Matthew Russell @matteomics.bsky.social · 02/10/2026My day feels very much like this! Although I only have a cold, Darwin was dealing with worse. 000
Matthew Russell @matteomics.bsky.social · 28/09/2026Sometime the real potential benefit of "reproducibility" is really auditability. The possibility of laying out the data and the steps for critical appraisal. The reproducibility makes that audit possible, it is not a magic test on its own. 091
Reposted by Matthew RussellColette Delawalla, PhD @cdelawalla.bsky.social · 28/09/2026The humanities have been calling out genAI theft since the jump, while STEM has rallied around “discovery potential”. I am *ONCE AGAIN* reminding EVERYONE that science is not the sacred cow, STEM isn’t the exception. They are going to steal our IP, too. We aren’t special. 8371150
Matthew Russell @matteomics.bsky.social · 28/09/2026I think LLM finding and linking up research a single individual might never consider together, which maybe is what these stories really are, might actually support academic idea generation. But that use case can't justify or repay the trillions invested. 000
Matthew Russell @matteomics.bsky.social · 24/09/2026Really makes the case that various grades of #masspec based #proteomics could be useful at different points in #biotechnology development and processing monitoring. The next paper will show what I think is a really cool example. 001
Matthew Russell @matteomics.bsky.social · 24/09/2026So paper published! From Discovery Proteomics to Process-Informed Monitoring in Biomanufacturing Chassis Development pubs.acs.org/amachv/artic...pubs.acs.orgFrom Discovery Proteomics to Process-Informed Monitoring in Biomanufacturing Chassis DevelopmentAbstract. Gaining control of existing biomanufacturing chassis organisms, such as Escherichia coli K12, and novel isolates, such as the salt-tolerant Halom 110
Matthew Russell @matteomics.bsky.social · 23/09/2026The first one has strong Diana and Actaeon vibes. Actaeon is turned by the Goddess of the hunt into a dear who is brought down by his own hounds. en.wikipedia.org/wiki/Diana_a...en.wikipedia.orgDiana and Actaeon - Wikipedia 000
Matthew Russell @matteomics.bsky.social · 21/09/2026The UK BBC has a talk radio channel called Radio 4 very middle aged middle class. It has a feedback programme where people who blatantly have R4 on as a constant background in their lives write in to complain about it. Similar phenomena I think. 020
Matthew Russell @matteomics.bsky.social · 14/09/2026What does it say about me that my first thought was "deep fry" 000
Matthew Russell @matteomics.bsky.social · 14/09/2026This is surely the same guy who ends up with Sarena Williams serving a ball cleanly through his skull when he thinks he can win a point from her. Great writing btw. 0110
Matthew Russell @matteomics.bsky.social · 12/09/2026I know that I myself have behaved as though truly inanimate machines like car park charging meters etc could be reasoned with, thanked etc. A knowing whimsy. But maybe applying theory of mindset that way creates a vulnerability to these machines that more plausibly seem to be thinking. 010
Matthew Russell @matteomics.bsky.social · 12/09/2026Unit geekary is definitely my favourite kind of geekary. 071
Reposted by Matthew RussellJoe Bak-Coleman @jbakcoleman.bsky.social · 11/09/2026I stand firmly by my assertion that metascientists should have seen this capture of science coming, but there is no reasonable way they can reasonably delude themselves into thinking the new nsf announcements are anything other than epistemic capture. www.science.org/content/arti...science.orgScience’s reform movement should have seen Trump’s call for ‘gold standard science’ coming, critics sayEfforts to improve the rigor of research may have unwittingly handed the administration a way to attack science 29038
Matthew Russell @matteomics.bsky.social · 09/09/2026This is the important idea. Much thought, especially scientific, doesn't happen in language. It's expressed and communicated in language later. LLM can summarise and recompose that expression, but not think it, or think more of it. 000
Matthew Russell @matteomics.bsky.social · 07/09/2026Brian Deer was the UK journalist who covered / uncovered Wakefield back in the innocent 00's. Has a load of his articles on his website here: briandeer.com/mmr/st-mmr-r... In case anyone wants to revisit.briandeer.comSome of Brian Deer’s reports – briandeer.com 021
Matthew Russell @matteomics.bsky.social · 07/09/2026This is an important take. Environmentalism as a generalisation of the principle that one shouldn't defecate in ones own bath water. 000
Matthew Russell @matteomics.bsky.social · 07/09/2026Oh yes. Hence the manipulation of the dates autism was suspected in the kids in the study, because the lawyers wanted close association between jab and autism, which was a key part of the research misconduct case. 2131
Matthew Russell @matteomics.bsky.social · 07/09/2026Yeah, it was to push for single jabs over the triple MMR right? Although anti-vax continue to cycle through single jab demands, demand ban for particular ingredients etc. I guess those positions are reasonable looking gateways to entice new followers. 000
Matthew Russell @matteomics.bsky.social · 07/09/2026Was in the UK through the Wakefield thing. It was bonkers. Alt-med got big and people like @bengoldacre.bsky.social did great work exposing it. Felt like the good guys won for a bit. Seems now that was just a skirmish. Did not see the for-profit grift / far-right politics link. Should have. 2282
Matthew Russell @matteomics.bsky.social · 06/09/2026If you'll allow bags as technically I'd say bags. Carry more than your hands will hold. For original human tool makers let you retain multiple tools, and invest time making them. Bags make it possible to be human. The Alps 'ice man' had a bag that would not look too out of place today. 010
Matthew Russell @matteomics.bsky.social · 06/09/2026But what it really did was write a python script using pre-existing python libraries and drawing on a repository of audio analysis python code. Then ran the python script on the given audio file. It's cool. But it's LLM python writing, not originally problem solving. 120
