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Loïc Labache

@loiclabache.cpesr.fr
269 followers 692 following 27 posts

Postdoctoral Fellow at Rutgers University Previously CEA 🇫🇷, Yale 🇺🇸 Website: loiclabache.github.io Cognitive neuroscientist and statistician interested in hemispheric specialization 🧠

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Reposted by Loïc Labache
Ahmad Beyh @ahmadbeyh.bsky.social · 24/08/2026
⚠️ Preprint alert ⚠️ How does the brain's fixed anatomy support flexible function? We explore this using recurrent neural networks with increasing levels of brain-like constraints, comparing them to empirical fMRI activity. (1/8) www.biorxiv.org/content/10.6...
biorxiv.org
Geometric constraints and cognitive inputs jointly shape emergent brain dynamics and topology
How the brain's physical geometry gives rise to its flexible functional repertoire remains a central question in neuroscience. Here, we trained three classes of recurrent neural networks (RNNs) on a w...
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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · 21/07/2026
So excited to share that our study is out now in @natcomms.nature.com! 🧠🚨 www.nature.com/articles/s41... Big shout out to coauthors @sidchop.bsky.social @ashleasegal.bsky.social @loiclabache.bsky.social Rowena Chin Kaley Joss & @avramholmes.bsky.social
nature.com
Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease - Nature Communications
Cocuzza et al. show that brain network dynamics are less flexible in psychiatric illness, and these patterns predict individual symptom profiles better than diagnoses, highlighting brain dynamics as a...
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Avram Holmes @avramholmes.bsky.social · 06/07/2026
Hemispheric specialization is core to brain organization, but its biological basis has been unclear. New @holmeslab-bhi.bsky.social paper links neurochemical & cellular asymmetries to left-lateralized language & right-lateralized attention networks, with implications for evolution & psych illness.
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Loïc Labache @loiclabache.cpesr.fr · 03/07/2026
Thank you! Glad you enjoyed it 🧠
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Loïc Labache @loiclabache.cpesr.fr · 03/07/2026
Thanks! Really appreciate it! 🙂
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Loïc Labache @loiclabache.cpesr.fr · 02/07/2026
Grateful to @sidchop.bsky.social, @xi-hanzhang.bsky.social & @avramholmes.bsky.social for a fantastic collaboration, and to @cahbir.bsky.social for making this work possible 🧠
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Loïc Labache @loiclabache.cpesr.fr · 02/07/2026
Happy to share that our work is finally published in @commsbio.nature.com! We identify molecular and cellular signatures of hemispheric specialization, linking language and attention to distinct neurotransmitter, mitochondrial, & cellular organization across the cortex 🧠 doi.org/10.1038/s420...
doi.org
Molecular and cellular correlates of human cortical lateralization - Communications Biology
Multimodal analyses reveal the molecular and cellular asymmetries underlying human cortical lateralization. Distinct neurotransmitter, mitochondrial, and cellular gradients support left-lateralized la...
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Sidhant Chopra @sidchop.bsky.social · 29/06/2026
🧠 New work showing prominent and widespread 𝘪𝘯 𝘷𝘪𝘷𝘰 pre-synaptic terminal reductions in people with schizophrenia.🧠 nature.com/articles/s41... Strongest effects in left hemisphere, but synaptic loss didn't track with MRI grey matter alterations, but did align with..👇1/4
nature.com
Widespread synaptic density loss in schizophrenia follows molecular and network architecture - Molecular Psychiatry
Molecular Psychiatry - Widespread synaptic density loss in schizophrenia follows molecular and network architecture
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Armin Raznahan @bogglerapture.bsky.social · 28/05/2026
Do humans show sex differences in brain activation? If so, are these task-specific or general — and do they relate to sex differences in brain anatomy and behavior? We dove deep into these questions in a new paper just out in Nature Communications | tinyurl.com/3rdrb524
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Phil Corlett @philcorlett.bsky.social · 23/04/2026
Did we just discover that association cortex has...associations?
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Niki Hubbard, PhD 🐙🦀 @nikihubbard.bsky.social · 30/03/2026
Once upon a time I just admired nudis and sea slugs. But it was not enough. Now apparently I'm creating an R package to celebrate their colour palettes? 😅 First up, my Sydney fave, Hypselodoris bennetti. #rstats #nudibranch #dataviz 🦑🐙🧪 #marinelife #invertebrates
Close up with a beautiful nudibranch on a rocky reef. The lower half of the image is a palette of swatches made from the nudi's vibrant colours.
