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Kobe652

@kobe652.bsky.social
428 followers 878 following 280 posts

Born in #Lyon, #France. Postgrad #MIT. Lived in #Kobe, #Japan. #pwME, #MECFS since 2009, #PEM, #HSP #leagueoflegends #wildrift

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Reposted by Kobe652
Charles Gaba ✡️ @charlesgaba.com · 19h
#FunFact: Yes, it's now possible to drive a standard, mainstream EV from New York to Los Angeles in a reasonable amount of time without getting stranded with a dead battery and WITHOUT having to use a Tesla station!
Map of mainland U.S. with EV route from NYC to LA
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Reposted by Kobe652
Tom Kindlon @tomkindlon.bsky.social · 20h
He is also on IG with the same username #MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #meawareness #mecfsawareness
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Tom Kindlon @tomkindlon.bsky.social · 05/10/2026
🧵 Ultimately, fatigue in ME/CFS shrinks lives so severely it often takes a devastating toll on mental health. This impact is unsurprising given the immense loss of careers, relationships, hobbies, & independence. tinyurl.com/fatigueimpac... #mecfs #pwME #cfs #fatigue #ChronicFatigueSyndrome 1/
Impact of fatigue in ME/CFS 
"I lost my job, I don't leave my home. I miss appointments. I can't enjoy hobbies." 
Response from ME Research UK Symptom Saturday Fatigue Survey 
IC% RESEA,CH U K 
INFORM. INFLUENCE. INVEST.
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Kobe652 @kobe652.bsky.social · 06/10/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
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Reposted by Kobe652
Tom Kindlon @tomkindlon.bsky.social · 04/10/2026
New from France Interesting long Covid research where all participants satisfy ME/CFS criteria Evidence for transcriptomic changes impacting muscle contraction in patients with post-acute COVID-19 syndrome www.sciencedirect.com/science/arti... #LongCovid #MEcfs #PwME #CFS #postcovid #postcovid19
Post-acute COVID-19 syndrome (PACS) overlaps with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) but, due to frequent muscle pain and exertional intolerance, neuromuscular disorders are often suspected. We report the results of a comprehensive neuromuscular evaluation in 27 PACS patients (22F/5M; median age 41 ys). All patients developed chronic fatigue (>6 months), post-exertional malaise, and cognitive impairment, with muscle pain in 88% but no neuromuscular deficits at clinical examination. 18/27 patients were unable to work. All patients fulfilled established ME/CFS diagnostic criteria (CDC 1994, ICC 2011, Inst Medicine 2015, NICE 2021). Electrophysiological studies and CK levels were normal. Brain 18FDG-PET/MRI (14/27) showed posterior hypometabolism in 8/14. Muscle biopsy (7/27) showed moderate dysimmune changes in 2/7. Exploratory transcriptomic analyses performed in muscle biopsies from PACS patients and pre-COVID controls unveiled in PACS differentially expressed genes in the cytokine and autophagy pathways. Interestingly, other genes were also differentially expressed in pathways affecting actin, the cytoskeleton, and contraction. Indeed, we found upregulated genes involved in the troponin-tropomyosin complex, a key regulator of muscle contraction through calcium binding. We also found downregulated genes involved in the formation and stabilization of actin bundles at sarcomere Z discs and in mechanical signaling. These findings indicate that PACS patients with prominent muscular symptoms do not exhibit overt neuromuscular involvement on standard investigations but may show subtle myopathic or dysimmune changes and central metabolic alterations. At the transcriptomic level, the data show an impact on key pathways involved in contraction. The overlap with ME/CFS highlights the importance of careful differential diagnosis and suggests a complex pathophysiology beyond a basic muscle disease.
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Kobe652 @kobe652.bsky.social · 04/10/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
000
Reposted by Kobe652
worm @rfksbrainworm.bsky.social · 02/10/2026
If you ever wondered why visible light is those particular wavelengths, it's because life evolved to see in the narrow range where water is transparent
Diagram of absorption of emf by water. There's a gap right that dips in the 500 nm range
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Reposted by Kobe652
Chronic Illness Humor @chronicillness.bsky.social · 02/10/2026
Artist: @ChronicallyMeh on Insta
illustration showing a person with long, dark curly hair wearing a pink shirt and blue pants lying completely flat on the floor, seemingly melted into a puddle.

A speech bubble from off-screen asks, "Are you ok?"

