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Thomä lab

@labthoma.bsky.social
367 followers 256 following 11 posts

We are a structural biology lab located at EPFL in Lausanne www.epfl.ch/labs/thoma-lab

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Thomä lab @labthoma.bsky.social · 30/09/2026
It has been a real pleasure having Pius in the lab and watching this project come together. A very well-deserved milestone — congratulations, Pius! We’ll miss having you around and can’t wait to see what comes next. 🎓🥂
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Thomä lab @labthoma.bsky.social · 30/09/2026
A highlight of Pius’ work was helping uncover new ways to find molecular glues — matching proteins with druggable surfaces and revealing interactions that can be exploited to redirect cellular machinery. Fantastic work, recently published in Nature Biotechnology. 🧬🔬
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Thomä lab @labthoma.bsky.social · 30/09/2026
Huge congratulations to Dr. Pius Galli on successfully defending his PhD at @biozentrum.unibas.ch! 🎉👏 Halfway through his PhD, Pius moved from FMI @fmiscience.bsky.social in Basel to EPFL, where he completed the final part of his research.
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Reposted by Thomä lab
Joy Jeongyoon Choi @joyjoychoi.bsky.social · 16/09/2026
I'm giving a seminar to present this work at EPFL @epflimaging.bsky.social, hosted by @beatfierz.bsky.social and @labthoma.bsky.social. Please come by if you're around campus on Tue 22nd Sept, 4:15pm (details: memento.epfl.ch/event/chroma...).
memento.epfl.ch
Chromatin structure of the inactive X chromosome revealed by in situ cryo-electron tomography - EPFL
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Thomä lab @labthoma.bsky.social · 13/08/2026
We focused on CRL4CRBN here, but expect the approach to be readily adaptable to other E3 ligases and, more broadly, to induced-proximity applications beyond targeted protein degradation.
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Thomä lab @labthoma.bsky.social · 13/08/2026
Pairing this with a focused MGD compound screen, we show these latent interactors are privileged starting points for new degrader development—adding a scalable, rational entry point alongside the field's growing computational and proteomic toolkit.
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Thomä lab @labthoma.bsky.social · 13/08/2026
In our latest paper with the Correia lab, led by @piusgalli.bsky.social and Shuhao Xiao, we built a scalable pipeline combining AI-driven surface mimicry (MaSIF-mimicry) with an interaction assay (GluePCA) to map the latent MGD-induced CRBN interactome: proteins that bind but aren't (yet) degraded.
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Thomä lab @labthoma.bsky.social · 13/08/2026
tinyurl.com/24dz4yfe #TargetedProteinDegradation, #MolecularGlue, #DrugDiscovery, #EPFL @epfllibrary.bsky.social
tinyurl.com
Proteome-wide identification of the druggable CRBN interactome - Nature Biotechnology
The latent interactions of molecular glue degraders are identified proteome-wide.
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Thomä lab @labthoma.bsky.social · 13/08/2026
Congrats to Pius, Shuhao, and the team! Check out our latest publication: Molecular glue degraders (MGDs) like lenalidomide have transformed multiple myeloma treatment by inducing degradation of non-native substrates via the CRL4CRBN E3 ligase—but which proteins can they actually reach?
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FMI science @fmiscience.bsky.social · 31/07/2025
Our cells pack DNA into tiny bundles that hide important parts. Researchers at the FMI and EPFL found this packing affects how the cancer-fighting protein p53 works, revealing new insights into cancer. www.fmi.ch/news-events/...
fmi.ch
How DNA packaging controls the “genome’s guardian”
Our cells tightly pack DNA into structures called nucleosomes, which protect DNA but also hide important sites. The key cancer-fighting protein p53 can still access these hidden sites, especially at n...
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Thomä lab @labthoma.bsky.social · 31/07/2025
Stay tuned for @csandate.bsky.social's thread to come! @deyasinic.bsky.social Thanks for all the support! #EPFL @fmiscience.bsky.social @erc.europa.eu @snsf.ch @krebsliga.bsky.social
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Thomä lab @labthoma.bsky.social · 31/07/2025
Congrats to all the authors on our latest work! We reveal how p53 interacts with chromatin and show, via ubiquitin-related factors USP7 and E6-E6AP, that only specific cofactors can co-reside on nucleosomes together with p53. tinyurl.com/2feuezvj @csandate.bsky.social @deyasinic.bsky.social
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Thomä lab @labthoma.bsky.social · 08/05/2025
📝 🚨 Review alert from the Thomä Lab @alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action. tinyurl.com/mpmbuuky
tinyurl.com
Primed for degradation: How weak protein interactions enable molecular glue degraders
Molecular glues are small drug-like molecules that induce de novo protein–protein interactions or facilitate pre-existing weak interactions between pr…
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