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Matthew Russell

@matteomics.bsky.social
228 followers 500 following 323 posts

Measurements want to be accurate; Experiments want to be elegant; Data wants to be beautiful and Data wants to be free #proteomics #rstats

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Reposted by Matthew Russell
Hadas Weiss @hadas.bsky.social · 07/10/2026
sure, sex is great but
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Matthew Russell @matteomics.bsky.social · 02/10/2026
My day feels very much like this! Although I only have a cold, Darwin was dealing with worse.
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Matthew Russell @matteomics.bsky.social · 28/09/2026
Sometime the real potential benefit of "reproducibility" is really auditability. The possibility of laying out the data and the steps for critical appraisal. The reproducibility makes that audit possible, it is not a magic test on its own.
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Colette Delawalla, PhD @cdelawalla.bsky.social · 28/09/2026
The humanities have been calling out genAI theft since the jump, while STEM has rallied around “discovery potential”. I am *ONCE AGAIN* reminding EVERYONE that science is not the sacred cow, STEM isn’t the exception. They are going to steal our IP, too. We aren’t special.
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Matthew Russell @matteomics.bsky.social · 28/09/2026
I think LLM finding and linking up research a single individual might never consider together, which maybe is what these stories really are, might actually support academic idea generation. But that use case can't justify or repay the trillions invested.
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Matthew Russell @matteomics.bsky.social · 24/09/2026
Really makes the case that various grades of #masspec based #proteomics could be useful at different points in #biotechnology development and processing monitoring. The next paper will show what I think is a really cool example.
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Matthew Russell @matteomics.bsky.social · 24/09/2026
So paper published! From Discovery Proteomics to Process-Informed Monitoring in Biomanufacturing Chassis Development pubs.acs.org/amachv/artic...
pubs.acs.org
From Discovery Proteomics to Process-Informed Monitoring in Biomanufacturing Chassis Development
Abstract. Gaining control of existing biomanufacturing chassis organisms, such as Escherichia coli K12, and novel isolates, such as the salt-tolerant Halom
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Matthew Russell @matteomics.bsky.social · 23/09/2026
The first one has strong Diana and Actaeon vibes. Actaeon is turned by the Goddess of the hunt into a dear who is brought down by his own hounds. en.wikipedia.org/wiki/Diana_a...
en.wikipedia.org
Diana and Actaeon - Wikipedia
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Matthew Russell @matteomics.bsky.social · 21/09/2026
The UK BBC has a talk radio channel called Radio 4 very middle aged middle class. It has a feedback programme where people who blatantly have R4 on as a constant background in their lives write in to complain about it. Similar phenomena I think.
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Matthew Russell @matteomics.bsky.social · 14/09/2026
What does it say about me that my first thought was "deep fry"
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Matthew Russell @matteomics.bsky.social · 14/09/2026
This is surely the same guy who ends up with Sarena Williams serving a ball cleanly through his skull when he thinks he can win a point from her. Great writing btw.
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Matthew Russell @matteomics.bsky.social · 12/09/2026
I know that I myself have behaved as though truly inanimate machines like car park charging meters etc could be reasoned with, thanked etc. A knowing whimsy. But maybe applying theory of mindset that way creates a vulnerability to these machines that more plausibly seem to be thinking.
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Matthew Russell @matteomics.bsky.social · 12/09/2026
Unit geekary is definitely my favourite kind of geekary.
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Reposted by Matthew Russell
Joe Bak-Coleman @jbakcoleman.bsky.social · 11/09/2026
I stand firmly by my assertion that metascientists should have seen this capture of science coming, but there is no reasonable way they can reasonably delude themselves into thinking the new nsf announcements are anything other than epistemic capture. www.science.org/content/arti...
science.org
Science’s reform movement should have seen Trump’s call for ‘gold standard science’ coming, critics say
Efforts to improve the rigor of research may have unwittingly handed the administration a way to attack science
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Matthew Russell @matteomics.bsky.social · 09/09/2026
This is the important idea. Much thought, especially scientific, doesn't happen in language. It's expressed and communicated in language later. LLM can summarise and recompose that expression, but not think it, or think more of it.
