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Mattias Malaguti

@matt-mala.bsky.social
155 followers 262 following 9 posts

Lecturer in Engineering Biology @edinburgh-uni.bsky.social Interested in understanding and engineering cellular neighbourhoods, and coming up with funky acronyms for new synthetic biology tools.

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Mattias Malaguti @matt-mala.bsky.social · 02/09/2026
Our lab's claim to fame: DNessie was featured by @plasmidsaurus.bsky.social Artwork by the multi-talented Eva Gonzalez Suarez and Mash Bandouil!
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Reposted by Mattias Malaguti
Alex Eve @amjeve.uk · 18/06/2026
Journal impact factors were released yesterday. In our latest @dev-journal.bsky.social Editorial, @jamesbriscoe.bsky.social and I discuss how we are all architects of impact, highlighting that measuring the influence and support journals provide goes beyond a single number. doi.org/10.1242/dev....
doi.org
The elephant in the room: impact factor
Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...
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Reposted by Mattias Malaguti
Michalis Averof @michalis-averof.bsky.social · 19/04/2026
Finding molecular tags that localise fluorescent proteins to the cell membrane was the goal of our latest paper, now published in Development @dev-journal.bsky.social. The tags act as address labels, sending proteins to the cell membrane, where they highlight the shape and arrangement of cells. 2/9
journals.biologists.com
Targeting the cell membrane in established and emerging model organisms
Summary: Screening a toolkit of diverse membrane-localising tags identifies candidates that efficiently localise proteins to the plasma membrane in a wide range of animals and choanoflagellates.
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Reposted by Mattias Malaguti
Naomi Moris @nmoris.bsky.social · 20/04/2026
I am giving a "Crash Course in Embryo Development" for the general public (no science background needed! pitched around GCSE-level) in London on 21st May www.crick.ac.uk/whats-on/cri... We'll dip into development, with a splash of embryo models, and a pinch of ethics. And it's free! Book online 👍
crick.ac.uk
Crick Crash Course: Embryo development
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Sally Lowell @cellysally.bsky.social · 31/03/2026
The ABC of my fave things in this paper: * ABOLISHING both silencing AND leakiness of SynNotch (check out the DTA-based demo of this 😍) while preserving high efficiency, in pluripotent & differentiating cells * BOOSTING signal during #PUFFFIN neighbour-labelling * CITING Robbie Burns (1786) 🏴󠁧󠁢󠁳󠁣󠁴󠁿
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Mattias Malaguti @matt-mala.bsky.social · 24/03/2026
Delighted to introduce KELPE: mESCs with two insulated genomic landing pads, which we use to generate new synNotch and PUFFFIN neighbour-labelling lines. They were named after kelpies, creatures from Scottish folklore, and they look pretty on a kelpie micropattern! #DevBio #SynBio
KELPE cells plated on micropatterned extracellular matrix forcing them to arrange in the shape of a kelpie.
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Chris Ponting @cgatist.bsky.social · 13/05/2025
Want to tell us about your challenges in interdisciplinary research within bioinformatics & biomedicine? Please take our HxC survey! Our aim is to create lasting change and address barriers to interdisciplinary collaboration and creativity app.onlinesurveys.jisc.ac.uk/s/edinburgh/... Thank you
app.onlinesurveys.jisc.ac.uk
HxC Survey on Interdisciplinary Work
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Mattias Malaguti @matt-mala.bsky.social · 09/04/2025
Extremely thankful to @acmedsci.bsky.social for the opportunity, and very excited to get started on this project at @edinburgh-uni.bsky.social ! #Springboard25
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Academy of Medical Sciences @acmedsci.bsky.social · 08/04/2025
🚨 Just 2 weeks left to apply for our Policy Internship with the Medical Research Council. Gain hands-on experience in science policy, insight into research impact and connect with top UK health leaders 🌟 Open to 3rd and 4th year MRC funded PhD students. 👉 Learn more and apply: lnkd.in/eNrYvPMh
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The Company of Biologists @biologists.bsky.social · 08/04/2025
We are highlighting Kate Storey, who served as a Director at @biologists.bsky.social from 2007 to 2022 and co-founded the Company’s Workshop programme, as an extraordinary biologist. #100biologists
The Company of Biologists 100 logo to the left and QR code to the right.
 
Portrait of Kate Storey to the left, text to the right
 
100 extraordinary biologists

Kate Storey

Kate Storey served as a Director from 2007 to 2022. She initiated the Company's Workshops programme and co-organised the first Workshop. Kate also co-initiated the Company's support for Sustainable Conferencing. Kate's lab researches nervous system development at the University of Dundee, UK.

