iiinova — where your digital self keeps evolving

Luzeena Raja @luzeenaraja.bsky.social · 30/09/2026

Interested in exploring the dark proteome in various disciplines like cancer? www.orfeus-dn.eu is now live! 15 PhD positions across institutions in the EU as part of the Marie Curie Doctoral Network (MSCA-DN), including @simonelsasser.bsky.social at @uni-freiburg.de! Applications open Oct 1!

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SciLifeLab @scilifelab.se · 02/12/2025

“#Microproteins like PIPPI may turn out to be important regulators of how cells respond to stress, and could offer new clues for understanding disease mechanisms,” says @simonelsasser.bsky.social, Group Leader at SciLifeLab and @ki.se ↓🧪 Learn more: www.scilifelab.se/news/cancer-...

scilifelab.se

Cancer cells overcome stress with new microprotein uncovered by scientists at SciLifeLab

The researchers have tested more than 11,000 potential microproteins to identify which affect cell survival during stress, something that could lead to new therapies. Researchers in the Elsässer, Piaz...

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Reposted by Luzeena Raja

Erik Angner @erikangner.com · 27/11/2025

"Runctitiononal features"? "Medical fymblal"? "1 Tol Line storee"? This gets worse the longer you look at it. But it's got to be good, because it was published in Nature Scientific Reports last week: www.nature.com/articles/s41... h/t @asa.tsbalans.se

Infographic with AI slop published in Nature Scientific Reports

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Karolinska Institutet @ki.se · 27/11/2025

Researchers have performed a large-scale genetic screen to uncover the hidden roles of #microproteins. One of the discovered microproteins, named PIPPI, was found to protect cells from stress in the endoplasmic reticulum. Published in @narjournal.bsky.social 🧪 #proteomics news.ki.se/new-micropro...

news.ki.se

New microprotein can help cancer cells overcome stress

In a new study published in the journal Nucleic Acid Research, a research team at Karolinska Institutet has performed a large-scale genetic screen to uncover the hidden roles of tiny proteins, so-call...

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Luzeena Raja @luzeenaraja.bsky.social · 31/08/2025

Phenomenal first GRC on microproteins in Spain this month. Team Elsässer participated with a talk by @simonelsasser.bsky.social on the Pippi story (watch this space for more!), and posters by Alberto and I on our ongoing microprotein work /1

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Anne Carpenter @drannecarpenter.bsky.social · 19/03/2025

Finally the tides are starting to turn!! Cancer isn’t all about DNA mutations, nor even mRNA levels. We launched SyzOnc to map the proteins underlying deadly cancers that are not DNA-driven. journals.plos.org/plosbiology/...

journals.plos.org

The end of the genetic paradigm of cancer

Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

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Reposted by Luzeena Raja

Adriana Guatame-García @adriguatame.bsky.social · 06/03/2025

A friend included this anti-acknowledgement section on her PhD thesis. She also added the proposition: “Systematic bullying and undermining of girls and women in STEM starts early on and is the reason why they do not stay in science and related fields.” Absurd we still need to go through this 🧪👩‍🔬

There have been people less than helpful in my journey here. I wanted to acknowledge those too, bc I know I am not unique in this experience.
No thank you to the physics study assoc that made me sing songs about how women couldn't study physics without sleeping with the professor, the day I stepped into university life. No thank you to the 5th year physics student that decided to assign me a stripper name within the first minute of meeting me in the physics coffee corner in my first year. No thank you to the technician that was responsible for onboarding me on the use of the cluster in my third year who raised his eyebrows and asked me if that meant I was some sort of computer girl. No thank you to the senior researcher that sent me utterly inappropriate texts after a conference, then proceeded to apologise months later by telling me they had not been meant for me anyway so no hard feelings remain hopefully And no thank you to him for attending every conference I've been to since. No thank you to the people who told me that it was surprising that I was doing a PhD since I was a girl. No thank you to the man who mistook me for a coffee lady at a conference, and after having to correct him two times that I did not work there, responded with you should consider it. No thank you to the researcher that asked me what I was wearing underneath my outfit during a conference. No thank you to the physicist who declared to a room full of other physicists that biologists don't know how to design an experiment. No thank you to the people who have called me scary instead of strong and intimidating instead of intelligent.
And finally, no thank you to the exec board of the TU Delft, whose knee-jerk reaction to being held up a mirror about the social safety at the university, was to sue the party holding up the mirror instead of looking at the problems they highlighted.
... You have made me feel like I do not belong in science & I cannot forgive you for that.

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Dr. Thomas Martínez @thomasmartinez.bsky.social · 06/03/2025

Fantastic work and a real tour de force from @simonelsasser.bsky.social and his talented team! Happy to be able to contribute to their efforts! 🎉👏

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Elsässer Lab @simonelsasser.bsky.social · 06/03/2025

It feels a little bit postclimactic to post this now, after the first version of our paper hit bioRxiv when X was still a thing that people used, the revised version was formally accepted at Cell Community past November. But here is the final print version of our paper www.cell.com/iscience/ful...

cell.com

A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness

molecular genetics, classification of proteins, methodology in biological sciences, cancer, and cell biology

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Elsässer Lab @simonelsasser.bsky.social · 06/03/2025

...but please do read the latest version, with deepened mass spec support and additional analyses. And a final thanks for being in for the long haul Dörte, Lorenzo, Carmen, @plantproteomics-ms.bsky.social @thomasmartinez.bsky.social, @luzeenaraja.bsky.social co-authors! www.cell.com/iscience/ful...

cell.com

A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness

molecular genetics, classification of proteins, methodology in biological sciences, cancer, and cell biology

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Reposted by Luzeena Raja

John Prensner @johnprensner.bsky.social · 06/03/2025

Congrats @simonelsasser.bsky.social and so excited to see this work in print! #genomics #bioinformatics #RNAsky 🔎 #microproteins 🧬 💻 #RiboSeq #ncORFs

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Trends in Genetics @cp-trendsgenetics.bsky.social · 03/02/2025

TiG's February issue is devoted to microproteins and the small ORFs that encode them. Check it out! www.cell.com/trends/genet...

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