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Matthew Russell @matteomics.bsky.social · 07/09/2026
Brian Deer was the UK journalist who covered / uncovered Wakefield back in the innocent 00's. Has a load of his articles on his website here: briandeer.com/mmr/st-mmr-r... In case anyone wants to revisit.
briandeer.com
Some of Brian Deer’s reports – briandeer.com
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Matthew Russell @matteomics.bsky.social · 07/09/2026
This is an important take. Environmentalism as a generalisation of the principle that one shouldn't defecate in ones own bath water.
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Matthew Russell @matteomics.bsky.social · 07/09/2026
Oh yes. Hence the manipulation of the dates autism was suspected in the kids in the study, because the lawyers wanted close association between jab and autism, which was a key part of the research misconduct case.
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Matthew Russell @matteomics.bsky.social · 07/09/2026
Yeah, it was to push for single jabs over the triple MMR right? Although anti-vax continue to cycle through single jab demands, demand ban for particular ingredients etc. I guess those positions are reasonable looking gateways to entice new followers.
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Matthew Russell @matteomics.bsky.social · 07/09/2026
Was in the UK through the Wakefield thing. It was bonkers. Alt-med got big and people like @bengoldacre.bsky.social did great work exposing it. Felt like the good guys won for a bit. Seems now that was just a skirmish. Did not see the for-profit grift / far-right politics link. Should have.
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Matthew Russell @matteomics.bsky.social · 06/09/2026
If you'll allow bags as technically I'd say bags. Carry more than your hands will hold. For original human tool makers let you retain multiple tools, and invest time making them. Bags make it possible to be human. The Alps 'ice man' had a bag that would not look too out of place today.
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Matthew Russell @matteomics.bsky.social · 06/09/2026
But what it really did was write a python script using pre-existing python libraries and drawing on a repository of audio analysis python code. Then ran the python script on the given audio file. It's cool. But it's LLM python writing, not originally problem solving.
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Matthew Russell @matteomics.bsky.social · 04/09/2026
My Star Trek TOS fan theory is that the use of physical control panels in the sci-fi setting is due to a resent culture wide rejection of touch screens and GUI. Possibly following their own enshitification crisis.
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Matthew Russell @matteomics.bsky.social · 02/09/2026
Love this framework. Current Me is always furious with Past Me but pushing burdens onto Future Me.
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Reposted by Matthew Russell
🎃Hana🎃 @robonohana.bsky.social · 02/09/2026
Reading a book before bed is such a dangerous activity. For example, last night: "I'll read a couple chapters." Suddenly it's 1:47 AM and I've negotiated with myself that being tired tomorrow is a problem for Future Me. Future Me is now furious at Past Me. #booksky
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Matthew Russell @matteomics.bsky.social · 01/09/2026
In good faith. Look for details. The wall socket plates has neither docket holes nor switch. The light switch is silly. The room exits to the right make no sense. The items, especially electronics, on shelves/units in background make no sense. Then, cat does not behave like a cat, so...
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Matthew Russell @matteomics.bsky.social · 31/08/2026
We have a data processing PC named after her.
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Matthew Russell @matteomics.bsky.social · 30/08/2026
Also most papers in most fields most of the time are incremental advances. Real break throughs do occur and are recognised. Where are the actual examples of world changing discoveries coming back from peer review with "extraordinary claims etc" in the notes.
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Matthew Russell @matteomics.bsky.social · 29/08/2026
Me too.
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Matthew Russell @matteomics.bsky.social · 28/08/2026
I once spend an entire afternoon puzzling over prevelence, incidence and lifetime risk.
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Reposted by Matthew Russell
Mark Janello @markjanello.bsky.social · 23/08/2026
You fuckers made me do it. The Racist Academicals Patter Song.
[RACIST ACADEMICAL]
I am the very model of a racist academical,
With footnotes and citations to make bigotry seem credible,

I traffic in ideas that have long since been discredited,
Like human races being real and IQ is inherited!

I’ll sign an open letter that legitimates my bigotry,
My gender ideology is thuggery and piggery,

If criticized it’s academic freedom I will hide behind,
My high and mighty principles shan’t be questioned by your tiny mind!

