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Madeleine Kline

@mckline98.bsky.social
138 followers 167 following 22 posts

MD/PhD student at HMS/HSPH infectious disease epidemiology, musician, climate advocate, runner, lover of baked goods and cute animals

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Reposted by Madeleine Kline
CCDD @ccdd-hsph.bsky.social · 09/01/2026
New publication! Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study featuring authors: @mckline98.bsky.social, @kroster.bsky.social, @dhelekal.bsky.social, @rumpl-er.bsky.social, and @yhgrad.bsky.social. Read it here at bit.ly/3Z1Zplh
bit.ly
Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study
Immediately introducing 2 new antibiotics to treat gonorrhea alongside 1 currently used therapy is more effective at minimizing drug resistance than holdin
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Reposted by Madeleine Kline
Department of Immunology and Infectious Diseases, Harvard T.H. C @harvard-iid.bsky.social · 16/12/2025
Please join our department in wishing Madeleine Kline (@mckline98.bsky.social) the best on her dissertation defense today! 👏
Madeleine Kline. Date and time: Tuesday, December 16th, 2025 at 10 am - 12 pm ET. Location: Harvard Chan - FXB 301. “From Spatial Spread to Sexual Networks: Leveraging Infectious Disease Epidemiology Tools to Monitor and Respond to Strep Throat and Gonorrhea”
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Reposted by Madeleine Kline
Nicola Low @nicolamlow.bsky.social · 12/12/2025
🧪 #gonorrhoea #mustread today's news about 2 new drugs to treat #gonorrhoea Thanks @kakape.bsky.social for opportunity to say, "The availability of two new drugs will lead to an important and likely controversial debate about how best to use them" And to @yhgrad.bsky.social @gardp.bsky.social
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Reposted by Madeleine Kline
Nicola Low @nicolamlow.bsky.social · 12/12/2025
🧪 #Zoliflodacin a truly new #antibiotic just for #gonorrhoea Maybe even more important is the controversial debate about how best to use it We work with UZH, @yhgrad.bsky.social and @gardp.bsky.social to model the best strategies in 🇿🇦 @ispm.unibe.ch @unibe.ch www.science.org/content/arti...
science.org
New antibiotic for gonorrhea could help beat back drug-resistant infections
Two treatments for the sexually transmitted disease are expected to become available soon
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Reposted by Madeleine Kline
PLOS Climate @plosclimate.org · 02/12/2025
New article by Natalie Baker and colleagues: "Evaluating the impact of a longitudinal, integrated climate change, health, and environment curriculum in undergraduate medical training at Harvard Medical School" journals.plos.org/climate/arti... @gaurabbasu.bsky.social @mckline98.bsky.social
journals.plos.org
Evaluating the impact of a longitudinal, integrated climate change, health, and environment curriculum in undergraduate medical training at Harvard Medical School
Climate change, air pollution, and ecological degradation are defining public health and health equity challenges of our time. Efforts to integrate and evaluate climate change curriculum in medical ed...
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Reposted by Madeleine Kline
Department of Immunology and Infectious Diseases, Harvard T.H. C @harvard-iid.bsky.social · 30/07/2025
In April, we congratulated IID’s Madeleine Kline (“Maddy”) on achieving the Emerging Physician Leader Award and Scholarship from Health Care Without Harm. 👏Learn more about the award and this year’s inspiring recipients here: 🔗 us.noharm.org/initiatives/.... (@mckline98.bsky.social)
us.noharm.org
Health professional awards, scholarships, & fellowships | Health Care Without Harm - US & Canada
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Madeleine Kline @mckline98.bsky.social · 18/07/2025
Your point about higher starting prevalence settings is also excellent — and an area of ongoing work in the lab!
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Madeleine Kline @mckline98.bsky.social · 18/07/2025
However, this would effectively mean there is a higher “resistance emergence” probability to those drugs, which we did test in our sensitivity analysis. Our framework could be easily adapted to more specifically look at bystander selection via something like an importation rate parameter.
