Human pathology is a result of complex processes that depend on the interplay between malignant cells, stroma, and the immune system, which can act both to suppress and promote various diseases, inclu...

Seehawer et al. show that deletion of Kmt2c or Kmt2d promotes brain metastasis in mouse models of triple-negative breast cancer due to altered KDM6A activity and upregulated MMP3 expression, which may...

In mice, tumor cells can metastasize to distant organs by entering blood vessels within the local lymph node.

Lei et al. uncover that a subpopulation of breast cancer cells in the lymph node is marked by MHC-II expression in the absence of costimulatory molecules,

Edwin L. Steele Laboratories

Evans, Blake, Longworth and colleagues identify and characterize a tumour-suppressive role for microglia that mediate a pro-inflammatory response to restrict brain metastasis in breast cancer.

Co-option of HER2 signaling in the bone microenvironment drives metastatic cross-seeding by promoting HER2-expressing circulating tumor cells in HR+/HER2− breast cancer.

Our laboratory seeks to understand the interplay between tumor microenvironment and metastasis plasticity in breast cancer. We use a multidisciplinary approach to investigate the mechanisms of intra-t...