[CHORUS OF CHUDS]
His high and mighty principles shan’t be questioned by your tiny mind!
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Matthew Russell @matteomics.bsky.social · 26/08/2026
Great little thread. Statistics and experimental design and policy all perfectly covered.
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Julia M. Rohrer @dingdingpeng.the100.ci · 25/08/2026
“…as peer reviewers or question askers at conferences, we must accept that our pet issue is not more important than the other 10 issues and if the analyst has had a good go at handling a bunch of issues, we can’t just pile more and more issues on them to fix. It is impossible.”
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Matthew Russell @matteomics.bsky.social · 24/08/2026
@rebeccasear.bsky.social Nails it here.
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Matthew Russell @matteomics.bsky.social · 24/08/2026
Seems to me the same people who obsess over IQ on a racist/eugenics basis, are also the most keen on the creation of artificial general intelligence as a super intelligent slave for themselves.
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Katie Mack @astrokatie.com · 24/08/2026
Sometimes society at large rejects certain ideas because they’ve been thoroughly shown to be wrong and also because they suck and the people who espouse them suck and when someone comes around arguing those ideas should be part of some edgy modern debate we can and should shun them and move on.
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Matthew Russell @matteomics.bsky.social · 21/08/2026
When I switch to R, all those moments will be lost ... like numeric values coded as strings.
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Matthew Russell @matteomics.bsky.social · 20/08/2026
And Aquinas only meant specialists are more more adept in their own area of expertise than generalists. Not a comment on fanatics.
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Matthew Russell @matteomics.bsky.social · 20/08/2026
Hmm, the 95% CI on "never use AI" on the left drops to similar level exam score as right hand "use AI". It's possible former no / cheat homeworkers are now AI home workers, but final performance is the same. So low exam performers are constant over time, but now self select AI user label.
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noam @noamchompers.bsky.social · 11/08/2026
sorry, you want me to *revise* and then *resubmit* this shit? dog, i sent it to you because i never wanted to see it again
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tj mahr 🤘 @tjmahr.com · 11/08/2026
interesting how “correlation is not causation” shifted from a warning about spurious associations to something incurious people say to refute things
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Christophe 🔬 Leterrier @christlet.bsky.social · 11/08/2026
Fixed it
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Matthew Russell @matteomics.bsky.social · 10/08/2026
Sounds like an excellent system.
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Matthew Russell @matteomics.bsky.social · 06/08/2026
It may be we agree really. Although RCTs are only one kind of experiment, obviously particularly important in vital fields of medicine, agriculture etc.
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Matthew Russell @matteomics.bsky.social · 06/08/2026
Also out of all possible variables in the world, mostly unrelated or correlated with each other, your mechanistic theory picks 2 and predicts their relationship, and that relationship is confirmed experimentally? That's positive evidence for the theory, and so the causal relationship.
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Matthew Russell @matteomics.bsky.social · 06/08/2026
If you have a mechanistic theory about the world that predicts x has causal influence on y (providing the theory wasn't concocted to explain a prior observed correlation between x and y). Then do experiment to check the correlation. If the correlation exists the theory has passed at least one test.
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Matthew Russell @matteomics.bsky.social · 06/08/2026
I think some of the puritanical "correlation is not causation" statements around the place are missing the whole structure of scientific method which provide the context the statistics are done in.
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Matthew Russell @matteomics.bsky.social · 06/08/2026
Then there's the middle situation. Where a theory posits causation, between treatment and outcome maybe, but subgroup analysis or similar produces so may comparisons that random chance of correlation swamps the results.
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Matthew Russell @matteomics.bsky.social · 06/08/2026
That's different from a massive scan of many variables to find correlated ones. Which is a legitimate exercise in feature discovery. But pairs of identified correlated variables should be treated with great caution re causation.
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Matthew Russell @matteomics.bsky.social · 06/08/2026
Having a theory that predicts an as yet undetermined causal relationship between x and y, informing an experiment which finds a correlation between x and y, does add evidence for the correctness of the theory.
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