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Mathias V. Schmidt

@mathiasvschmidt.bsky.social
1.8K followers 446 following 70 posts

Unraveling the molecular basis of stress resilience | Group leader at MPI of Psychiatry | Secretary General Elect of FENS | Editor-in-Chief Neurobiology of Stress

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Reposted by Mathias V. Schmidt
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 16/09/2026
ALERT: Special Editorial focus issue on "Stress-induced impaired health and accelerated aging" Hosted by "Neurobiology of Stress" and "Neuroscience and Biobehavioral Reviews" co-edited with @mathiasvschmidt.bsky.social Details here: z.umn.edu/bkxb
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/07/2026
Check out the new website, grab the code, and let us know how DeepOF is supporting your research!
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/07/2026
📺 Watch the Step-by-Step Setup Guide on YouTube: www.youtube.com/watch?v=bz6c... Whether you are looking to scale up your behavioral screening, eliminate observer bias, or dive deep into the hidden structures of rodent behavior, DeepOF is built to streamline your workflow.
youtube.com
DeepOF (Set-up from scratch and Installation)
YouTube video by DeepOF
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/07/2026
𝘍𝘭𝘦𝘹𝘪𝘣𝘭𝘦 𝘌𝘯𝘷𝘪𝘳𝘰𝘯𝘮𝘦𝘯𝘵𝘴: Run it locally or straight out of the cloud using Google Colab. 🎥 Get Started in Minutes We have put together a comprehensive, step-by-step video guide that walks you through the entire installation, virtual environment setup, and running your first tutorial project:
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/07/2026
𝘚𝘦𝘢𝘮𝘭𝘦𝘴𝘴 𝘐𝘯𝘵𝘦𝘨𝘳𝘢𝘵𝘪𝘰𝘯: Works directly with all top-down recorded tests like OpenField, EPM, Fear Conditioning, Social Interaction, etc. 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘥 𝘚𝘱𝘢𝘵𝘪𝘢𝘭 𝘔𝘦𝘵𝘳𝘪𝘤𝘴: Automatically detect experimental arenas, define custom Regions of Interest (ROIs), and run complex downstream spatial-behavioral analyses.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/07/2026
🔍 What can you do with DeepOF? 𝘚𝘶𝘱𝘦𝘳𝘷𝘪𝘴𝘦𝘥 & 𝘜𝘯𝘴𝘶𝘱𝘦𝘳𝘷𝘪𝘴𝘦𝘥 𝘈𝘯𝘢𝘭𝘺𝘴𝘪𝘴: Detect pre-programmed behaviors (using built-in classifiers) or train machine learning models to discover entirely new, unbiased, unsupervised behavioral states.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/07/2026
𝐃𝐞𝐞𝐩𝐎𝐅 bridges this gap. Our open-source Python package offers an end-to-end pipeline for high-throughput, high-resolution deep phenotyping—fully accessible to the wider scientific community without requiring programming expertise.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/07/2026
What is 𝐃𝐞𝐞𝐩𝐎𝐅? Understanding animal behavior in high resolution is one of the greatest challenges in modern neuroscience. While deep learning tools have revolutionized pose estimation, translating the data into meaningful behavioral insights requires specialized setups and computational skills.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/07/2026
Launch of our brand-new website for 𝐃𝐞𝐞𝐩𝐎𝐅! 🚀 👉 Explore: deepof.ai
deepof.ai
DeepOF � Supervised and Unsupervised Behavioral Analysis
DeepOF: An open-source Python library for mouse behavioral analysis.
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Reposted by Mathias V. Schmidt
Mathias V. Schmidt @mathiasvschmidt.bsky.social · 30/06/2026
Stress and resilience researchers - check out this fantastic satellite event just before the start of the European College of Neuropsychopharmacology (ECNP) Meeting in Munich. We have a fantastic lineup of speakers. Registration (free) is now open: lnkd.in/gMsV4Ygc
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 30/06/2026
Stress and resilience researchers - check out this fantastic satellite event just before the start of the European College of Neuropsychopharmacology (ECNP) Meeting in Munich. We have a fantastic lineup of speakers. Registration (free) is now open: lnkd.in/gMsV4Ygc
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Reposted by Mathias V. Schmidt
Max Planck Institute of Psychiatry @mpi-psychiatry.bsky.social · 22/04/2026
Am 5. Mai gibt uns Biologe und Forschungsgruppenleiter @mathiasvschmidt.bsky.social einen Einblick in seine Forschung zum Thema Stress. Die Veranstaltung ist für alle offen, eine Anmeldung ist nicht nötig! Mehr Infos findet ihr hier: www.psych.mpg.de/mindmatters #biologie #stress #vortrag
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Reposted by Mathias V. Schmidt
Alessandro Bartolomucci Lab @bartolomuccilab.bsky.social · 21/04/2026
We are really thrilled to host this joint open special issue with among the two journals @mathiasvschmidt.bsky.social We are very interested to receive your best research at the intersection between stress, health and aging. Details here lnkd.in/dGfV24ex and in the linkedin post z.umn.edu/b971
linkedin.com
𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬: 𝐒𝐭𝐫𝐞𝐬𝐬 𝐚𝐧𝐝 𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞𝐝 𝐀𝐠𝐢𝐧𝐠 I am thrilled to announce a unique editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟… | PD Dr. Mathias V. Schmidt
𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬: 𝐒𝐭𝐫𝐞𝐬𝐬 𝐚𝐧𝐝 𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞𝐝 𝐀𝐠𝐢𝐧𝐠 I am thrilled to announce a unique editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐒𝐭𝐫𝐞𝐬𝐬 and 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐁𝐢𝐨𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐚𝐥 𝐑𝐞𝐯𝐢𝐞𝐰𝐬. Together ...