Matthew Russell @matteomics.bsky.social · 04/09/2026My Star Trek TOS fan theory is that the use of physical control panels in the sci-fi setting is due to a resent culture wide rejection of touch screens and GUI. Possibly following their own enshitification crisis. 190
Matthew Russell @matteomics.bsky.social · 02/09/2026Love this framework. Current Me is always furious with Past Me but pushing burdens onto Future Me. 030
Reposted by Matthew Russell🎃Hana🎃 @robonohana.bsky.social · 02/09/2026Reading a book before bed is such a dangerous activity. For example, last night: "I'll read a couple chapters." Suddenly it's 1:47 AM and I've negotiated with myself that being tired tomorrow is a problem for Future Me. Future Me is now furious at Past Me. #booksky 921013
Matthew Russell @matteomics.bsky.social · 01/09/2026In good faith. Look for details. The wall socket plates has neither docket holes nor switch. The light switch is silly. The room exits to the right make no sense. The items, especially electronics, on shelves/units in background make no sense. Then, cat does not behave like a cat, so... 120
Matthew Russell @matteomics.bsky.social · 31/08/2026We have a data processing PC named after her. 030
Matthew Russell @matteomics.bsky.social · 30/08/2026Also most papers in most fields most of the time are incremental advances. Real break throughs do occur and are recognised. Where are the actual examples of world changing discoveries coming back from peer review with "extraordinary claims etc" in the notes. 000
Matthew Russell @matteomics.bsky.social · 28/08/2026I once spend an entire afternoon puzzling over prevelence, incidence and lifetime risk. 000
Reposted by Matthew RussellMark Janello @markjanello.bsky.social · 23/08/2026You fuckers made me do it. The Racist Academicals Patter Song. 12879299
Matthew Russell @matteomics.bsky.social · 26/08/2026Great little thread. Statistics and experimental design and policy all perfectly covered. 010
Reposted by Matthew RussellJulia M. Rohrer @dingdingpeng.the100.ci · 25/08/2026“…as peer reviewers or question askers at conferences, we must accept that our pet issue is not more important than the other 10 issues and if the analyst has had a good go at handling a bunch of issues, we can’t just pile more and more issues on them to fix. It is impossible.” 2354
Matthew Russell @matteomics.bsky.social · 24/08/2026Seems to me the same people who obsess over IQ on a racist/eugenics basis, are also the most keen on the creation of artificial general intelligence as a super intelligent slave for themselves. 010
Reposted by Matthew RussellKatie Mack @astrokatie.com · 24/08/2026Sometimes society at large rejects certain ideas because they’ve been thoroughly shown to be wrong and also because they suck and the people who espouse them suck and when someone comes around arguing those ideas should be part of some edgy modern debate we can and should shun them and move on. 7166891359
Matthew Russell @matteomics.bsky.social · 21/08/2026When I switch to R, all those moments will be lost ... like numeric values coded as strings. 010
Matthew Russell @matteomics.bsky.social · 20/08/2026And Aquinas only meant specialists are more more adept in their own area of expertise than generalists. Not a comment on fanatics. 010
Matthew Russell @matteomics.bsky.social · 20/08/2026Hmm, the 95% CI on "never use AI" on the left drops to similar level exam score as right hand "use AI". It's possible former no / cheat homeworkers are now AI home workers, but final performance is the same. So low exam performers are constant over time, but now self select AI user label. 110
Reposted by Matthew Russellnoam @noamchompers.bsky.social · 11/08/2026sorry, you want me to *revise* and then *resubmit* this shit? dog, i sent it to you because i never wanted to see it again 547667
Reposted by Matthew Russelltj mahr 🤘 @tjmahr.com · 11/08/2026interesting how “correlation is not causation” shifted from a warning about spurious associations to something incurious people say to refute things 1226
Matthew Russell @matteomics.bsky.social · 06/08/2026It may be we agree really. Although RCTs are only one kind of experiment, obviously particularly important in vital fields of medicine, agriculture etc. 000
Matthew Russell @matteomics.bsky.social · 06/08/2026Also out of all possible variables in the world, mostly unrelated or correlated with each other, your mechanistic theory picks 2 and predicts their relationship, and that relationship is confirmed experimentally? That's positive evidence for the theory, and so the causal relationship. 110
Matthew Russell @matteomics.bsky.social · 06/08/2026If you have a mechanistic theory about the world that predicts x has causal influence on y (providing the theory wasn't concocted to explain a prior observed correlation between x and y). Then do experiment to check the correlation. If the correlation exists the theory has passed at least one test. 100
Matthew Russell @matteomics.bsky.social · 06/08/2026I think some of the puritanical "correlation is not causation" statements around the place are missing the whole structure of scientific method which provide the context the statistics are done in. 110
Matthew Russell @matteomics.bsky.social · 06/08/2026Then there's the middle situation. Where a theory posits causation, between treatment and outcome maybe, but subgroup analysis or similar produces so may comparisons that random chance of correlation swamps the results. 100
Matthew Russell @matteomics.bsky.social · 06/08/2026That's different from a massive scan of many variables to find correlated ones. Which is a legitimate exercise in feature discovery. But pairs of identified correlated variables should be treated with great caution re causation. 100
Matthew Russell @matteomics.bsky.social · 06/08/2026Having a theory that predicts an as yet undetermined causal relationship between x and y, informing an experiment which finds a correlation between x and y, does add evidence for the correctness of the theory. 120