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Yueyue Lydia Qu @lydiaquq.bsky.social · 30/03/2026
Now out in Psychological Medicine! We identified lifetime exposures to humiliation and entrapment, as well as frontoparietal-left cerebellar RSFC, as correlates of adolescent anxiety and depression symptoms across three time points. Link: doi.org/10.1017/S003...
doi.org
Life experiences of humiliation, entrapment, and frontoparietal-cerebellar connectivity predict adolescent anxiety and depression symptoms | Psychological Medicine | Cambridge Core
Life experiences of humiliation, entrapment, and frontoparietal-cerebellar connectivity predict adolescent anxiety and depression symptoms - Volume 56
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Konrad Kording @kordinglab.bsky.social · 09/02/2026
neuroAI comparisons of ANNs to brains do have a range of problems. Even more than I had realized. And I was worried before: www.biorxiv.org/content/10.1...
biorxiv.org
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Peter Kirk @peterakirk.bsky.social · 03/02/2026
Our latest work on the neurobiology of subjective emotional experience in anxiety is out now in SCAN 🧠 Brief summary below 👇 doi.org/10.1093/scan...
doi.org
Linking subjective experience of anxiety to brain function using natural language processing
Abstract. Research on anxiety focuses on clinically relevant behaviours and neurophysiological responses, particularly emphasizing recruitment of amygdala,
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Avram Holmes @avramholmes.bsky.social · 18/12/2025
Spread the word: new PhD track in Biomedical Informatics and Health AI - enrollment for Fall 2026 closing soon! www.linkedin.com/feed/update/...
linkedin.com
Please spread the word: new PhD track in Biomedical Informatics and Health AI - enrollment for Fall 2026 closing soon! | Antonina Mitrofanova
Please spread the word: new PhD track in Biomedical Informatics and Health AI - enrollment for Fall 2026 closing soon!
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Loïc Labache @loiclabache.cpesr.fr · 05/12/2025
Thank you for these clarifications!
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Loïc Labache @loiclabache.cpesr.fr · 01/12/2025
@ohbmofficial.bsky.social, Is the new OHBM abstract length really 14,000 characters?
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Janine Bijsterbosch @janinebijsterbosch.bsky.social · 24/11/2025
@ohbmofficial.bsky.social, is the new OHBM abstract length really 14,000 characters? This would mean a shift from an abstract to a conference paper. If so, what are the implications for publication rights with respect to journal submissions? How are reviewers expected to review up to 40?
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Holmes Lab @holmeslab-bhi.bsky.social · 11/11/2025
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you’re interested 👀 Find out more holmeslab.rutgers.edu
Flyer to join Holmes Lab
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Avram Holmes @avramholmes.bsky.social · 11/11/2025
Looking for a post-bac RA position focused on the brain bases of affective and psychotic illness? @holmeslab-bhi.bsky.social is hiring! @cahbir.bsky.social @rutgersbhi.bsky.social @rutgersu.bsky.social @sobp-org.bsky.social @hitop-system.bsky.social @ohbmofficial.bsky.social
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Emily G. Jacobs @emilyjacobs.bsky.social · 05/09/2025
One to watch! 👇🏼🔥 Be sure to tune in Monday for the live event or check out the recording on youtube, along with all our WBHI lectures. Register for the full series at wbhi.ucsb.edu/about/events We’ve got an amazing 25-26 lineup.
wbhi.ucsb.edu
Events
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Jérémie Naudé @jeremie-n.cpesr.fr · 04/09/2025
Les espèces classiques de la SVT : se reproduisent 🥱 Les reines des fourmis M. ibericus : clonent des mâles d'une autre espèce 🤯 pour se reproduire avec et créer des ouvrières hybrides 😤 tout en faisant des mâles de leur espèce pour faire des nouvelles reines 💃💃 www.nature.com/articles/s41...
nature.com
One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
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Imaging Neuroscience @imagingneurosci.bsky.social · 03/07/2025
New paper in Imaging Neuroscience by Elise Roger, Gaelle E. Doucet, et al: When age tips the balance: A dual mechanism affecting hemispheric specialization for language doi.org/10.1162/IMAG...
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Loïc Labache @loiclabache.cpesr.fr · 03/07/2025
Excited to share that our work is now published in Imaging Neuroscience! 🧠🥳 We show how aging reshapes the brain’s language and memory networks, revealing striking shifts in hemispheric specialization across the lifespan. Check it out @imagingneurosci.bsky.social
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Loïc Labache @loiclabache.cpesr.fr · 03/07/2025
Thanks so much! Great to hear you enjoyed the work.
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Holmes Lab @holmeslab-bhi.bsky.social · 28/06/2025
Holmes Lab is representing at #OHBM2025! 🧵 Loic @loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠
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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · 04/06/2025
🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇
nature.com
The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry - Scientific Data
Scientific Data - The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry
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Carrisa V. Cocuzza, PhD (she/her) @carrisacocuzza.bsky.social · 30/05/2025
🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘 www.biorxiv.org/content/10.1... Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
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Loïc Labache @loiclabache.cpesr.fr · 05/05/2025
Thanks Donna! I take that as a compliment; hope the surprise wasn't too big.
