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Laura Gutiérrez-Miranda

@lgutimiranda.bsky.social
531 followers 699 following 21 posts

Tiny scientist glued to a microscope 🔬. Postdoc at @lymphaticslab.bsky.social Uppsala. Former @weizmann @dkfz.bsky.social alumna #zebrafish #vascularbiology #lymphatics #marrow #microscopy 🧬✂️

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Reposted by Laura Gutiérrez-Miranda
Kaska Koltowska @lymphaticslab.bsky.social · 20/08/2026
Proud to share our new paper in EMBO Reports! 🧬 How does a cell "decide" to become lymphatic vs blood endothelium? Turns out it's not just which genes switch on — it's how the genome folds around them. 💥 link.springer.com/content/pdf/... #Lymphatics #Zebrafish #DevBio #VascularBiology #Genomics
The topologically associating domains (TADs) and chromatin accessibility of lymphatic endothelial cells diverge from those of blood endothelial cells. These differences underlie the activation of LEC-specific regulatory networks governing cell identity and involving genes linked to lymphatic disease.
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Jane Goodall Institute of Canada @janegoodallcan.bsky.social · 01/10/2025
Dr. Jane made an indelible mark on our understanding of chimpanzees and other species, and also of humankind and the environments we all share. She inspired curiosity, hope, and compassion in countless people, and paved the way for many others. #ThankYouJane #RememberingJane Photo: Marko Zlousic
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Journal of Experimental Medicine @jem.org · 21/08/2025
Bassi et al. @karinayaniv.bsky.social @weizmanninstitute.bsky.social use #zebrafish to help identify new treatments for a severe lymphatic malformation. rupress.org/jem/article/... #CardiovascularBiology #HumanDiseaseGenetics
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Reposted by Laura Gutiérrez-Miranda
Kevin Thiessen, PhD @kevinthiessen.bsky.social · 18/05/2025
My Bioinformatics Bootcamp turned blog! Enjoy this collection of free #zebrafish resources, now posted on @the-node.bsky.social. While not comprehensive, it gives an assortment of cools tools available to researchers. Feedback would be appreciated! thenode.biologists.com/bioinformati...
thenode.biologists.com
Bioinformatics Bootcamp - Zebrafish Special Edition - the Node
A deep-dive into the many cool (and free) resources available to zebrafish researchers! Disclaimer: This is not a comprehensive list but a list of useful
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 02/05/2025
And just like that we get another #zebrafish surprise ! @pina85.bsky.social work introduces the Inferior Vena Cava vascular remodelling in zebrafish 🦓🐟 Congratulations to all the team for this beautiful story 👏🏻🍾
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 25/04/2025
And that is a wrap! Great success of the first European #Lymphatic Symposium Next one: Budapest 2027
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 04/04/2025
Axillary lymphoid organ in #zebrafish 🤩 rupress.org/jem/article/...
rupress.org
The axillary lymphoid organ is an external, experimentally accessible immune organ in the zebrafish
This work describes a previously uncharacterized external, experimentally accessible secondary lymphoid organ in the zebrafish located above the pectoral f
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 04/03/2025
Do not miss it! ⬇️ @ivanbassi.bsky.social will present his latest project 🐟 #zebrafish
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Reposted by Laura Gutiérrez-Miranda
Kaska Koltowska @lymphaticslab.bsky.social · 10/02/2025
🤩 Excited to share our protocol for computationally averaging confocal images of zebrafish lymphatic vessels to identify phenotypes! 🐟🔬 Check it out in Star Protocols 👉 star-protocols.cell.com/protocols/4030 #Zebrafish #Microscopy #StarProtocols
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 06/02/2025
Not sure exactly what is going on but I have also received this message today at times where traffic should be rather low 😅 So just to be on the safe side here...Does anybody know if there is a mirror page or alternatives in case one of these days NCBI page is gone? 💨
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 28/01/2025
Generation of functional oocytes from male mice🤯 www.nature.com/articles/s41...
nature.com
Generation of functional oocytes from male mice in vitro - Nature
Mouse induced pluripotent stem cells derived from differentiated fibroblasts could be converted from male (XY) to female (XX), resulting in cells that could form oocytes and give rise to offspring aft...
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Reposted by Laura Gutiérrez-Miranda
Zebrafish Rock! @zebrafishrock.bsky.social · 27/01/2025
Useful new tool, for those finterested!
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 13/01/2025
The first oncology clinical trial using #zebrafish avatars will start this month in Portugal. It is definitely not an easy task. But if it works, it will be a great predictive tool 💪🏻 Good luck! www.science.org/content/arti...
science.org
Fish implanted with tumor cells could help oncologists quickly personalize cancer treatments
The first clinical trial of zebrafish embryos acting as cancer “avatars” will start soon
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 11/01/2025
www.nature.com/articles/s41...
nature.com
Repurposing of a gill gene regulatory program for outer ear evolution - Nature
Nature - Repurposing of a gill gene regulatory program for outer ear evolution
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 04/01/2025
www.nature.com/articles/s44...
nature.com
Direct specification of lymphatic endothelium from mesenchymal progenitors - Nature Cardiovascular Research
Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal...
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 02/01/2025
The only #resolution I want for the new year 😅 www.biorxiv.org/content/10.1... #microscopy
biorxiv.org
Deep-Tissue Spatial Omics: Imaging Whole-Embryo Transcriptomics and Subcellular Structures at High Spatial Resolution
The inherent limitations of fluorescence microscopy, notably the restricted number of color channels, have long constrained comprehensive spatial analysis in biological specimens. Here, we introduce c...
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 26/12/2024
I remember doing the ant maze as a lab activity few years ago...and with no communication among the members allowed...it was not so easy 😅 www.pnas.org/doi/10.1073/...
pnas.org
Comparing cooperative geometric puzzle solving in ants versus humans | PNAS
Biological ensembles use collective intelligence to tackle challenges together, but suboptimal coordination can undermine the effectiveness of grou...
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Reposted by Laura Gutiérrez-Miranda
Journal of Cell Science @jcellsci.bsky.social · 16/12/2024
Aanandita Kothurkar, @colinchulab.bsky.social, Ryan MacDonald and colleagues @ucleye.bsky.social apply IBEX to simultaneously identify all the major retinal cell types. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...
Figure showing that IBEX can be used to simultaneously label all major retinal types in zebrafish embryos, including confocal images and schematics indicating the labelled cell types. The confocal images show zebrafish retinas labelled with DAPI and 11 different markers: Ribeye-A (dark blue), carbonic anhydrase (CA1, purple), glutamine synthetase (GS, red), PKC-β (green), Zrf-1 (cyan), HuC/D (orange), GFP transgene (yellow), calbindin (CalB, magenta), peripherin-2 (PRPH2, light blue), GNAT2 (orange) and RLBP1 (pink).
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bioRxivpreprint @biorxivpreprint.bsky.social · 06/12/2024
Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock-ins www.biorxiv.org/content/10.1101/202…
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Reposted by Laura Gutiérrez-Miranda
Zebrafish Rock! @zebrafishrock.bsky.social · 02/12/2024
Help support ZFIN and other MODs by signing this open letter 🙏 🧪
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Reposted by Laura Gutiérrez-Miranda
Development @dev-journal.bsky.social · 30/11/2024
Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration Read this Research Article by Sierra Duca, Yu Xia, Michael R. M. Harrison, Jingli Cao and colleagues: buff.ly/49hhwIf
Figure 1 (A) Larval expression of vegfc:EGFP (green) and kdrl:DsRed (magenta) lines in a 2 dpf live fish. Scale bar: 200 µm. (B) Confocal images showing vegfc:EGFP (green) and kdrl:DsRed (magenta) expression in the trunk at 2 dpf. A single-channel image of vegfc:EGFP expression is shown in grayscale on the right. Scale bar: 100 µm. (C,D) Whole-mount images (maximum projections of z-stacks) of the ventricular surface showing expression of vegfc:EGFP (green) and flt1:tdTomato (magenta) at 5 wpf (C) or 8-9 wpf (D). Single-channel images of vegfc:EGFP expression are shown in grayscale on the right. The framed regions are enlarged beneath. The arrows indicate EGFP+tdTpmato+ arteries. Scale bars: 100 µm.
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 26/11/2024
New study on clonal fate during mouse #embryogenesis using in vivo lineage tracing+ deep learning 🤯👏🏻👏🏻
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Reposted by Laura Gutiérrez-Miranda
Vishal Mohanakrishnan @vishalmkrishnan.bsky.social · 19/11/2024
Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". 🦴🔬😍 Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology. www.nature.com/articles/s41...
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 22/11/2024
Cell division is dispensable for cell differentiation during early development although it delays the differentiation rate of some cell types ⏳. www.nature.com/articles/s41...
nature.com
Cell state transitions are decoupled from cell division during early embryo development - Nature Cell Biology
Kukreja et al. show that blocking cell division in zebrafish does not affect differentiation of major cell types during gastrulation and segmentation, but it does decelerate differentiation of particu...
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 21/11/2024
Vascular Thanksgiving 🙏🏻 www.nature.com/articles/s41...
nature.com
An organotypic atlas of human vascular cells - Nature Medicine
A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 19/11/2024
The fat remembers: a scientific explanation to the yo-yo effect 🪀
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Reposted by Laura Gutiérrez-Miranda
The Company of Biologists @biologists.bsky.social · 19/11/2024
Are you an #ECR who would like to attend a #microscopy or #bioimageanalysis training course in the next ~6 months but don't have sufficient funding, check to see if you are eligible for our JCS-FocalPlane Training Grant. Next deadline: 22 November 2024 www.biologists.com/grants/jcs-f...
Microscopy Training Grants
Supporting microscopy training for early-career researchers in cell biology 

