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Reposted by Lillian Wu

The Downs Lab @thedownslab.bsky.social · 13/07/2026

So nice to see Pierre's @pierrecaron.bsky.social highlight of our preprint (led by @lillianwu.bsky.social ) was selected by @jcellsci.bsky.social to include in their latest issue. Also, what a great initiative - ended up reading them all! prelights.biologists.com/highlights/c...

prelights.biologists.com

CENP-B binds hairpin motifs in chromosome arms influencing gene expression - preLights

CENP-B escapes the centromere and plays a surprising role in gene regulation

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Reposted by Lillian Wu

The Downs Lab @thedownslab.bsky.social · 13/04/2026

New preprint from the lab! Our awesome @lillianwu.bsky.social drove this project with contributions from @kezlane.bsky.social @alison-harrod.bsky.social and collaborators @andrea-musacchio.bsky.social @chromatinlab.bsky.social and @claudioalfieri.bsky.social #CENP-B www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Lillian Wu

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 13/04/2026

CENP-B binds hairpin motifs in chromosome arms influencing gene expression www.biorxiv.org/content/10.64898/20…

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Reposted by Lillian Wu

The Downs Lab @thedownslab.bsky.social · 27/10/2025

Congratulations to Dr Noa Amin (times two since she was already a medical doctor but now has an amazing PhD)!!! #proudsupervisor Beautiful @icr.ac.uk award ceremony at the Guildhall

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Reposted by Lillian Wu

The Downs Lab @thedownslab.bsky.social · 05/03/2025

If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...

nature.com

PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications

Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...

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