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Madeleine Kline @mckline98.bsky.social · 18/07/2025
Thanks so much! It’s true that bystander selection through antibiotic usage for non-gonorrhea infections could occur (especially for ceftriaxone and gepotidacin), and this is not explicitly modeled here.
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
Our results indicate that distributing selective pressures across the population minimizes the emergence of drug resistance in gonorrhea in US MSM and underscore the importance of disease and context-specific decision-making. [10/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
It was possible to find combinations of parameters where equal allocation was worse than sequential, but these were rare edge cases that required a combination of unlikely events. Even then, the difference between strategies was not large [9/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
Equal allocation was still better when we changed the prevalence threshold from 5% to 1% or 10%, and across a wide range of parameter values for parameters that determine underlying model behavior [8/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
The sequential strategy had met the 5% resistance prevalence threshold i) for each drug individually and ii) for all 3 drugs in at least as many simulations and iii) for at least as many drugs on average compared to the equal allocation strategy [7/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
We looked at the proportion of simulations had reached 5% prevalence of resistance for each drug and found that the equal allocation strategy 🔴 was better than the sequential strategy 🔵 because: [6/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
We compared two strategies: equal allocation 🔴, where all 3 drugs are used in random allocation but each individual gets treated with 1 drug, and sequential 🔵, where new drugs are only used once resistance prevalence for the previous drug has reached 5% [5/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
Here, we used a stochastic compartmental gonorrhea transmission model of US MSM to test introduction strategies with two new available drugs and one currently used drug, aimed at capturing random emergence and extinction dynamics [4/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
Antibiotic stewardship often urges us to reserve new antibiotics until they are absolutely needed, especially in hospital settings. Past research has shown that for gonorrhea treatment, distributing selective pressures by offering more treatment options at the same time reduces drug resistance[3/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
There were > half a million notifications for gonorrhea in the US in 2023, and the bacteria that cause the infection have developed resistance to all antibiotics used to treat it. 2 new drugs, zoliflodacin and gepotidacin, had positive phase III trial results and will likely be approved soon [2/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
⚠️ New preprint ⚠️: Two new antibiotics are likely coming for gonorrhea 💊. How should we deploy them in the US to minimize drug resistance? @kroster.bsky.social @dhelekal.bsky.social Eva Rumpler @yhgrad.bsky.social [1/10] www.medrxiv.org/content/10.1...
medrxiv.org
Comparing Strategies to Introduce Two New Antibiotics for Gonorrhea: A Modeling Study
Introduction Drug resistance in Neisseria gonorrhoeae is an urgent public health threat. The anticipated approval of two new antimicrobials for gonorrhea prompts the need for evidence-based rollout st...
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
Our results indicate that distributing selective pressures across the population minimizes the emergence of drug resistance in gonorrhea in US MSM and underscore the importance of disease and context-specific decision-making. [10/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
It was possible to find combinations of parameters where equal allocation was worse than sequential, but these were rare edge cases that required a combination of unlikely events. Even then, the difference between strategies was not large [9/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
We looked at the proportion of simulations had reached 5% prevalence of resistance for each drug and found that the equal allocation strategy 🔴 was better than the sequential strategy 🔵 because: [6/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
We compared two strategies: equal allocation 🔴, where all 3 drugs are used in random allocation but each individual gets treated with 1 drug, and sequential 🔵, where new drugs are only used once resistance prevalence for the previous drug has reached 5% [5/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
Here, we used a stochastic compartmental gonorrhea transmission model of US MSM to test introduction strategies with two new available drugs and one currently used drug, aimed at capturing random emergence and extinction dynamics [4/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
Antibiotic stewardship often urges us to reserve new antibiotics until they are absolutely needed, especially in hospital settings. Past research has shown that for gonorrhea treatment, distributing selective pressures by offering more treatment options at the same time reduces drug resistance[3/10]
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Madeleine Kline @mckline98.bsky.social · 03/07/2025
There were over 1/2 a million notifications for gonorrhea in the US in 2023, and the bacteria that cause the infection have developed resistance to all antibiotics used to treat it. 2 new drugs, zoliflodacin and gepotidacin, had positive phase III trial results and will likely be approved soon[2/10]
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Reposted by Madeleine Kline
Bailey Bowcutt @baileybowcutt.bsky.social · 22/05/2025
I'm a current Harvard graduate student and I found out today that I had my NSF GRFP terminated without notification. I was awarded this individual research fellowship before even choosing Harvard as my graduate school
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Reposted by Madeleine Kline
Kirstin Oliveira Roster @kroster.bsky.social · 21/05/2025
New preprint. After years of increases, gonorrhea diagnosis rates dropped in the US in 2022 and 2023. While the news is promising, understanding WHY is key to sustaining progress. dash.harvard.edu/handle/1/427...
