iiinova — where your digital self keeps evolving

Liz Tseng @magdoll.bsky.social · 21/07/2026

New to @pacbio.bsky.social HiFi data? Want to learn more about long-read #bioinformatics? Want to know how to read methylation tags in BAM files? This is the bootcamp for you! Sign up to get access to recorded tutorials + live Q&A session. programs.pacb.com/l/1652/2026-...

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PacBio @pacbio.bsky.social · 26/05/2026

SPRQ-Nx chemistry is now shipping worldwide, bringing sub-$300 HiFi genomes to the Revio platform! This global rollout cuts sequencing costs by 30%, making it easier than ever to scale high-throughput workflows Full press release here: bit.ly/49HwmcL #SPRQNx #PacBio #HiFisequencing #Revio

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PacBio @pacbio.bsky.social · 18/03/2026

PacBio is proud to partner with Basecamp Research to generate high-fidelity metagenomic data for the Trillion Gene Atlas, a landmark initiative to model biological data at the trillion-gene scale and accelerate AI-designed therapeutics. Learn more here: bit.ly/479RQh3 #PacBio #TrillionGeneAtlas

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Eric Topol @erictopol.bsky.social · 19/02/2026

Predicting when symptoms of Alzheimer's disease will occur with a single elevated p-tau217 blood test and a person's age, even 20+ years in advance @naturemedicine.bsky.social nature.com/articles/s41...

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Liz Tseng @magdoll.bsky.social · 24/11/2025

Subtle differences in repeat motifs can cause drastic diff in disease onset: using @pacbio.bsky.social PureTarget amp-free identifies non-canonical repeats and its ratio assoc. with disease onset for Spinocerebellar ataxia type 10 (SCA10) www.neurology.org/doi/full/10....

neurology.org

Novel ATXN10 Repeat Motif Patterns in Peruvian Families Modify Disease Onset | Neurology Genetics

ObjectivesSpinocerebellar ataxia type 10 (SCA10) is an autosomal-dominant disorder caused by intronic expansions of pentanucleotide repeats in the ATXN10 gene. While various repeat motifs have been de...

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Liz Tseng @magdoll.bsky.social · 10/11/2025

PangyPlot: a new #bioinformatics tools for visualizing pangenomes that supports linear coordinates and large graphs. Applied to @pacbio.bsky.social HiFi genomes to visualize two cystic fibrosis-relevant region not possible to resolve with short read genomes. www.biorxiv.org/content/10.1...

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Liz Tseng @magdoll.bsky.social · 06/11/2025

How does @pacbio.bsky.social long-read RNA-Seq help explain response difference through RNA splicing regulation in immunotherapy? Check out the Dec webinar with @olgaanczukow.bsky.social and Ryan Englander and I! www.the-scientist.com/long-read-rn...

the-scientist.com

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

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Liz Tseng @magdoll.bsky.social · 05/11/2025

New @pacbio.bsky.social #bioinformatics spotlight video is up! SQANTI-QC: a multi-sample long-read RNA-Seq QC tool! Demo included. Check it out and give it a try! www.youtube.com/watch?v=83XL...

youtube.com

Using SQANTI-reads for long-read RNA-Seq quality control

YouTube video by PacBio

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PacBio @pacbio.bsky.social · 05/11/2025

A new multi-center study from the EMEA HiFi Solves Consortium shows the clinical research potential of HiFi. Combined with our latest informatics pipeline, HiFi identified 100% of clinically relevant variants across 11 complex regions, including those short reads missed. 👉 bit.ly/4oqMWCY

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Liz Tseng @magdoll.bsky.social · 27/10/2025

Wonder how @pacbio.bsky.social long read sequencing is transforming how clinical and translational labs approach genomics? Hear from panelists from Myriad Genetics, GeneDx, Karolina and Radboudumc discuss rare disease testing, carrier screening, and more! programs.pacb.com/l/1652/2025-...

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Liz Tseng @magdoll.bsky.social · 23/10/2025

Want a rare look inside @pacbio.bsky.social facility and hear how customers use HiFi for HLA typing and PGx? We made a 6-min documentary this summer. Check it out! www.youtube.com/watch?si=nXb...

youtube.com

Advancing human health with HiFi long-read sequencing

YouTube video by PacBio

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Robert Aboukhalil @robert.bio · 09/10/2025

Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.

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Liz Tseng @magdoll.bsky.social · 09/10/2025

How does @pacbio.bsky.social long-read sequencing and AI interact to assess AAV genome integrity? Find out at this Catalent webinar on 10/29! event.on24.com/wcc/r/509468...

event.on24.com

Integrating DNA Sequencing and AI for AAV Genome Integrity

Wednesday, October 29, 2025 at 2:00 PM Eastern Daylight Time.

