Temporal profiling of central carbon metabolism during KrasG12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions.

Two studies published in Nature Metabolism show that dysregulation of specific metabolic enzymes within the pancreas leads to increased oxidative stress, which promotes pancreatic neoplasia in the pre...

In the early stages of pancreatic ductal adenocarcinoma (PDAC) development, loss of ALDH1L2 expression elevates reactive oxygen species levels, driving accelerated acinar-to-ductal metaplasia. Decreas...

Temporal profiling of central carbon metabolism during KrasG12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancero...

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The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

Red blood cells (RBCs) have a limited lifespan of approximately 120 days. This necessitates continuous RBC production, resulting in ∼200 billion new RBCs made per day to maintain oxygen delivery. Desp...

We’ve come too far to go back to a time when autism was defined solely in terms of deficits and mothers were made to feel guilty.

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

A team of researchers from Michigan Medicine tracked how glucose is used in glioblastoma tumor cells. They showed that dietary interventions can slow brain cancer growth in mice.

As the CDC reels from departures, White House appoints Jim O’Neill as acting director.