The person on the floor replies in a speech bubble, "This is my baseline". Near their head is a small watermark logo that reads "CHRONICALLY MEH".
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Reposted by Kobe652
John Hanger @jrfhanger.bsky.social · 02/10/2026
Good morning with good news: France's September Full-EV sales reach 42% of auto sales. Full-EV sales skyrocket 108% in September! Full-EV and Plug-In Hybrid were 48% of auto sales! Petrol-only cars were just 13% and diesel collapsed to 2.4%! www.aaa-data.fr/actualites/i... #energysky
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Massimo (mirror) @rainmaker1973-m.bsky.social · 02/10/2026
A simple carpentry trick Original post
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Denis - The COVID Info Guy @thecovidinfoguy.bsky.social · 01/10/2026
"COVID fatigue linked to reduced brain blood flow" Brain scans found lower overall cerebral blood flow in people with Long COVID, especially in regions involved in attention, sensory processing and cognitive control. Lower blood flow was also linked to slower reaction times and concentration.
medicalxpress.com
COVID fatigue linked to reduced brain blood flow
Playing with your children or meeting a friend for coffee are everyday activities that many people move between without giving much thought to how much mental or physical energy they take.
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Kobe652 @kobe652.bsky.social · 29/09/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
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Reposted by Kobe652
Tom Kindlon @tomkindlon.bsky.social · 27/09/2026
From @meresearchuk.bsky.social In the fourth deep-dive of our weekly Symptom Saturday series, we explore debilitating fatigue in ME/CFS – including lived experience, research insights, related diagnostic delays, and management. Read more: www.meresearch.org.uk/fatigue-in-m... #MEcfs #CFS #PwME
FATIGUE IN ME/CFS 
Fatigue in ME/CFS is not "just tiredness", it is a debilitating, unrelenting exhaustion that is inadequately relieved by rest and drastically reduces one's capacity to carry out daily activities. 
• ME/CFS-related research highlights: • Low heart rate variability linked to higher fatigue levels. • Potential functional/structural brain differences, such as in prefrontal cortex, related to fatigue. • A study showed that whilst the nature of fatigue across different chronic disease cohorts was similar, people with ME/CFS had much higher levels of total fatigue than any of the other groups. Although the studies have limitations, they are a starting point for further research. 

• e • 
INFORM. INFLUENCE. INVEST. Full overview and references at [tinyurl.com/fatiguesymptomsat] 
ChiPlitA RESEARCH UK SCO36942
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Tom Kindlon @tomkindlon.bsky.social · 27/09/2026
From @meresearchuk.bsky.social Exciting research funded by ME Research UK was showcased at the ISLC-PAIS 2026 conference! Discover more about the presentations here: tinyurl.com/246rj47b #mecfs #cfs #pwme #longcovid
RESEARCH UK 
ISLC-PAIS 2026: ME Research UK-funded research highlights 
ME Research UK-funded research presented at ISLC-PAIS 2026 covered topics including: 

Muscle abnormalities 

Gene regulation 
Fat metabolism Cellular waste Q=1, • •• • e _ 

Blood vessel Post Subtle exertional changes in abnormalities malaise brain tissue 
Together, the studies illustrated the range of biological differences being identified in ME/CFS, and in long COVID, while also highlighting important questions for future research. 
INFORM. INFLUENCE. INVEST. 
SCO36942
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Tom Kindlon @tomkindlon.bsky.social · 27/09/2026
25 adolescents with ME/CFS found to have slower information-processing speeds, poorer sleep, reduced quality of life, and poorer mental wellbeing compared with 25 healthy controls of the same age. Read more: bit.ly/4dUz7sZ Link to research paper: bit.ly/4rzVKc8 #mecfs #cfs #pwme #cfsme
ME/CFS in Adolescence: Effects on cognition and wellbeing 
25 young people with mild or moderate ME/CFS aged 12 to 19 years were compared with 25 healthy controls of the same age. 
Results showed that those with ME/CFS had: 

Greater symptom burden including poorer sleep and reduced quality of life 
Slower processing speeds 
'? 