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PacBio @pacbio.bsky.social · 08/09/2025

The human #microbiome holds enormous potential, but only if we can see it clearly. Join this webinar to learn how #PacBio HiFi sequencing delivers accurate, high-resolution insights with 16S rRNA sequencing and shotgun metagenomics. Secure your spot: bit.ly/4mYmK1G

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Liz Tseng @magdoll.bsky.social · 20/08/2025

If DNA sequencing technologies had dating profiles 😜🧪

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Liz Tseng @magdoll.bsky.social · 19/08/2025

Learn from about @pacbio.bsky.social HiFi and then have a chance to WIN some!

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Liz Tseng @magdoll.bsky.social · 14/08/2025

Rarely do I get this excited about a @pacbio.bsky.social Iso-Seq study! 🧠 Come hear how the Tripathy lab used long-read multiomics to study neuron development—finding new isoforms suggesting some non-coding ASD variants may disrupt splicing & protein function. programs.pacb.com/l/1652/2025-...

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Liz Tseng @magdoll.bsky.social · 07/08/2025

Just released @pacbio.bsky.social Kinnex-10x GEM-X single cell data for both Revio and Vega! Go check out the updated app note and dataset URL! App note: www.pacb.com/wp-content/u... Dataset: downloads.pacbcloud.com/public/datas...

pacb.com

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PacBio @pacbio.bsky.social · 23/07/2025

#PacBio is contributing Iso-Seq data to the 1000 Genomes Long Read Sequencing Project using #Kinnex kits and the #Revio system. This data from 1,000 globally diverse samples will help advance transcript-level insights across populations. Press release here: bit.ly/4mdzHEe

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Liz Tseng @magdoll.bsky.social · 10/07/2025

A once-in-a-decade bloom of Chanel the corpse flower (Amorphophallus Titanum) at the San Francisco Conservatory of Flowers and I caught the very tail end of its 48 hour blooming span! 🌸🌸🌷🌷

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Liz Tseng @magdoll.bsky.social · 23/06/2025

Learn from the best @pacbio.bsky.social users on their tips and tricks! (fun fact: I interviewed Lutz but I'm behind the camera so you won't see me ;>)

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Eric Topol @erictopol.bsky.social · 22/06/2025

Spotlight on the gut-brain axis A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine erictopol.substack.com/p/the-gut-br...

erictopol.substack.com

The Gut-Brain Axis Takes Center Stage

A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine

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Liz Tseng @magdoll.bsky.social · 12/06/2025

Deepest long-read RNA-Seq dataset for one single cell line, multiple time points + replicates using @pacbio.bsky.social Kinnex RNA kit! Wissel et al. show that Kinnex can be used for isoform quantitative analyses: www.biorxiv.org/content/10.1...

biorxiv.org

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Liz Tseng @magdoll.bsky.social · 10/06/2025

Really loving this live demo of our @pacbio.bsky.social Vega benchtop sequencer by the one-and-only Sterling Maurer. Vega is so simple...probably I can do it (but I shouldn't XD) www.youtube.com/watch?v=wK90...

youtube.com

PacBio Vega: Benchtop HiFi Sequencer Demo (ASHG 2024)

YouTube video by PacBio

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Liz Tseng @magdoll.bsky.social · 05/06/2025

If you're in the San Francisco bay area and is a 10x single-cell/spatial user, @pacbio.bsky.social will be at the UCSF Gladstone 10x Symposium next week! I'll be there too! Come learn how to power up your 10x data with long reads! tinyurl.com/2mev7pj6

tinyurl.com

UCSF and Gladstone Institutes Single Cell and Spatial Discovery Symposium

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Liz Tseng @magdoll.bsky.social · 27/05/2025

Next week! Come learn how @pacbio.bsky.social HiFi enables IGH genotyping and near-full-length TCR/BCR sequencing for immunotherapy research! programs.pacb.com/l/1652/2025-...

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Jeremy Wilkinson @jewilki.bsky.social · 16/05/2025

So fantastic to see an all women panel at #PacBioPRISM today moderated by @magdoll.bsky.social. #HiFi #longreads @pacbio.bsky.social

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Liz Tseng @magdoll.bsky.social · 07/05/2025

@pacbio.bsky.social instrument lounge at PRISM San Francisco event today! Great talks this morning and now we’re moving into parallel workshops.

