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L Brielmaier

@lynnbr2.bsky.social
265 followers 238 following 2.1K posts

Electronics Engineer who has ALS. Member IEEE Brain, EMBS,iBCI-CC.org. Designed & built a custom AI LLM capable AAC eye gaze computer. BCI candidate to drive my exoskeleton. Python noob. Interested in EAPs. #MedSky

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L Brielmaier @lynnbr2.bsky.social · 4h
Former NFL player Steve Gleason, a safety for the New Orleans Saints from 2000 to 2006, has turned to music after his amyotrophic lateral sclerosis diagnosis. (People) people.com/former-nfl-p...
people.com
Former NFL Player Steve Gleason Turns to Music with Empowering New Project During 15-Year Fight Against ALS
Former NFL player Steve Gleason is releasing a 12-song project that explores his love for football and fight with ALS called ‘REBIRTH’ on Oct.
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L Brielmaier @lynnbr2.bsky.social · 8h
simply outperforming animal models is necessary but not sufficient. The adoption of Non-Animal Models will require changes in policy, training, and culture. spectrum.ieee.org/alternatives...
spectrum.ieee.org
Can New Technologies Finally Replace Animal Testing?
Changing habits may be the hardest engineering challenge of all
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L Brielmaier @lynnbr2.bsky.social · 10h
Elder Index: Measuring the income older U.S. adults need to live independently elderindex.org/explore
elderindex.org
Measuring the income older adults need to live independently
The Elder Index is a measure of the income that older adults need to meet their basic needs and age in place with dignity. The Elder Index is specific to household size, location, housing tenure, and ...
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Reposted by L Brielmaier
Bridging Voice @bridgingvoice.bsky.social · 02/10/2026
It's AAC Awareness Month—the perfect time to reshare our "What is AAC?" guide! AAC (Augmentative & Alternative Communication) is the collection of tools and strategies that help you communicate when speaking or using hands becomes difficult. It's at the heart of everything we do at Bridging Voice.
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L Brielmaier @lynnbr2.bsky.social · 18h
some patients with non-small-cell lung cancer who have surgery & start a targeted drug early, Dr. Herbst said, oncologists like himself now even dare to mouth the word “cure.” 34 %of patients with non-small-cell lung cancer never got a genetic test of their tumors. www.nytimes.com/2026/09/30/s...
nytimes.com
New Cancer Drugs Are Revolutionary. Why Don’t More Patients Get Them? (Gift Article)
Targeted gene therapies are highly effective at stopping cancers, but the very abundance of the treatments, plus cost and sluggish change, are hindering access.
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L Brielmaier @lynnbr2.bsky.social · 01/10/2026
He should spend more time in the U.S. www.nytimes.com/2026/09/30/w...
nytimes.com
In Fractious France, Politicians Agree on One Thing: Pope Leo Was a Hit (Gift Article)
In a four-day visit, Pope Leo XIV won praise across the political spectrum, even from its most avowedly secular figures.
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L Brielmaier @lynnbr2.bsky.social · 01/10/2026
Unpopular Opinion : If Doctors can't participate in justified assisted suicide, they can't participate in justified executions. www.nytimes.com/2026/10/01/u...
nytimes.com
After Failed Attempt to Execute Christa Pike, Tennessee Pauses a Planned Execution (Gift Article)
Gov. Bill Lee, a Republican, ordered a review of the state’s lethal injection process after the botched attempt to put Christa Pike to death. She was hospitalized Wednesday.
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Chronic Illness Humor @chronicillness.bsky.social · 29/09/2026
meme featuring bold white text at the top and bottom over a photo of a young child sitting at a table, completely face down in exhaustion with their face resting directly on top of a sandwich on a white plate.

Top text: "I USED TO EAT TO REFUEL MY ENERGY"