Issues with attention and working memory 
Reduced `psychosocial wellbeing' 
Note: This study used a small sample size and did not include those with more severe froms of the disease. 
4 
INFORM. INFLUENCE. INVEST. 
SCO36942 
Chau, T., Josev, E. K., Scheinberg, A., at al. J. Paediatr. Child Health. 2026; 1-13.
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Reposted by Kobe652
Tom Kindlon @tomkindlon.bsky.social · 28/09/2026
“I look fine, but dealing with chronic illness is my full-time job” (Pittsburgh's Public Source) www.publicsource.org/pots-long-co... First person account about coping with chronic illness triggered by COVID infection. #LongCovid #invisibleillness #hiddenillness #chronicillness
publicsource.org
I look fine, but dealing with chronic illness is my full-time job
Jennifer McCalla doesn't look sick, but living with long COVID and POTS is a full-time job. She writes about invisible illness and the fight to be believed.
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Kobe652 @kobe652.bsky.social · 28/09/2026
Also pleasure. Driving an EV is another experience, and a great one.
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Kobe652 @kobe652.bsky.social · 25/09/2026
Same but I fell in love with my new EV.
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Tom Kindlon @tomkindlon.bsky.social · 24/09/2026
(Queensland, Australia) "Help Us Research Chronic Neuroinflammation in ME/CFS" More information here (third item) mecfs.org.au/get-involved... The QR code goes here: www.unisc.edu.au/thompson-ins... #MEcfs #PwME #CFS #MyalgicEncephalomyelitis #ChronicFatigueSyndrome
UniSC
Australia
Thompson Institute
Help Us Research Chronic Neuroinflammation in ME/CFS
We are seeking adults aged 18-65 with Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) to assist us to investigate chronic neuroinflammation in ME/CFS.
You could be eligible if:
• You are aged between 18-65 (with ME/CFS).
• Can communicate in English.
Have no neurological or active psychiatric illnesses.
As a research participant, you would take part in:
• At your own pace, questionnaires to assess different aspects of mental and physical health status.
•
A physical assessment.
One magnetic resonance imaging (MRI) scan (50 minutes scanning time plus preparation).
One blood and saliva sample collection.
Participants with fatigue conditions will also take part in:
Two clinical telehealth interviews with two specialists. Each interview will be scheduled for 30-45 minutes.
To express your interest or learn more,
please contact:
Anya, Research Coordinator
Email: cfs@usc.edu.au
We appreciate your time and effort, so participants will be gifted $50.00 AUD for their participation and will receive a copy of their brain scan.
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Reposted by Kobe652
Tom Kindlon @tomkindlon.bsky.social · 24/09/2026
As many of you already know, @georgemonbiot.bsky.social has published another hard-hitting article on ME in the Guardian today. Great to see such coverage, especially as the Guardian published some rubbish by others before www.theguardian.com/commentisfre... #MEcfs #PwME #MyalgicEncephalomyelitis
Opinion
ME / Chronic fatigue syndrome
Abandoned, dismissed and gaslighted: there is no excuse for the way ME sufferers have been betrayed
George Monbiot
George Monbiot
Changes in guidance and science seem to have little impact on millions of devastated lives. It’s a shocking social crisis playing out behind closed doors
Thu 24 Sep 2026 01.00 EDT
Somebody sitting on a bed looking at a wall with a display of negative past medical experiences
 Illustration: Bill Bragg/The Guardian
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Reposted by Kobe652
James Murray @james-bg.bsky.social · 23/09/2026
Fascinating new figures confirming old EVs with a lot of miles on the clock are much more reliable than their petrol and diesel equivalents. www.businessgreen.com/news/4536166...
businessgreen.com
Study: High mileage EVs more reliable than petrol equivalents
Analysis of 47.4 million MOTs finds electric cars are around 25 per cent less likely to fail than petrol models as mileage climbs
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Kobe652 @kobe652.bsky.social · 23/09/2026
Why Did Japan Alone Keep Two Layers of Kanji Readings? flip.it/JDh_SR
flip.it
Why Did Japan Alone Keep Two Layers of Kanji Readings? - Unseen Japan
Languages can be stubborn things. You can see this clearly in Japanese, where multiple layers of kanji pronunciation exist to this day.
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Reposted by Kobe652
Tom Kindlon @tomkindlon.bsky.social · 21/09/2026
Zoe Sirotiak – a person with ME/CFS, researcher, and physical therapist – has published a paper on how the societal expectation for people who are unwell to “get better” can create harm for people with chronic diseases, like ME/CFS. Read more: bit.ly/4irwxOp #mecfs #cfs #pwme
CHow societal expectations of recovery an lead to harm for people with ME/CFS 
Zoe Sirotiak, who lives with ME/CFS and is also a researcher and physical therapist, wrote a paper about how the expectation that people with an illness should get better, return to their normal lives, or grow from the experience can be harmful to people with ME/CFS. 
Notably, this "myth of recovery" can: 

