iiinova — where your digital self keeps evolving

Life Science Alliance @lsajournal.org · 15h

New function! TTF2 has a role in restricting RNA Polymerase I reactivation at mitotic exit, ensuring proper synthesis of rDNA and nucleolar organisation. @raoliveira.bsky.social @reviewcommons.org www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 03/10/2026

New study: PZL-26 selectively inhibits mitochondrial protease LONP1, sparing the proteasome. CRISPR screening and proteomics reveal LONP1's roles in OXPHOS and mitochondrial gene expression. www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 03/10/2026

Conserved MEIS1 drives human cortical expansion. A human-specific non-coding RNA regulates MEIS1 to coordinate primary cilia morphology, preserving neural progenitor proliferation. www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 02/10/2026

This study uses a combination of molecular biochemistry and cell biology approaches to identify a novel function for a non-coding RNA and protein interaction in promoting human cell survival. @ucsdchem.bsky.social www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 02/10/2026

Check out this recently published paper in LSA: Murine IL-2 outperforms human IL-2 in supporting the survival of naïve mouse CD8 T cells in vitro ➡️ www.life-science-alliance.org/content/9/12... @bsheridanlab.bsky.social @stonybrookmedicine.bsky.social

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Life Science Alliance @lsajournal.org · 02/10/2026

In our October issue: Combining two spatial transcriptomics probe sets on the same sample, how epithelial cells remember prior physical constraints, and a novel single-cell translation profiling technique! www.life-science-alliance.org/content/9/10

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Life Science Alliance @lsajournal.org · 01/10/2026

Check out this recently published paper in LSA: Proteomics of heterogeneous megakaryocytes identifies JI051 as an enhancer of platelet biogenesis ➡️ www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 01/10/2026

New Research paper in LSA: Fetal growth restriction leads to prolonged nephrogenesis and gene dysregulation in the adult kidney👇 www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 30/09/2026

This study shows that an N-terminal degradation tag can alter RAF1 function before protein removal, highlighting the need to validate tagged proteins in disease models. www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 30/09/2026

“From acceptance to print took only a matter of days.”—Diana P. Bratu @thegraduatecenter.bsky.social. Publish in LSA, a network that works for you. hubs.la/Q04wLKy20

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Life Science Alliance @lsajournal.org · 25/09/2026

Murine IL-2 promotes the survival of naïve mouse CD8 T cells in vitro compared to human IL-2 and induces a distinct expression pattern of IL-2 receptors in activated CD8 T cells. @bsheridanlab.bsky.social @stonybrookmedicine.bsky.social www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 25/09/2026

Drug-induced metabolic remodeling promotes antimicrobial activity in macrophages and extends longevity in vivo @rutgersuniversity.bsky.social @rutgersresearch.bsky.social www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 24/09/2026

This study establishes a proteomics platform to elucidate megakaryocyte heterogeneity and identifies JI051 as a compound that enhances platelet-like particle generation with bioproduction potential. www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 24/09/2026

A mouse model of fetal growth restriction reveals prolonged kidney development and gene dysregulation in adulthood, suggesting that late gestational and early postnatal periods are crucial for preventing chronic kidney disease (CKD). www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 23/09/2026

“The review process was streamlined and fast, and communication with the scientific editor was always prompt and genuinely helpful.”—Diana P. Bratu @thegraduatecenter.bsky.social. Publish in LSA, a network that works for you. hubs.la/Q04wLKy20

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Life Science Alliance @lsajournal.org · 23/09/2026

New research shows that an N-terminal dTAG cassette alters RAF1 scaffold function in KRAS-driven lung cancer models before degradation, underscoring the importance of validating tagged proteins. #CancerResearch #TPD www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 18/09/2026

A potent antimicrobial promotes mitochondrial fission & mitophagy, boosting the effectiveness of macrophages to defend against bacterial infection & promoting lifespan extension in C. elegans. @rutgersuniversity.bsky.social @rutgersresearch.bsky.social www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 17/09/2026

Proximity labeling reveals ZFP36L1 as a central hub for post-transcriptional regulatory networks in T cells. #Immunology #TCells @sanquin-forlife.bsky.social @oncodeinstitute.bsky.social @monikawolkers.bsky.social www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 16/09/2026

“We came to LSA through a recommendation from a JCB editor to transfer our study to their not-for-profit, open-access sister journal, and we are very glad we accepted that invitation.”—Diana P. Bratu @thegraduatecenter.bsky.social. Publish in LSA, a network that works for you. hubs.la/Q04wLKy20

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Life Science Alliance @lsajournal.org · 16/09/2026

Check out this new LSA article! MAFF is a transcription factor that regulates contraction-induced skeletal muscle transcription. www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 11/09/2026

Have you already had a chance to look at this Research Article recently published in LSA: Induced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97Ufd1-Npl4 complex @unidue-zmb.bsky.social @hemmo-lab.bsky.social www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 10/09/2026

Using proximity labeling, the authors map the ZFP36L1 interactome, revealing diverse interactions and their potential roles during T-cell activation. @sanquin-forlife.bsky.social @oncodeinstitute.bsky.social @monikawolkers.bsky.social www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 09/09/2026

Acute exercise robustly induces MAFF in human and mouse skeletal muscle, and loss of MAFF in C2C12 myotubes impairs myogenic fusion and attenuates contraction-induced transcriptional programs. www.life-science-alliance.org/content/9/12...

