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Matthew Burke

@mattburkemd.bsky.social
179 followers 55 following 18 posts

Cognitive Neurologist specializing in Neuropsychiatry at Sunnybrook Health Sciences Centre and the University of Toronto

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Reposted by Matthew Burke
Livia Asan @liviaasan.bsky.social · 11/05/2026
These two papers in Lancet Psychiatry about placebo/nocebo in practice and in trials are very worth reading. Be mindful about expectation in your patients/yourself, and critical even with RCTs. I hope reporting on placebo conditions, treatment expectations and blinding success improves steadily!!
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Tim Nicholson @timnicholson.bsky.social · 16/04/2026
Second article focuses on the critical issue of detecting/measuring & appraising placebo in trials Such a massively important (and complex/fascinating) issue in evidence based medicine that’s still so poorly understood www.sciencedirect.com/science/arti...
sciencedirect.com
Measuring and appraising placebo effects in clinical trials: contemporary challenges and approaches in psychiatry
Placebo effects are among the greatest paradoxes in medical research. Although more data on placebos are available from placebo-controlled trials than…
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Tim Nicholson @timnicholson.bsky.social · 16/04/2026
…and there’s this nice accompanying editorial on the 2 papers 👌 Bravo @mattburkemd.bsky.social 👏👏💪🏻💪🏻👌👌 www.sciencedirect.com/science/arti... @liviaasan.bsky.social @popkirov.bsky.social @susannahpick.bsky.social @davidlewisperez.bsky.social @jonstoneneuro.bsky.social
sciencedirect.com
Putting placebo effects in a new light
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Tim Nicholson @timnicholson.bsky.social · 16/04/2026
First of 2 great @thelancetpsych.bsky.social articles on placebo/nocebo in psychiatry (& relevance to all of medicine) led by the brilliant @mattburkemd.bsky.social This one on harnessing placebo & mitigating nocebo www.sciencedirect.com/science/arti...
sciencedirect.com
Harnessing placebo effects and mitigating nocebo effects: implications for clinical practice in psychiatry and medicine
In psychiatry and medicine, there is a long history of framing placebo effects primarily as nuisance factors and focusing on how they should be minimi…
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Matthew Burke @mattburkemd.bsky.social · 14/11/2025
Everyone is getting a diagnosis of ADHD these days Feature in @the-independent.com on our recent trial @uoftmedicine.bsky.social suggesting that nocebo effects (negative expectations) re ⬆️ awareness could be driving this trend. Nocebo education reversed it! www.the-independent.com/news/uk/home...
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Canadian Concussion Network-Réseau Canadien des Commotions @ccn-rcc.bsky.social · 18/09/2025
Rowan’s Law Day Clinical Update on Sport Concussion: Free webinar on September 24th at 12:00pm ET. 🔗: us02web.zoom.us/webinar/regi... @sunnybrookhsc.bsky.social @parachute.ca @mattburkemd.bsky.social
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Michael Inzlicht @minzlicht.bsky.social · 26/05/2025
🚨 New preprint! 🚨 Inform and Do No Harm: A Novel Approach to Reduce Negative Effects of Mental Health Awareness My student Dasha Sandra tackled growing concerns about false self-diagnosis following awareness efforts and found a promising solution. Thread /1 osf.io/preprints/ps...
osf.io
OSF
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Coping with Neurological Symptoms Lab @silverberglab.bsky.social · 21/05/2025
New paper with @mattburkemd.bsky.social, @davidlewisperez.bsky.social: Somatic Symptom Disorder after concussion/mTBI was associated with worse symptoms, comorbidity, and disability. SSD may be a useful framework for conceptualizing poor outcome from this injury. journals.lww.com/headtraumare...
journals.lww.com
Somatic Symptom Disorder After Mild Traumatic Brain Injury : The Journal of Head Trauma Rehabilitation
care centers. Participants: Adults with mTBI (N = 476). Design: Secondary analysis of a clinical trial (Clinicaltrials.gov NCT04704037). Main Measures: Early illness beliefs (Illness Percepti...
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David L Perez MD, MMSc @davidlewisperez.bsky.social · 10/05/2025
Outstanding #BrainMedicine conference led by #SaraMitchell & #SarahLevitt from the University of Toronto! Great to see momentum growing to erode silos & integrate neurologic, psychiatric, & rehabilitative perspectives for complex brain disorders. #SarahLidstone @mattburkemd.bsky.social
