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Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

The technology is genuinely useful for scientific discovery, but its applications are less dramatic than you might think.

Enantioselective amine-catalyzed conjugate additions of aldehydes to oxetane- and azetidine-containing nitroolefins afford γ-nitroaldehydes as key building blocks en route to spirocyclic oxetane/azetidine-pyrrolidines. The study provided insights into the stability and reactivity of these β,β-disubstituted nitroolefins and enabled the enantioselective synthesis of chiral oxetanes and azetidines in moderate-to-high yields and enantioselectivities. This approach expands synthetic access to medicinally relevant scaffolds and broadens the scope of enantioselective organocatalytic transformations.

Fluorescently labeled collagen model peptides (CMPs) are emerging as valuable diagnostic tools for fibrosis and tissue repair. We show that fluorophores markedly impact the folding behavior of CMPs a...

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

Selective amino acid receptors that operate in aqueous media are of interest for potential diagnostic and sensing applications. Here, the authors report glucose-derived photoswitchable receptors based...

SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...

Nature - Discovery and engineering of the antibody response to a prominent skin commensal