Apply for a grant of up to £1000

Journal of Cell Science FocalPlane
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Reposted by Laura Gutiérrez-Miranda
Zebrafish Rock! @zebrafishrock.bsky.social · 18/11/2024
#ZebrafishFunFacts: While Kimmel et al. (1995) famously standardized the embryonic development of #zebrafish, Parichy et al. (2009) takes it one step further with characterizing postembryonic zebrafish. They establish Standard Length (SL) as measure of developmental progress rather than age. 🧪
External features of developing larvae and internal ossification of the same individuals revealed by calcein staining. Larvae are not to scale. Taken from Parichy et al. 2009 in Developmental Dynamics
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Reposted by Laura Gutiérrez-Miranda
Itai Yanai @itaiyanai.bsky.social · 15/11/2024
If you're just coming in from Twitter, a great way to reconnect with your community is to find the people you were following there with the Sky Follower Bridge. It works really well! www.sky-follower-bridge.dev
sky-follower-bridge.dev
Sky Follower Bridge
Instantly find and follow the same users from your 𝕏 followers on Bluesky
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 14/11/2024
Shout out to @zebrafishrock.bsky.social for making the migration to this new place so smooth. The starter packs to find all the #zebrafish folks are chef's kiss 🙏🏻
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Laura Gutiérrez-Miranda @lgutimiranda.bsky.social · 14/11/2024
Alright, here we go again. Interested in #microscopy #zebrafish #vascular #lymphatics and #stemcells 🔬+🐟+ 🩸
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