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Matthew Burke @mattburkemd.bsky.social · 07/04/2025
Very honoured to receive the 2025 AAN Norman Geschwind Prize for my research trying to better understand disorders and phenomena at the interfaces of Neurology and Psychiatry Very grateful to all my mentors and colleagues @sunnybrookhsc.bsky.social @uoftmedicine.bsky.social @harvardmed.bsky.social
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David L Perez MD, MMSc @davidlewisperez.bsky.social · 06/04/2025
Standing room only for 2 hour symposium on functional neurological disorder (#FND) at the #AAN2025 meeting - with a focus on functional seizures, post concussive syndrome / functional cognitive disorder & pathophysiology. #BarbaraDworetzky @mattburkemd.bsky.social
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Andreas Horn @andreashorn.org · 15/03/2025
Great intro to a promising session here at #nans2025 by @mattburkemd.bsky.social - do you know all the famous 🇨🇦 neuroscientists - Penfield, Milner, Hebb, Jasper and many more
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Matthew Burke @mattburkemd.bsky.social · 12/03/2025
Could having a TBI ever be paradoxically beneficial? We report a case of a patient with chronic refractory alcohol use disorder that went into remission following a TBI with a focal OFC hemorrhage 1/2 @commsmed.bsky.social @foxmdphd.bsky.social www.nature.com/articles/s43...
nature.com
Remission of alcohol use disorder following traumatic brain injury with focal orbitofrontal cortex hemorrhage: case report and network mapping - Communications Medicine
Haque et al. report a case of chronic alcohol use disorder that had early remission following a traumatic brain injury with left orbitofrontal cortex intracerebral hemorrhage. Mapping of this lesion c...
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Alan Carson @alancarson15.bsky.social · 02/03/2025
neurologyopen.bmj.com/content/7/1/... Very pleased to see this diagnostic aid for Functional cognitive disorders out. It needs further testing but i m feeling optimistic given the cumulative wisdom of the clinicians who kindly provided input into the development
neurologyopen.bmj.com
Development of a diagnostic checklist to identify functional cognitive disorder versus other neurocognitive disorders
Background Functional cognitive disorder (FCD) poses a diagnostic challenge due to its resemblance to other neurocognitive disorders and limited biomarker accuracy. We aimed to develop a new diagnosti...
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Matthew Burke @mattburkemd.bsky.social · 03/01/2025
Our new review looks at the evidence (or lack thereof) for identifying mTBI/concussion in post-acute polytrauma settings Challenges re: legitimately missing a mTBI (distracting injuries) with risk of overDx as Sx (e.g. headache, brain fog etc) are non-specific www.tandfonline.com/eprint/I7PSG...
tandfonline.com
Identifying mild traumatic brain injury in the post-acute polytrauma setting: a scoping review of diagnostic approaches and screening tools
Mild traumatic brain injury (mTBI) is frequently overlooked in polytrauma patients due to the overshadowing of more severe injuries, a fact that makes its identification in post-acute settings chal...
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Matthew Burke @mattburkemd.bsky.social · 17/12/2024
Unbeknownst to me, my patient wrote about her struggles and recovery from a head injury triggering FND Great to see a full page spread in @theglobeandmail.com on a topic that needs more attention Her eloquent narrative is a perfect (and timely) complement to our recent BJSM piece. Article ⬇️
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Jon Stone @jonstoneneuro.bsky.social · 12/12/2024
How common is FND? ‘Incidence and Prevalence of Functional Neurological Disorder: A systematic review’ – a new open access article in JNNP led by Sara Finkelstein with Clare Diamond, and @alancarson15.bsky.social jnnp.bmj.com/content/earl... 1/🧵
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Matthew Burke @mattburkemd.bsky.social · 10/12/2024
New to #bluesky and excited to share a new publication at the interface of my two main clinical interests in neuropsychiatry. "New Framework for the Continuum of Concussion and Functional Neurological Disorder" with @silverberglab.bsky.social in BJSM. Thread below 🧵 bjsm.bmj.com/content/earl...
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