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Loïc Labache

@loiclabache.cpesr.fr

276 followers 698 following 41 posts

Postdoctoral Fellow at Rutgers University Previously CEA 🇫🇷, Yale 🇺🇸 Website: loiclabache.github.io Cognitive neuroscientist and statistician interested in hemispheric specialization 🧠

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Loïc Labache @loiclabache.cpesr.fr · 12/10/2026

Meanwhile, CROWDED individuals showed higher fiber-density estimates across widespread white-matter connections, with strong involvement of dorsal attention and default networks. The differences went far beyond any single tract.

Structural connectivity.
Chord diagram illustrating widespread structural connectivity differences associated with Crowded organization, both within and between brain networks. Ribbon thickness and color represent the proportion of significant connections.

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Loïc Labache @loiclabache.cpesr.fr · 12/10/2026

These configurations also had distinct brain signatures! Individuals with MIXED organization showed higher cortical myelination in the left planum polare compared with SPLIT and CROWDED individuals. This links hemispheric organization to differences in cortical microstructure.

Cortical myelination.
Cortical surface maps showing differences in myelination across Split, Mixed, and Crowded configurations. Black outlines highlight a significant cluster in the left planum polare.

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Loïc Labache @loiclabache.cpesr.fr · 12/10/2026

Next, we combined attention and language lateralization to define 3 cross-domain configurations: ↔️ SPLIT (44%): opposite dominant hemispheres 🔀 MIXED (39%): neither split nor crowded ➡️ CROWDED (17%): same dominant hemisphere

Hemispheric complementarity.
Alluvial diagram linking attention and language lateralization, revealing three configurations: Split (n=437; opposite hemispheres), Mixed (n=386), and Crowded (n=164; same hemisphere). Ribbon widths represent participant counts.

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Loïc Labache @loiclabache.cpesr.fr · 12/10/2026

Importantly, the bilateral profile was NOT just a midpoint between left- and right-dominant attention. It showed stronger within-network functional connectivity and stronger coupling between corresponding regions across the hemispheres.

Functional connectivity.
Resting-state connectivity across the three attention phenotypes in dorsal and ventral networks: hemispheric strength asymmetry (top), overall network strength (middle), and interhemispheric functional connectivity (bottom).

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Loïc Labache @loiclabache.cpesr.fr · 12/10/2026

First, attention-related networks showed 3 distinct organizational profiles: 🟠 Right-dominant: 45% 🟣 Bilateral: 39% 🟢 Left-dominant: 16% So right-hemisphere dominance is common, but far from universal.

Attention phenotypes.
Hierarchical clustering of 987 participants identified three attention phenotypes: Typical (orange, n=447; rightward dominance), Bilateral (purple, n=386; no clear dominance), and Atypical (teal, n=154; leftward dominance).

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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025

7/ Finally, our findings reveal a distinct cellular and molecular fingerprint demonstrating the brain is organized around two complementary systems: one centered around language and the other around visuospatial attention.

Figure of the organization of the molecular and cellular profiles of the seven canonical intrinsic networks. We are revealing the existence of opposing lateralization profiles in language- and attention-related networks at the molecular and cellular level.

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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025

6/ On the cellular level, intratelencephalic-projecting neurons and microglia distributions align with hemispheric specialization, linking specific cell-types to cognitive functions like language and attention.

Figure of the cellular substrates of the neurotransmitter receptor and transporter mode underlying functional cortical lateralization.

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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025

5/ We further discovered mitochondrial activity asymmetry aligns with this neurotransmitter axis, suggesting energy management in cells plays a pivotal role in supporting cognitive specialization.

Figure of the molecular substrates of neurotransmitter receptor and transporter modes underlying functional cortical lateralization. We show mitochondrial phenotypes as substrates for lateralization of the acetylcholine-norepinephrine axis.

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Loïc Labache @loiclabache.cpesr.fr · 12/04/2025

3/ Our multimodal approach integrates fMRI, PET imaging, and transcriptomic analyses, uncovering an acetylcholine-norepinephrine neurotransmitter axis central to functional lateralization.

Canonical Correlation Analysis (CCA) results reveal the neurotransmitter receptor and transporter substrates underlying functional cortical lateralization. We are showing that an acetylcholine-norepinephrine axis
underlines functional lateralization of language and visuospatial attention.

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Loïc Labache @loiclabache.cpesr.fr · 29/12/2024

Love this "Where is Waldo" end-of-the-year science special edition from @imagingneurosci.bsky.social! 🧠🎉 Curious about Waldo? Find out more here: doi.org/10.1162/imag... #neuroscience

The image is a collage of figures from the 350 papers published in Imaging Neuroscience in 2024. A blue arrow points to a blue circle highlighting the image illustrating the ALANs atlas (Atlas for the Lateralized Visuospatial Attention Networks). Original collage by Imaging Neuroscience.

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