Author summary The human genome is peppered with repeated segments that are located at sites both nearby and distant from the original, ancestral segments. These Copy Number Variants, or CNVs, appear ...

Here the authors show that collapse of single replication forks causes recombination, end fusions or degradation but does not restart DNA synthesis. In contrast, collapse of convergent forks completes...

Agency acknowledges young investigators are losing out as result of multiyear funding policy imposed by White House

Cellular proliferation relies on the successful coordination and completion of genome replication and segregation. To help achieve this, many bacteria utilize regulatory pathways that ensure DNA repli...

Nature Communications - Transcription–replication conflicts can threaten genome stability. Here, the authors show that RNA polymerase II (Pol II) is a stronger roadblock to a DNA fork in the...