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20/04/2026
Detailed call for papers and submission guidelines here: www.sciencedirect.com/special-issu... We look forward to seeing your most innovative research! Please feel free to tag colleagues or share this post with your networks.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20/04/2026
𝐏𝐫𝐢𝐦𝐚𝐫𝐲 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡: Submit to Neurobiology of Stress (Select: “VSI: Stress and aging (YNSTR)”) 𝐑𝐞𝐯𝐢𝐞𝐰𝐬 & 𝐏𝐞𝐫𝐬𝐩𝐞𝐜𝐭𝐢𝐯𝐞𝐬: Submit to Neuroscience & Biobehavioral Reviews (Select: “VSI: Stress and aging (NBR)”)
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20/04/2026
We are seeking innovative work that pushes the boundaries of how we understand the long-term biological impact of stress. To ensure the best fit for your work, we have split the submission tracks:
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 20/04/2026
𝐍𝐞𝐰 𝐉𝐨𝐢𝐧𝐭 𝐂𝐚𝐥𝐥 𝐟𝐨𝐫 𝐏𝐚𝐩𝐞𝐫𝐬 I am thrilled to announce an editorial collaboration between 𝐍𝐞𝐮𝐫𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐒𝐭𝐫𝐞𝐬𝐬 and 𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐁𝐢𝐨𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐚𝐥 𝐑𝐞𝐯𝐢𝐞𝐰𝐬. With @bartolomuccilab.bsky.social, I am co-editing a virtual special issue focused on: 𝘚𝘵𝘳𝘦𝘴𝘴-𝘪𝘯𝘥𝘶𝘤𝘦𝘥 𝘪𝘮𝘱𝘢𝘪𝘳𝘦𝘥 𝘩𝘦𝘢𝘭𝘵𝘩 𝘢𝘯𝘥 𝘢𝘤𝘤𝘦𝘭𝘦𝘳𝘢𝘵𝘦𝘥 𝘢𝘨𝘪𝘯𝘨
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 24/03/2026
Thank you to our authors, reviewers, and readers for making 2025 an outstanding year. We invite you to read the full editorial and consider Neurobiology of Stress for your next submission! doi.org/10.1016/j.yn...
doi.org
Redirecting
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 24/03/2026
Looking back at the past year, the field of stress neurobiology has seen incredible growth. Our journal had the privilege of publishing groundbreaking work that pushes the boundaries of how we understand the bodies response to challenge and its impact to health and disease.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 24/03/2026
I am delighted to share our editorial for Neurobiology of Stress, co-authored with my fellow Editor-in-Chief, Lawrence Reagan doi.org/10.1016/j.yn...
doi.org
Redirecting
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 29/01/2026
Check out the full study here: doi.org/10.64898/202... Kudos to the fantastic team, especially lead author Sowmya Narayan and our incredible collaborators.
doi.org
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 29/01/2026
By combining advanced behavioral phenotyping with whole-brain c-Fos mapping, manganese-enhanced MRI, and transcriptomics in mouse models, we found that developmental stress often has opposite neurobiological effects in males vs. females.
doi.org
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 29/01/2026
I’m thrilled to share our latest preprint from the lab, now available on BioRxiv! We investigated how early life adversity (ELA) shapes the adult brain, and the results are a stark reminder that sex isn't just a variable but leads to fundamentally different stress-induced mechanistic consequences
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 10/11/2025
This is the path to robust, translational data. 𝐃𝐨𝐧'𝐭 𝐏𝐚𝐧𝐢𝐜! Read the full guide and join the shift to deep phenotyping. Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 10/11/2025
We provide: - A standardized workflow for long-term home-cage monitoring in mice. - A practical guidance on experimental setups for 24-hour recordings. - A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases .. and much more!