dash.harvard.edu
Why are gonorrhea diagnoses declining in the US?
After a decade of rising cases, the US CDC reported a decline in the rate of gonorrhea diagnoses for two years in a row in 2022 and 2023, especially among young adults. Primary and secondary syphilis ...
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Reposted by Madeleine Kline
Harvard T.H. Chan School of Public Health @hsph.harvard.edu · 16/05/2025
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
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Reposted by Madeleine Kline
Scott Delaney @scott-delaney.bsky.social · 14/05/2025
My ongoing request: If your NSF or NIH grant was terminated--whether at Harvard or elsewhere--please report it here. NSF: grant-watch.us/submit-nsf.h... NIH: grant-watch.us/submit-nih.h... Our trackers are actively used in lawsuits and are often the only record that terminations ever occurred.
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Reposted by Madeleine Kline
Harvard Epidemiology @harvardepi.bsky.social · 14/05/2025
We are excited to announce this year's Teaching Fellow Awardees!. Excellence in Teaching: @ruchitabalasub1.bsky.social, Eva Rumpler, and Anna Siefkas. Certificates of Distinction: @mckline98.bsky.social, Sharon Ng, and Andrew Weckstein. Congratulations to all! 🎉
Congratulations banner with gold, navy blue and white background.
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Madeleine Kline @mckline98.bsky.social · 01/05/2025
I’m so thrilled to be one of Health Care Without Harm’s 2025 Emerging Physician Leader Award recipients. Excited for CleanMed next week! @harvardcchange.bsky.social @harvardmitmdphd.bsky.social @hsph.harvard.edu @harvardepi.bsky.social @ccdd-hsph.bsky.social us.noharm.org/news/health-...
us.noharm.org
Health Care Without Harm Announces 2025 Sadler Fellows and Emerging Physician Leader awardees | Health Care Without Harm (US & Canada)
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Madeleine Kline @mckline98.bsky.social · 25/04/2025
Today Natalie Baker presented our work towards clean energy solutions in the Longwood Medical Area at the Thriving Together conference at BU and received this award! So proud of this team! @bumedicine.bsky.social @harvardcchange.bsky.social @harvardmed.bsky.social @hsph.harvard.edu
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Reposted by Madeleine Kline
David Helekal @dhelekal.bsky.social · 28/03/2025
(1/10) New preprint: Expansion of tetM-carrying Neisseria gonorrhoeae in the US, 2018-2024; Link: www.medrxiv.org/content/10.1...
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Reposted by Madeleine Kline
CommonWealth Beacon @cwbeacon.bsky.social · 17/02/2025
ICYMI: Harvard, other Mass. institutions should clean up their own backyard before trumpeting clean energy efforts elsewhere by Regina LaRocque, Mariel Tai Sander, Avi Cohen and Madeleine Kline #opinion buff.ly/4jX5qZL
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