Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific seq…

The Review discusses recent advances in single-molecule orientation and localization microscopy (SMOLM) along with remaining challenges and promises for future developments of the field.

In the proposed FY26 budget, programs that help Americans live safer, healthier, longer lives are on the chopping block.

Computational and experimental studies of drug resistance evolution give insights into why some bacteria become resistant.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Optica is the leading society in optics and photonics. Quality information and inspiring interactions through publications, meetings, and membership.

Researchers at academic institutions nationwide say that U.S. science is being dismantled.

We prove that it is impossible to distinguish two spatially coinciding fluorescent molecules from a single rotating molecule using polarization-sensitive imaging, even if one modulates the polarizatio...

Matthew Lew and Yiyang Chen developed a new method to improve precision in molecular imaging

Experiments confirm the prediction that fluid-like biomolecular condensates are defined by spatially inhomogeneous organization of the underlying molecules.

The 2025 Gordon Research Conference on Label-Free Single Molecule Sensing will be held in Easton, Massachusetts. Apply today to reserve your spot.

In the USA, the Trump administration has signed executive orders that impose censorship on key areas of scientific research, strip government scientists of their jobs and reduce federal funding for sc...

‘Paper mills’ are contaminating the world’s scholarly output with fake papers that hinder research. Lifesaving biomedical fields are especially hard hit.

A multi-view reflector microscope based on polarization modulation and pupil splitting enables single-molecule orientation-localization microscopy with precisions of 10.9 nm and 2.0°.

Combining localization and polarization microscopy can yield detailed insights into subcellular structures. POLCAM uses a polarization camera and wide-field microscopy for rapid measurement of super-r...

Amyloid-beta (A{beta}42) aggregates are characteristic signatures of Alzheimer's disease, but probin