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 10/11/2025
Check out our new paper in Neuroscience & Biobehavioral Reviews: "𝑳𝒐𝒏𝒈-𝒕𝒆𝒓𝒎 𝒅𝒆𝒆𝒑 𝒑𝒉𝒆𝒏𝒐𝒕𝒚𝒑𝒊𝒏𝒈 𝒐𝒇 𝒃𝒆𝒉𝒂𝒗𝒊𝒐𝒓𝒂𝒍 𝒕𝒓𝒂𝒊𝒕𝒔 𝒊𝒏 𝒎𝒊𝒄𝒆 𝒖𝒔𝒊𝒏𝒈 𝒉𝒐𝒎𝒆𝒄𝒂𝒈𝒆 𝒎𝒐𝒏𝒊𝒕𝒐𝒓𝒊𝒏𝒈" This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...
sciencedirect.com
Long-term deep phenotyping of behavioral traits in mice using homecage monitoring
Neuropsychiatric disorders represent a significant global health challenge, and a deeper understanding of their underlying neurobiology is urgently ne…
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 10/11/2025
To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 03/11/2025
Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.
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Reposted by Mathias V. Schmidt
Federation of European Neuroscience Societies - FENS @fens.org · 16/10/2025
🚨Open position at #FENS! 💭Do you want to help strengthen the voice of #neuroscience? Apply for the Advocacy and Engagement Internship at FENS! 🗓️ The deadline for applications is 31 October! 👉 loom.ly/2Qy18y8
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 10/10/2025
Looking forward to this exciting conference. If you are interested in the latest science on the developmental origins of mental illness, join me and my co-chair @talliezee.bsky.social for our session on Sunday morning at 11:20am.
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Carmen Sandi @carmensandi10.bsky.social · 07/10/2025
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens. Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators! 🔗 Paper: doi.org/10.1016/j.bi...
doi.org
Redirecting
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Natalie Matosin @nataliematosin.bsky.social · 25/09/2025
Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in: www.biorxiv.org/content/10.1...
biorxiv.org
Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling
Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 21/08/2025
Important initiative 👇
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 30/06/2025
Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.
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Reposted by Mathias V. Schmidt
ebbsociety.bsky.social @ebbsociety.bsky.social · 28/06/2025
The heat won’t stop the energy — science (and fans!) in full swing! 🔆🪭💪 #EBBS2025
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 28/06/2025
In Bordeaux for the #EBBS meeting. Looking forward to 4 exciting days of science
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Natalie Matosin @nataliematosin.bsky.social · 10/06/2025
🚨 NEW PAPER 🚨 Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
sciencedirect.com
Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides
Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…
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EARA @eara.eu · 03/06/2025
The Be Open about Animal Research Day is starting now! Show your support and share on #BOARD25
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Reposted by Mathias V. Schmidt
Oliver Bosch @olibosch.bsky.social · 26/05/2025
🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here: www.neurobiologyofgrief.org/events
neurobiologyofgrief.org
Events — Neurobiology of Grief International Network
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 23/05/2025
Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
cell.com
The evolving neurobiology of early-life stress
This review explores the effects of early-life stress on brain development and cognitive function, highlighting gaps in understanding perceived stress, vulnerable developmental stages, underlying mole...
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Jamie Hanson @jamielarsh.bsky.social · 05/05/2025
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...
sciencedirect.com
Childhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry
Autoimmune diseases are a heterogeneous category of disorders caused by an interaction between genetic and environmental factors which lead to a dysre…
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 23/04/2025
Read about our recent discoveries on mechanisms that can drive resilience in females. www.psych.mpg.de/2949097/news...
psych.mpg.de
Early Life Stress Can Build Resilience in Females
Stress in early life can improve emotional regulation and cognitive function in female mice. This is a significant departure from the traditional view that such stress is solely detrimental. The study...
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 02/04/2025
So well deserved! Congratulations 👏🏻👏🏻👏🏻
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Camilla Bellone @bellonec.bsky.social · 24/03/2025
The Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now. #Neuroscience #BrainResearch www.sfn.org/careers/awar...
sfn.org
Peter Seeburg Integrative Neuroscience Prize
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Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 23/03/2025
Intergenerational Effects of Stress - A Focus on Learning and Memory doi.org/10.1007/7854...
doi.org
Intergenerational Effects of Stress – A Focus on Learning and Memory
Stress is a ubiquitous facet of life. Ranging in form (e.g., psychosocial, physical, nutritional, economic) and longevity (e.g., acute, chronic), stressors affect the biology of those directly in thei...
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Brian Trainor @briantrainor.bsky.social · 15/03/2025
We're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/
tiktok.com
lab but aesthetic 🤩 comment how a typical day looks for you #sza #dayinlife #interviews #science #lablife #labtech #behindthescene
TikTok video by trainor lab
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/03/2025
Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/03/2025
Our data especially highlight the importance of studying sex differences in how individuals cope with stress.
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Mathias V. Schmidt @mathiasvschmidt.bsky.social · 14/03/2025
New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
nature.com
FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice - Nature Communications
Early life stress can induce lasting changes in brain function and behavior. Here, authors show that glutamatergic FKBP51 specifically in females mediates adaptive stress effects on anxiety and cognit...
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Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · 10/03/2025
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis www.nature.com/articles/s41...
nature.com
Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis - Nature Communications
Early life experience modulates stress resilience in later life. Here the authors show that maternal care triggers microglia-derived IGF-1 levels, which suppresses the neuronal C/EBPβ-DRP1 axis, promo...
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