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PacBio @pacbio.bsky.social · 11/04/2025

🔍 Another blurry challenge is here! It's Find Your Focus Friday. Guess what's hidden in the image to earn an entry. Tag a friend for double the entries! With #PacBio, #TheresHiFiForThat — clear answers from the start. T&Cs: bit.ly/3O3AfhD

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Liz Tseng @magdoll.bsky.social · 21/03/2025

It's @pacbio.bsky.social fairy tale Friday! Once upon a time, you do lots of PCRs to screen different ataxia genes. Now with PureTarget, you can do 20 genes at once, get repeat lengths, repeat sequences, and even methylation patterns!

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Jeremy Wilkinson @jewilki.bsky.social · 19/03/2025

If you're looking for a way to streamline your #PacBio full-length 16S workflow or just wanting to try it out before investing in purchasing barcoded FL 16S primer stocks, check out the #ZymoResearch Quick-16S Full-Length Library Prep Kit to get started! #longread #microbiome

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Liz Tseng @magdoll.bsky.social · 19/03/2025

New Kinnex achievement unlocked! 194Gb with Revio SPRQ! Well deserved @udelaware.bsky.social

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Liz Tseng @magdoll.bsky.social · 11/03/2025

"Don't just focus on gene expressions". Instead, you might find common mis-splicing patterns that aren't derived from SF mutations, is associated with prognosis, and may have therapeutic potential. Intrigued? Register for @pacbio.bsky.social webinar next week! programs.pacb.com/l/1652/2025-...

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Liz Tseng @magdoll.bsky.social · 10/03/2025

Sunday cafe reading! I sort of “won” this book from a recent @pacbio.bsky.social internal event and I’m greatly enjoying it! So much to think about on pursuing greatness, offering hospitality, and relationship management.

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Eric Topol @erictopol.bsky.social · 09/03/2025

We've known about the gut-brain axis. Now we're learning about the gut-brain-lung axis whereby food intake can trigger an immune response in the airway. www.cell.com/neuron/fullt...

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Liz Tseng @magdoll.bsky.social · 04/03/2025

@pacbio.bsky.social Vega in the flesh today at Stanford!! 😁

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Liz Tseng @magdoll.bsky.social · 04/03/2025

@pacbio.bsky.social Vega benchtop demo + office hour this afternoon at Stanford! I'll be there! Come hang out with us and check out Vega :-)

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Liz Tseng @magdoll.bsky.social · 03/03/2025

Bay area folks! Want a chance to see the new @pacbio.bsky.social benchtop Vega in person? Chat with me and other PacBio folks about HiFi sequencing? We're hosting a Vega showcase + office hour tomorrow at Stanford! Come say hi! programs.pacb.com/l/1652/2025-...

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Liz Tseng @magdoll.bsky.social · 03/03/2025

Happy Monday! Let's start this week with fairy tales! ONCE UPON A TIME extracting high molecular weight (HMW) DNA was difficult. But now, with @pacbio.bsky.social Nanobind extraction kits. you get HMW DNA in, and beautiful long reads -> genome assemblies out! 💫⭐🧪🧬 www.pacb.com/products-and...

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Liz Tseng @magdoll.bsky.social · 28/02/2025

A coworker sent me this this morning and cracked me up so much! 🧬🧪 xkcd.com/3056/

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Eric Topol @erictopol.bsky.social · 28/02/2025

AIR-BORNE, @carlzimmer.com's new book, is an enthralling deep dive into airborne diseases. The colossal failure to recognize that #COVIDisAirborne is thoroughly reviewed. Our podcast erictopol.substack.com/p/carl-zimme... Open-access, with transcript and full video, + relevant links

erictopol.substack.com

Carl Zimmer: Air-Borne and the Big Miss With Covid

One of the top science journalists of our time discusses his new book

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Liz Tseng @magdoll.bsky.social · 27/02/2025

AAV/gene therapy folks! Join me, @formbio.bsky.social and others in North Carolina next month to discuss all things AAV - including how @pacbio.bsky.social long-read AAV sequencing can help characterize and improve AAV vector design! www.formbio.com/2025-aav-sum...

formbio.com

AAV Innovation Summit 2025

Join gene therapy professionals for a half-day summit on advancing AAV therapeutics through AI, genome integrity and vector design.

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PacBio @pacbio.bsky.social · 25/02/2025

Current AIRR-seq methods have limitations. At #AGBT25, Melissa Smith showcases how #PacBio highly accurate long reads provide the resolution needed to fully understand immune responses—paving the way for better immunotherapy and precision genomic medicine. #AGBTGM

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PacBio @pacbio.bsky.social · 25/02/2025

Genotype matters. At #AGBT25, Melissa Smith explores how germline-targeted immunogens and IGH variation impact immune response. Highly accurate #PacBio long reads help reveal critical insights for immunogenomics and precision medicine. #AGBTGM

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