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Annie G. Bryant @anniegbryant.bsky.social · 04/05/2025
🎨🧑‍🎨 Looking for a tool to visualize subcortical/thalamic data in 2D? Check out this python-based package I put together (subcortex-visualization on PyPI), plus a guide for creating your own custom atlas meshes and vector graphics! All feedback/tips welcome 😊 anniegbryant.github.io/subcortex_vi...
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Peter Kirk @peterakirk.bsky.social · 02/05/2025
Check our latest work ‘Linking Subjective Experience of Anxiety to Brain Function using Natural Language Processing’. Our analyses link movie-evoked brain activity and subsequent interview recordings in a pediatric sample with and without anxiety disorders (doi.org/10.31234/osf...).
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Linden Parkes @lindenmp.bsky.social · 28/04/2025
Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘 www.biorxiv.org/content/10.1...
media.tenor.com
a man applauds with the words so proud of my team above him
ALT: a man applauds with the words so proud of my team above him
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Holmes Lab @holmeslab-bhi.bsky.social · 15/04/2025
Newest #preprint from Holmes lab postdoc @loiclabache.bsky.social 🔥
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Loïc Labache @loiclabache.cpesr.fr · 15/04/2025
Thanks, Clyde! I hope you enjoy reading it!
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Avram Holmes @avramholmes.bsky.social · 12/04/2025
The molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
Thanks so much! So glad you found the work interesting. The development of lateralization is a fascinating path to explore!
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
Thanks Cedric! 🙏
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
9/ Huge thanks to @avramholmes.bsky.social @holmeslab-bhi.bsky.social and big ups to collaborators @sidchop.bsky.social and @xi-hanzhang.bsky.social across Yale & Orygen 🦘
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
8/ Understanding these biological bases of lateralization has profound implications for evolutionary theory and offers clues to neuropsychiatric conditions characterized by atypical lateralization patterns.
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
7/ Finally, our findings reveal a distinct cellular and molecular fingerprint demonstrating the brain is organized around two complementary systems: one centered around language and the other around visuospatial attention.
Figure of the organization of the molecular and cellular profiles of the seven canonical intrinsic networks. We are revealing the existence of opposing lateralization profiles in language- and attention-related networks at the molecular and cellular level.
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
6/ On the cellular level, intratelencephalic-projecting neurons and microglia distributions align with hemispheric specialization, linking specific cell-types to cognitive functions like language and attention.
Figure of the cellular substrates of the neurotransmitter receptor and transporter mode underlying functional cortical lateralization.
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
5/ We further discovered mitochondrial activity asymmetry aligns with this neurotransmitter axis, suggesting energy management in cells plays a pivotal role in supporting cognitive specialization.
Figure of the molecular substrates of neurotransmitter receptor and transporter modes underlying functional cortical lateralization. We show mitochondrial phenotypes as substrates for lateralization of the acetylcholine-norepinephrine axis.
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
4/ Left-hemisphere language dominance correlates with higher norepinephrine transporter densities, whereas right hemisphere visuospatial attention is associated with increased acetylcholine receptor densities.
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
3/ Our multimodal approach integrates fMRI, PET imaging, and transcriptomic analyses, uncovering an acetylcholine-norepinephrine neurotransmitter axis central to functional lateralization.
Canonical Correlation Analysis (CCA) results reveal the neurotransmitter receptor and transporter substrates underlying functional cortical lateralization. We are showing that an acetylcholine-norepinephrine axis
underlines functional lateralization of language and visuospatial attention.
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
2/ Hemispheric specialization is crucial for human cognition. The left hemisphere typically dominates language, while the right is in charge of visuospatial attention. But what's the biology behind this division?
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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025
🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence
doi.org
The molecular and cellular underpinnings of human brain lateralization
Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...
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The Transmitter @thetransmitter.bsky.social · 08/04/2025
Until recently, in-vivo brain imaging has largely been absent from… integrative efforts, limiting the opportunities to contribute our discoveries, theories or vision toward a comprehensive view of brain function, writes @avramholmes.bsky.social. #neuroskyence www.thetransmitter.org/future-of-fm...
thetransmitter.org
fMRI must break out of its silo
We need to develop research programs that link phenomena across levels, from genes and molecules to cells, circuits, networks and behavior.
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Sidhant Chopra @sidchop.bsky.social · 24/03/2025
🧩New study: "Network Constraints on 𝘪𝘯 𝘷𝘪𝘷𝘰 Synaptic Alterations in Schizophrenia" medrxiv.org/content/10.1... We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇
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Holmes Lab @holmeslab-bhi.bsky.social · 03/03/2025
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Unfortunately, we cannot sponsor visas for this position. Please rt and reach out if you're interested👀
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Loïc Labache @loiclabache.cpesr.fr · 25/02/2025
📢 Excited and honored to have our latest work on the molecular and cellular underpinnings of human brain lateralization accepted for an oral and poster presentation at #OHBM2025! 🎉 Catch it at poster #1792 and in the Language: Anatomy, Networks, and Pathology oral session. 🔜 Preprint coming soon! 🧠
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