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Life Science Alliance @lsajournal.org · 09/09/2026

Single-nucleus multiomics identifies a β-cell subpopulation mounting an early interferon-driven inflammatory response to a high-fat diet, with traces of this signature detected in human diabetes. www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 04/09/2026

The p97-Ufd1-Npl4 complex targets ubiquitylated RAD21 to extract a subpopulation of cohesion specifically in S-phase to facilitate DNA replication and suppress replication-associated DNA damage. @unidue-zmb.bsky.social @hemmo-lab.bsky.social www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 04/09/2026

Take a look at this recently published paper in LSA: Proliferation and differentiation in intestinal organoids are balanced by ligand-modulated EGFR trafficking. www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 03/09/2026

Check out this new article at LSA! Interleukin-1 mediates innate immune signaling and antiviral defense in islets. @medicalcollegeofwi.bsky.social www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 02/09/2026

Single-nucleus multiomics reveals an early inflammatory response to a high-fat diet in a subset of pancreatic β-cells, implicating inflammation in the loss of β-cell identity during metabolic stress. www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 01/09/2026

In our September issue: how CDK4/6 inhibition drives senescence, the first peroxisome interactome map, and a cheap workflow for single-cell proteomics. Read these and more here! www.life-science-alliance.org/content/9/9

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Life Science Alliance @lsajournal.org · 01/09/2026

This study identifies diagnosis-stage chromatin accessibility features associated with relapse-prone pediatric AML across molecular subtypes. www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 31/08/2026

Check out this new article at LSA! Interactions of LINE-1 ORF1p with proteins and chromatin suggest a role in neuronal physiology. @cirbcdf.bsky.social www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 28/08/2026

Medium ligand composition and concentration modulate EGFR signaling competency at the plasma membrane, balancing crypt proliferation and villus differentiation, and enhancing mouse intestinal organoid self-renewal. www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 28/08/2026

Confined epithelial tissues encode pressure history into cell-cycle activity, enabling colonies of different densities to converge on the same size and density upon release. @swaminathanlab.bsky.social www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 27/08/2026

In vivo innate immune activation results in IL-1-dependent expression of antipathogen defense response genes and attenuates picornavirus replication in islets. @medicalcollegeofwi.bsky.social www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 26/08/2026

Legionella pneumophila effector RavH acts as a membrane-dependent actin nucleator on organelles enriched with PI(3)P, revealing a mechanism that may support early vacuole dynamics during infection. www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 25/08/2026

Single-cell chromatin profiling study identifies diagnosis-stage regulatory features associated with relapse-prone pediatric AML, highlighting immune/inflammatory programs and transcription factor networks. www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 24/08/2026

ORF1p, a LINE-1-encoded protein, regulates chromatin accessibility, neuron-specific gene expression, and neurite morphology in post-mitotic neurons, revealing a physiological role for this retrotransposon protein in the brain. @cirbcdf.bsky.social www.life-science-alliance.org/content/9/11...

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Life Science Alliance @lsajournal.org · 21/08/2026

How do expanding epithelial tissues 'know' when to stop? Mechanical pressure during confinement acts as a tissue-scale memory regulating cell activity, driving convergence to the same final size regardless of starting density. @swaminathanlab.bsky.social www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 19/08/2026

Researchers identify Legionella effector RavH as a membrane-dependent actin nucleator that assembles actin on PI(3)P-rich membranes, uncovering a new strategy for host-cell manipulation during infection. www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 17/08/2026

"Clonal LIMD1 loss drives PD‑L1 immune evasion via ARIH1‑dependent ubiquitination in lung cancer" @qmbci.bsky.social www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 17/08/2026

Have you already read this paper, recently published in LSA? Structural interplay of the redox co-chaperone CnoX to GroEL/ES chaperonin www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 12/08/2026

During Drosophila oogenesis, the unfolded protein response induces ATF4-dependent Bruno 1, remodeling P-bodies to protect selected mRNAs from stress-induced degradation before stress granules form. @thegraduatecenter.bsky.social www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 11/08/2026

Check out this interesting article recently published in LSA: "A cardiac-related, promoter-proximal, regulatory element shapes chromatin and JAG1 transcription" www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 10/08/2026

Lung cancer tumour suppressor LIMD1 regulates the immune checkpoint protein PD-L1 via miRNA regulation and ARIH1-dependent ubiquitination. Low LIMD1 expression was enriched among responders to immune checkpoint blockade. @qmbci.bsky.social www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 10/08/2026

Cryo-EM structures reveal how the redox co-chaperone CnoX is accommodated during the GroEL reaction cycle and how GroES binding remodels the apical domains to promote CnoX release. www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 09/08/2026

In Genetics, Genomics, and Epigenomics: Tissue-Specific EEF1D Splicing, EEF1B complex KTN1 @qst-japan.bsky.social www.life-science-alliance.org/content/gene...

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Life Science Alliance @lsajournal.org · 06/08/2026

Take a look at this recently published paper in LSA: The transcriptional cortical response to daily torpor in Phodopus sungorus @manuelfriese.bsky.social www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 06/08/2026

Study in Genetics, Genomics, and Epigenomics collection reveals that two distinct genetic causes of Parkinson's disease push brain cells onto the same harmful path, increasing their vulnerability long before symptoms appear. www.life-science-alliance.org/content/gene...

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Life Science Alliance @lsajournal.org · 05/08/2026

P-bodies rapidly remodel in response to ER stress—before stress granules form—to preserve selected mRNAs via the ATF4–Bruno 1 pathway during Drosophila oogenesis. @thegraduatecenter.bsky.social www.life-science-alliance.org/content/9/10...

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Life Science Alliance @lsajournal.org · 05/08/2026

“Life Science Alliance is recognized globally as a respectable journal. Within the community, it stands out for its focus on scientific integrity, ensuring that robust data is shared globally.” — Jérémie Rossy, University of Konstanz. Learn more: hubs.ly/Q04ldCnb0

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