Parsons and colleagues characterize age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer using computational analysis of transcriptomic ...

Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell in...

The Roswell Park Emerging Leaders in Cancer Research Seminar Series features lectures by outstanding junior scientists from around the country on a diverse range of cancer-focused topics. This include...

T cells are generally sparse in hormone receptor-positive (HR+) breast cancer, potentially due to li

High mutational load tumors mitigate effects from protein-damaging mutations by up-regulating complexes that buffer against misfolding stress, revealing therapeutic vulnerabilities and suggesting disr...