Exercise is increasingly recognized as a disease-modifying intervention in multiple sclerosis. A new study published in Nature Metabolism shows that the muscle-derived hormone irisin promotes neuronal...

Exercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral administration of irisin.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Beyond inflammation, progressive neurodegeneration is a major determinant of irreversible disability in p...