Bottom text: "NEVER IMAGINED HAVING ILLNESS THAT MAKES ME FATIGUED FROM EATING"
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IEEE EMBS @embs.org · 30/09/2026
A new #IEEE TNSRE study shows how remaining muscle signals from people with cervical #SpinalCordInjury can reveal hand-movement intentions and control a robotic "sixth finger" for functional grasping tasks. ieeexplore.ieee.org/document/116838…
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IEEE Spectrum @spectrum.ieee.org · 30/09/2026
MED-EL’s new implant puts the microphone, processor, and battery entirely beneath the skin, enabling users to hear while sleeping, swimming, and exercising.
spectrum.ieee.org
World’s First Fully Implanted Cochlear Implant Reaches Patients
Users get round-the-clock hearing with no visible external hardware
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Reposted by L Brielmaier
Silverlark Media @silverlarkmedia.bsky.social · 30/09/2026
From my morning feed. 🙄
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L Brielmaier @lynnbr2.bsky.social · 30/09/2026
They provide free services via Bridging Voice to those with ALS! Founded in 2022, the company is known for generating ultra-realistic human voices and sound effects. www.msn.com/en-us/money/...
msn.com
MSN
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L Brielmaier @lynnbr2.bsky.social · 26/09/2026
“The more you can escape from how horrible things really are, the less it's going to bother you...and then, the worse things get.” ― Frank Zappa
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L Brielmaier @lynnbr2.bsky.social · 25/09/2026
On the Historic Results of the FUSION Trial for FUS-ALS. projectals.org/lori-hermsta... This is the second genetic ALS gene that has been reverse-engineered to create a functional therapy!
projectals.org
A Statement From Lori Hermstad: On the Historic Results of the FUSION Trial for FUS-ALS. | Project ALS
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Chronic Illness Humor @chronicillness.bsky.social · 24/09/2026
Vintage-style Gothic artwork featuring a woman in a long white nightgown fleeing past a gnarled, leafless tree under a dark, dramatic sky. White serif text centered at the top of the image reads: "Ask your doctor if running screaming into the savage night might be right for you." A small copyright watermark reading "©ephemera.com" is visible in the bottom right corner.
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L Brielmaier @lynnbr2.bsky.social · 24/09/2026
The diagnostic biomarker problem in amyotrophic lateral sclerosis: This Update distinguishes disease state biomarkers from diagnostic biomarkers; academic.oup.com/brain/advanc...
academic.oup.com
Validate User
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L Brielmaier @lynnbr2.bsky.social · 23/09/2026
It is unclear if the administration plans to revive the matter later through another directive. www.nytimes.com/2026/09/23/u...
nytimes.com
Trump Backtracks on Plan for New Controls on N.I.H. Grants (Gift Article)
Democrats and Republicans in Congress opposed the creation of a commission with the power to veto federal research awards.
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ALS Therapy Development Institute @alstdi.bsky.social · 21/09/2026
At the ALS TDI Summit, hear from ALS TDI scientists and guest experts about promising new approaches across the field—and learn how ALS TDI's expansion will increase our capacity to pursue more of these opportunities. Read our blog to learn more: www.als.net/news/attend-...
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L Brielmaier @lynnbr2.bsky.social · 22/09/2026
could explain why the eye muscles are the last to go in ALS?
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L Brielmaier @lynnbr2.bsky.social · 21/09/2026
Charging Patients Credit Card Processing Fees: What is Permissible and What is Prohibited Debit cards are different in the U.S. www.jdsupra.com/legalnews/ch...
jdsupra.com
Charging Patients Credit Card Processing Fees: What is Permissible and What is Prohibited | JD Supra
As credit card processing fees continue to rise, many healthcare providers are exploring whether they can pass those costs on to patients. The answer...
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L Brielmaier @lynnbr2.bsky.social · 21/09/2026
Scientists Created Mice With Half-Human Brains. The Hybrid Animals Could Revolutionize Our Understanding of Neurological Disorders www.smithsonianmag.com/smart-news/s...
smithsonianmag.com
Scientists Created Mice With Half-Human Brains. The Hybrid Animals Could Revolutionize Our Understanding of Neurological Disorders
Our brains and their associated diseases are notoriously hard to study. So researchers developed an animal model with a cortex—the brain’s outer layer—grown from human-derived cells