#100biologists #biologists100
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Aida Rodrigo @aidarodrigo.bsky.social · 28/03/2025
Interested in biological research beyond the standard? Join us in Edinburgh for the EMBO Workshop exploring how unconventional vertebrate models are becoming engines for biomedical research! 🦇 🐿️ 🦌 🐒 🦍 🐹🧍‍♀️ 🚨 Abstract submission deadline: 11 April 2025 🚨 meetings.embo.org/event/25-ver...
meetings.embo.org
Beyond the standard: Unconventional vertebrate models in biomedicine
The use of a handful of model organisms has proven essential for scientific discovery and to unlock new therapeutics to combat human disease. As society looks to the future, the gateway to new scient…
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Development @dev-journal.bsky.social · 08/04/2025
In this Review, @bernasozen.bsky.social, Patrick Tam & Martin Pera summarize how recent studies of embryo models have advanced our understanding of cell state transitions of the pluripotent human epiblast and highlights some key remaining questions: doi.org/10.1242/dev....
Figure 2 Overview of cell state transitions in hPSCs in 2D and 3D embryo models. Embryo illustrations on the left represent the in vivo developmental stages corresponding to the three pluripotency states: naive (yellow), formative/intermediate (light green) and primed (dark green). On the right, the lineages they have the potential to give rise to in stem cell-based embryo models are illustrated. The generation of primordial germ cells (PGCs) from amnion remains to be determined. EXM, extra-embryonic mesoderm; PGCs, primordial germ cells.
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Takuya Azami @tazami.bsky.social · 07/04/2025
Happy to share our study on Stat3, now published in Cell Reports! Huge thanks to all collaborators! www.cell.com/cell-reports...
cell.com
STAT3 signaling enhances tissue expansion during postimplantation mouse development
Azami et al. reveal that STAT3 deletion depletes epiblast cells at implantation, causing a persistent developmental delay of around a day. STAT3 null embryonic stem cells contribute to all embryonic t...
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Mattias Malaguti @matt-mala.bsky.social · 07/04/2025
Best FACS plot I've ever seen!
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Developmental Biology @devbiol.bsky.social · 04/04/2025
Social Media Volunteers Needed! Developmental Biology is building a social media team (Bluesky X LinkedIn Insta )😎 If you're a passionate developmental biologist & interested in working with other social media enthusiasts for DB, apply today!😆 Deadline Apr 30 docs.google.com/document/d/1...
Developmental Biology is building a social media team! Apply before April 30th!
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Stem Cell Summer School @stemcellsummer.bsky.social · 07/04/2025
The 2025 European Summer School in Stem Cell Biology and Regenerative Medicine will take place 12-19 Sept 2025, on the beautiful Greek island of Spetses. Keep an eye on our website www.stemcellsummerschool.org for updates, or give us a follow 😀 Deadline for applications: 30th May 2025
Poster listing the faculty for the 2025 stem cell summer school on Spetses. Check our website (URL in bio) for full details.
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the Node @the-node.bsky.social · 07/04/2025
March in preprints In this latest monthly preprint list, we look back at the #DevBio and #StemCells #preprints that came out in March. (Let us know if we've missed anything!) thenode.biologists.com/march-in-pre...
thenode.biologists.com
March in preprints - the Node
Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv and arXiv –
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Mattias Malaguti @matt-mala.bsky.social · 07/04/2025
I'm over the moon for receiving an @acmedsci.bsky.social #Springboard25 award! We will use these funds to apply our synthetic neighbour-labelling tools to human skin organoids, to study communication between diseased cells and healthy neighbours. #EngBio #SynBio #DevBio #SkinResearch #CancerResearch
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Guillaume Jacquemet @guijacquemet.bsky.social · 07/04/2025
Here we share our opinions on "Practical considerations for data exploration in quantitative cell biology" journals.biologists.com/jcs/article/... Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful Many thanks to @jcellsci.bsky.social for publishing it
journals.biologists.com
Practical considerations for data exploration in quantitative cell biology
Summary: We present practical guidelines for data exploration in quantitative cell biology that are designed to help yield reliable conclusions and promote a collaborative, transparent approach to dat...
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Mattias Malaguti @matt-mala.bsky.social · 03/04/2025
Hello! My lab is interested in understanding how healthy mammalian cells sense and react to mutant neighbours. We do this by developing and using engineering biology tools to identify and manipulate neighbours of mutant cells. We also love taking colourful microscopy pictures!
A microscopy image of colourful cells
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