall 2027 is live! PIs enter your position info here: forms.gle/MAGd4ohyPeoY... students (and PIs not recruiting) share the composite list: docs.google.com/spreadsheets... Please share widely! 🧪
forms.gle
Ecology/Evolution/Marine Biology labs recruiting for Fall 2027
Please complete this form if you are a PI recruiting graduate students for a Fall 2027 start. If you are NOT recruiting, feel free to share the response sheet with prospective students looking for lab...
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Michael Metzger @metzgerm.bsky.social · 02/07/2026
Our crew was back out at low tide yesterday, collecting clams to bring to the lab to see if this transmissible cancer outbreak is starting to decrease after the peak of >75% prevalence or if it is still high. Very curious to see how this population evolves as we watch this outbreak in real-time.
Soft-shell clams lined up after collected from a beach on Camano Island
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Richard Lenski @relenski.bsky.social · 11/05/2026
New book "A Primer for Experimental Evolution" with coauthors Michael Rose, Margarida Matos, and Joe Graves. www.worldscientific.com/worldscibook... A compact primer for students and colleagues interested in planning and designing experiments to address questions in evolutionary biology.
worldscientific.com
A Primer for Experimental Evolution
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Neil Shubin @neilshubin.bsky.social · 25/06/2026
My editorial in this week’s Science @aaas.org www.science.org/doi/10.1126/... 🧪
science.org
The enduring pursuit of science in America
Imagine an American organization that convenes scientific experts not to advance any ideology or interest but to provide the nation with a clear understanding of complex problems. Imagine this body wo...
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Michael Metzger @metzgerm.bsky.social · 25/06/2026
It feels weird to be talking about our science in the middle of all of … this. But we are trying to keep it going the best we can.
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
This was all supported mostly by an ongoing grant from the NSF’s Ecology and Evolution of Infectious Diseases Program. Wish us luck in the future. Hopefully we are able to find out where all this leads. 14/14
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
This was a huge collaboration, led by Zach and Sydney, with a lot of work from Franchesca Perez, shellfish biologist with Stillaguamish Tribe, Jay Dimond from WWU, and many others--including the work of three REU students, Dorothy Lartey, Angel Santos, and Holden Maxfield! 13/14
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
We have some evidence suggesting that the M. japonica are less susceptible to BTN than M. arenaria, so we plan to continue to follow this outbreak and sequence the genomes of the surviving clams over time. 12/14
Figure showing trend of lower prevalence of BTN in clams with M. japonica genetic markers (not significant).Plot showing correlation between detection of BTN in seawater and the fraction of the soft-shell clam eDNA that is M. arenaria.
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
The good news for science is that catching this outbreak right as it starts gives us a really unique opportunity to learn how this disease spreads and also how these hybridizing populations will evolve resistance to this lethal cancer in real time as we (hopefully) continue to study them. 11/14
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
This outbreak has had huge effects on these clam populations and has caused the commercial collection of soft-shell clams in Skagit Bay to collapse. This is bad news for the clams and for the people and communities that rely on them. 10/14
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
The eDNA showed the BTN outbreak is centered around the 2 sites where we found infected animals, with spread around these sites. It also showed that the BTN is not found throughout all of Puget Sound—We hope to continue to use these methods to study how this cancer spreads in new populations. 9/14
Fig 5.   Spatial distribution of MarBTN outbreak shown by broad eDNA surveys across the Puget Sound. Multi-panel figure with maps of eDNA throughout Puget Sound.
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
We then used this assay to quantify both the spread of the infectious cancer and the distribution of the two different species of soft-shell clams (based on mtDNA SNPs). 8/14
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
We wanted to know how far it all went, so we made qPCR primers for BTN-specific mtDNA SNPs and developed an environmental DNA (eDNA) assay that can sensitively detect the presence of transmissible cancer in wild water samples. 7/14
Fig 4. Detection of BTN in environmental DNA (eDNA) at a site of disease outbreak. Muli-panel figure with maps of Triangle Cove with eDNA values plotted on them.
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
Then came the second unexpected part. When we sequenced COI and a nuclear marker to verify the species identity we found that there were actually both Mya arenaria and Mya japonica in these sites—and there were heterozygous animals too! Hybridization! 6/14
Fig 3. Identification of hybridizing populations of M. arenaria and M. japonica in Puget Sound. Multi-panel figure with phylogenetic trees and tables of genotypes
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
We used PCR to identify genetic markers of the 2 known sublineages (New England & PEI)—we confirmed that the cancer cells here did come from the same sub-lineage that is in New England. It was most likely accidentally transported over here, but we don’t have any idea how at this point. 5/14
Fig 2. Transposon insertions show BTN in soft- shell clams in Puget Sound is from the USA sublineage of MarBTN. Multi-panel figure with phylogenetic tree and gel images of PCR products.
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
We found it in South Skagit Bay as well, and the prevalence in both sites went up in 2023 and to >75% in 2024. But it wasn’t found in other clams further away. 4/14
Fig 1. Detection of BTN in soft- shell clams (Mya sp.) in Puget Sound, Washington State, the United States. Multi-panel figure with map and charts of prevalence over time.
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
This project started when we collected soft-shells on Camano Island, in Puget Sound in 2022, expecting to use them as negative controls, but instead found >40% of the clams had cancer! There haven’t been reports of prevalence this high in any soft-shell clam populations in decades. 3/14
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
We had first identified bivalve transmissible neoplasia in soft-shell clams (Mya arenaria) on the East Coast back in 2015, although it has been around for a lot longer than that (called disseminated neoplasia). Soft-shells are on the West Coast, but no one had reported any disease in them. 2/14
cell.com
Horizontal Transmission of Clonal Cancer Cells Causes Leukemia in Soft-Shell Clams
A fatal form of cancer is spreading between animals in the marine environment as a clonal horizontally transmissible cell, likely derived from a single original clam.
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Michael Metzger @metzgerm.bsky.social · 23/06/2026
I am excited to present our newest report on a severe outbreak of transmissible cancer in clams in the Pacific Northwest, with a lot of unexpected twists. Led by Sydney Weinandt and Zach Child. www.pnas.org/doi/10.1073/pnas.2611852123 1/14
pnas.org
Atlantic to Pacific: Outbreak of bivalve transmissible neoplasia detected in hybridizing soft-shell clams and eDNA in Puget Sound | PNAS
Bivalve transmissible neoplasias (BTNs) are transmissible cancers that have arisen in multiple bivalve species, including Eastern soft-shell clam (...
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Karolin Luger @nucleosomepolice.bsky.social · 20/06/2026
Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...
nytimes.com
Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack
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Michael Metzger @metzgerm.bsky.social · 18/06/2026
This whole thing made me realize just how much of an imposter syndrome feedback system this is. It feeds on people who feel they are imposters, and promises them it will help, but instead it makes their imposter syndrome grow, so they need it even more.
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Jason Rasgon @vectorgen.bsky.social · 16/06/2026
If anyone is looking specifically to work on developing novel transgenesis and genetic control methods for screwworm, that is a plus. Apply!
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Michael Metzger @metzgerm.bsky.social · 12/06/2026
I still remember reading that Roethke bat poem in school that ends by saying that bats are mice with wings that wear a human face, and just thinking “What on earth are you talking about? Has this guy ever seen a real bat?”
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Michael Metzger @metzgerm.bsky.social · 12/06/2026
For the second time this week I wish I could just run over to City People’s to pick something up. But alas, they didn’t make it after too many switched to buying things online. Support your local shops, folks. You never know when you will need to buy a replacement toilet flapper quickly!
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