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L Brielmaier @lynnbr2.bsky.social · 20/09/2026
some Progress www.nature.com/articles/d41...
nature.com
First for RNA therapy: man with rare motor-neuron disease improves after treatment
Gene-targeting treatments could be used to treat other people with rare forms of amyotrophic lateral sclerosis (ALS).
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L Brielmaier @lynnbr2.bsky.social · 20/09/2026
efforts directed toward increasing TBK1 expression may provide a therapeutic approach for treating ALS/FTD caused by UBQLN2 mutations. www.sciencedirect.com/science/arti...
sciencedirect.com
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L Brielmaier @lynnbr2.bsky.social · 19/09/2026
Secret contracts reveal undisclosed terms in Trump’s drug-pricing deals wapo.st/4yKOpZm “But the more that is revealed, the more it becomes clear that they are designed to protect pharma’s pocketbooks, not patients.”
wapo.st
Secret contracts reveal undisclosed terms in Trump’s drug-pricing deals
Agreements with Pfizer and Eli Lilly include tariff protections, overseas pricing inducements and broad confidentiality clauses.
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L Brielmaier @lynnbr2.bsky.social · 18/09/2026
FDA-ordered studies of many drugs, devices on the market are not done Slow walking postmarket research allows companies to keep $elling. wapo.st/4jaNnBo
wapo.st
FDA-ordered studies of many drugs, devices on the market are not done
To get drugs and devices out faster, the FDA lets companies conduct studies of safety or efficacy after the products are approved. In many cases, such “postmarket” studies are behind schedule or overd...
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L Brielmaier @lynnbr2.bsky.social · 17/09/2026
the approach to phenotypic characterization and description meaningfully differs between the ALS and FTD communities. academic.oup.com/brain/advanc...
academic.oup.com
Conceptualizing cognition and behaviour across amyotrophic lateral sclerosis and frontotemporal dementia
Benatar et al. argue that studying the shared cognitive and behavioural features of ALS and FTD in separate disease silos has hampered scientific progress.
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IEEE Spectrum @spectrum.ieee.org · 16/09/2026
Do you have a small #server rack in your basement or garage? You can now rent it out for #AI inference and earn some passive income. For security, both the server host and the AI training company get the minimum access possible to accomplish what they need to do. spectrum.ieee.org/ai-inference...
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L Brielmaier @lynnbr2.bsky.social · 17/09/2026
Still a ways from getting me to walk again.
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L Brielmaier @lynnbr2.bsky.social · 17/09/2026
Human neurons flourish in mouse brains, offering a new view of neurodevelopmental disorders | Science The cortex, or outer layer of the brain—vital for cognition, attention, and decision-making—is composed almost entirely of neurons grown from human stem cells. www.science.org/content/arti...
science.org
Human neurons flourish in mouse brains, offering a new view of neurodevelopmental disorders
Method of replacing much of the mouse cortex with human “organoids” enables studies of brain diseases in a living nervous system
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L Brielmaier @lynnbr2.bsky.social · 16/09/2026
FDA launches pilot program to speed up early US drug research www.biopharmadive.com/news/fda-ope... via @BioPharmaDive program is meant to alter these trials trends by loosening “bottlenecks,” like ensuring trial site preparation & ethics reviews occur “in parallel” rather than “in sequence,”
biopharmadive.com
FDA launches pilot program to speed up early US drug research
First teased in June and formally announced Tuesday as part of “Operation Trialblazer,” the program will partner drugmakers with research institutions to more quickly bring medicines into human testin...
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L Brielmaier @lynnbr2.bsky.social · 16/09/2026
"This has the potential to change how we think about designing animal-assisted interventions, from hospitals and schools to therapeutic riding centers and beyond." medicalxpress.com/news/2026-09...
medicalxpress.com
Just 3 minutes with miniature horses and donkeys improves mood of teens
Interacting with animals can make people feel calmer, less lonely and less anxious. A new study from the University of California, Davis, shows that animals play an active role in shaping these intera...
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Reposted by L Brielmaier
Chronic Illness Humor @chronicillness.bsky.social · 15/09/2026
Christofferson Lab
@RC_Epi

A virus doesn’t actually want to kill you. Most of them want to use you.

screw it:

Some of them want to be used by you (phage).
Some of them want to abuse you (retros).
Some of them want to be abused (requires appropriate biosafety review).
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L Brielmaier @lynnbr2.bsky.social · 16/09/2026
Americans will soon be able to travel to Big Sky Country to take experimental drugs in defiance of federal regulators. www.politico.com/news/2026/09...
politico.com
Montana’s giving the biotech industry sweeping authority to sell unapproved drugs
Americans will soon be able to travel to Big Sky Country to take experimental drugs in defiance of federal regulators.
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L Brielmaier @lynnbr2.bsky.social · 15/09/2026
First Therapy to Target Muscle Loss in Spinal Muscular Atrophy Gets FDA Approval The drug is the first therapy approved for SMA that directly targets muscle loss, the FDA said. www.medpagetoday.com/neurology/ge...
medpagetoday.com
First Therapy to Target Muscle Loss in Spinal Muscular Atrophy Gets FDA Approval
Motor function may improve with adjunctive apitegromab
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L Brielmaier @lynnbr2.bsky.social · 14/09/2026
Americans Love Supplements, but Experts Doubt Their Benefits experts said there is little evidence for many of these products www.nytimes.com/2026/09/11/w...
nytimes.com
Americans Love Supplements, but Experts Doubt Their Benefits
A new survey found that 8 in 10 Americans were taking vitamins, protein powders or other supplements. But experts said there is little evidence for many of these products.
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L Brielmaier @lynnbr2.bsky.social · 11/09/2026
Silos sometimes come down. Boycott of the American Diabetes Association Launched www.medpagetoday.com/endocrinolog...
medpagetoday.com
Boycott of the American Diabetes Association Launched
Fallout after the removal of scientists from ADA's annual meeting in New Orleans continues
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L Brielmaier @lynnbr2.bsky.social · 11/09/2026
Everyone is wrong about low-turnout voters open.substack.com/pub/gelliott... It’s far past time for pundits to update the conventional wisdom about low-engagement voters. No, they are not MAGA!
open.substack.com
Everyone is wrong about low-turnout voters
They care most about affordability, and disapprove of Trump’s job as president at much higher rate than engaged voters — including among Republicans
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L Brielmaier @lynnbr2.bsky.social · 11/09/2026
Informed Consent Limbo: www.wired.com/story/egg-fr...
wired.com
A New Startup Lets You Freeze Your Eggs For Free. But Is Anything Ever Free?
Cofertility manages the costs of egg freezing and storage, in exchange for half the batch. One young client became suspicious of the arrangement—and started to investigate.
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L Brielmaier @lynnbr2.bsky.social · 10/09/2026
For ALS & FTD, there is a growing imperative to develop biomarkers that reflect the varied pathobiologies that underly these disorders. academic.oup.com/brain/advanc...
academic.oup.com
Progress towards a biotypic biomarker profile for amyotrophic lateral sclerosis–frontotemporal spectrum disorders
Strong et al. review current and emerging biomarkers for ALS, ALS-FTD and FTD, focusing on their ability to reveal underlying pathobiology prior to symptom
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L Brielmaier @lynnbr2.bsky.social · 10/09/2026
A.I. tools could take valuable insights from one user and hand them to another. www.nytimes.com/2026/09/10/s...
nytimes.com
Could Your Chatbot Be Stealing Ideas From You? It’s a Thorny Question. (Gift Article)
A controversy around OpenAI’s latest math proof raises a fear that might become increasingly common: that A.I. tools could take valuable insights from one user and hand them to another.
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L Brielmaier @lynnbr2.bsky.social · 10/09/2026
For ALS& FTD, there is a growing imperative to develop biomarkers that reflect the varied pathobiologies that underly these disorders, academic.oup.com/brain/advanc...
academic.oup.com
Progress towards a biotypic biomarker profile for amyotrophic lateral sclerosis–frontotemporal spectrum disorders
Strong et al. review current and emerging biomarkers for ALS, ALS-FTD and FTD, focusing on their ability to reveal underlying pathobiology prior to symptom
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Reposted by L Brielmaier
IEEE Spectrum @spectrum.ieee.org · 08/09/2026
DeepMind’s new AlphaGenome Atlas lets scientists explore the predicted effects of any single-letter change—without running the massive AI model themselves.
spectrum.ieee.org
DeepMind's AI Just Mapped 9 Billion Possible DNA Variants
AlphaGenome Atlas predicts how single-letter changes affect genes
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Bridging Voice @bridgingvoice.bsky.social · 08/09/2026
Trinity and Emily, two of Bridging Voice's brilliant SLPs, joined @Smartboxaac's Start the Chat podcast to share what goes into making eye gaze work in real life, and where the tech is headed next. Watch the full episode on our website at: bridgingvoice.org/trainings/st... #AAC #ALSawareness
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L Brielmaier @lynnbr2.bsky.social · 09/09/2026
hint: don't select Medicare DisAdvantage
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Reposted by L Brielmaier
IEEE EMBS @embs.org · 09/09/2026
SAVE THE DATE: #NER2027 🗓️ Sept. 7–10, 2027 📍 Politecnico di Milano | Milan, Italy 🔬 Clinical Translation 🤖 BCIs ⚡ Advanced Neurotechnologies 🧬 AI in Neural Engineering Stay tuned for details: neuro.embs.org/2027/welcome/?utm_so…
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L Brielmaier @lynnbr2.bsky.social · 09/09/2026
All polls are models now open.substack.com/pub/gelliott...
open.substack.com
All polls are models now
Traditional polling is dead. A new paradigm of public opinion research has high uncertainty, and pollsters need to do a better job communicating about error.
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Reposted by L Brielmaier
Chronic Illness Humor @chronicillness.bsky.social · 06/09/2026
i'm just a person who needs to get stuff done in a body that needs to lie down
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L Brielmaier @lynnbr2.bsky.social · 07/09/2026
Trump and Kennedy's Health Industry Deals Are at Risk of Vanishing www.medpagetoday.com/publichealth... "We've gotten rid of the nine synthetic-based food dyes," he said. Not quite. Later, the FDA on its website quietly changed the deadline to the end of 2027. So, most are still in use.
medpagetoday.com
Trump and Kennedy's Health Industry Deals Are at Risk of Vanishing
The deals lack the enforcement teeth of more traditional federal regulation
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L Brielmaier @lynnbr2.bsky.social · 07/09/2026
More Evidence Ties Microplastics to Lung Cancer www.medpagetoday.com/meetingcover... Experts currently advise certain measures to avoid microplastic exposure,
medpagetoday.com
More Evidence Ties Microplastics to Lung Cancer
Observational study shows greater microplastic burden in patients with lung malignancy
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