Exclude people who remain ill 


Wrongly Distract from suggest gaps in recovery is research, about attitude healthcare and or effort social support 
INFORM. INFLUENCE. INVEST. RESEARCH UK SC0.942 
Sirotaik Z. Disability & Illness (2026)
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Kobe652 @kobe652.bsky.social · 18/09/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
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Kobe652 @kobe652.bsky.social · 18/09/2026
video.twimg.com/amplify_vide...
video.twimg.com
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Massimo (mirror) @rainmaker1973-m.bsky.social · 18/09/2026
The Strauss-Howe generational theory describes a recurrent cycle of same-aged groups with specific behavior patterns that change every 20 years. This is a visual representation of the concepts in 1997 book 'The Fourth Turning'. [📹 Van Neistat] Original post
video.twimg.com
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Kobe652 @kobe652.bsky.social · 17/09/2026
I hate cars in general. But not my R5.
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Kobe652 @kobe652.bsky.social · 17/09/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
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Kobe652 @kobe652.bsky.social · 17/09/2026
Not that far, really.
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Kobe652 @kobe652.bsky.social · 17/09/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
010
Kobe652 @kobe652.bsky.social · 15/09/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
021
Kobe652 @kobe652.bsky.social · 15/09/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
000
Reposted by Kobe652
Digital Brain @yourdigitalbrain.bsky.social · 15/09/2026
The Vatican formally classified environmental destruction as a direct sin against the Creator, urging millions of believers to embrace ecological protection as a fundamental moral and religious duty. Source: America Magazine.
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Digital Brain @yourdigitalbrain.bsky.social · 12/09/2026
The starting point is De Broglie's wavelength: any material object also behaves like a probability wave of position.
sinapti.ca
Everything You Need to Know to Understand Quantum Mechanics, Without Equations - Sinaptica
In a long video that brings together a decade of episodes, PBS Space Time (Matt O'Dowd's channel, PBS Digital Studios) takes a tour through the central ideas of
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Kobe652 @kobe652.bsky.social · 12/09/2026
No difference
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SARS‑CoV‑2 (COVID-19) @covid19disease.bsky.social · 04/09/2026
www.smithsonianmag.com/innovation/t...
smithsonianmag.com
This High School Student Invented a Filter That Eliminates 96 Percent of Microplastics From Drinking Water
Virginia teenager Mia Heller’s filtration system harnesses the power of ferrofluid, a magnetic oil that binds to microplastics in flowing water
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Dr. Lucky Tran @luckytran.com · 30/08/2026
“Why didn’t scientists warn us?”
Newspaper clipping:

Thr Rodnen & Otamatea Times
WAITEMATA & KAIPARA GAZETTE
PRIOE~10s perannum in adrance
WARKWORTE, WEDNESDAY AUGUST 14, 1912
3d per Copy.
Science Notes and News.
COAL CONSUMPTION AFFECT.
ING CLIMATE.
The furnaces of the world are now
burning about
2,000,000,000 tons of
coal a ycar.
When this is burned,
uniting with oxygen, it adds about 7,000,000,000 tons of carbon dioxide to the atmosphere yearly. This tends to make the air a more effective blanket for the carth and to raise its temperature. The effect may be considerable in a few centuries.
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Libération @liberation.fr · 23/08/2026
🚲 Zones à faibles émissions : «Notre étude est la première à mettre en évidence un effet bénéfique sur le développement des poumons des enfants»  ➡️ Interview : l.liberation.fr/rmG
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Kobe652 @kobe652.bsky.social · 21/08/2026
Conservatism consists of exactly one proposition, to wit:
There must be in-groups whom the law protects but does not bind, alongside out-groups whom the law binds but does not protect.
There is nothing more or else to it, and there never has been, in any place or time. — Frank Wilhoit
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Reposted by Kobe652
Digital Brain @yourdigitalbrain.bsky.social · 18/08/2026
New Zealand granted legal personhood to Te Kāhui Tupua, including Taranaki Maunga and other ancestral mountains. The measure allows their interests to be legally represented and recognizes the Māori cultural and spiritual relationship with these territories.
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Kobe652 @kobe652.bsky.social · 15/08/2026
Truly surprised. Lots of sheep here in Ardèche, France. Nothing like that. For instance: www.ardelaine.fr/home
ardelaine.fr
Ardelaine - Boutique Pure Laine et Site touristique en Ardèche
Ardelaine : SCOP en Ardèche qui fabrique des matelas, couettes, vêtements en pure laine locale et bio depuis 1982. Site touristique, visites, restaurant.
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Kobe652 @kobe652.bsky.social · 11/08/2026
Energy prices, not power prices.
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Kobe652 @kobe652.bsky.social · 11/08/2026
Napoleon 3rd, Hitler…
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Kobe652 @kobe652.bsky.social · 10/08/2026
Long COVID Linked to Lasting Damage in The Brain's Dopamine System flip.it/x17ygG
flip.it
Long COVID Patients Have 18% Fewer Dopamine Nerve Endings, Brain Scans Reveal
COVID-19 can cause brain injuries that are still visible on scans years later in people with neurological symptoms related to long COVID.
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Tom Kindlon @tomkindlon.bsky.social · 08/08/2026
For severe ME day From Mahli Quinn Art's "Severe and very severe ME comic" (link in next comment) #SevereME #SevereMEDay 1/
Image of somebody lying in bed with the following words around them


SEVERE ME.
COGNITIVE ABILITY
SIGNIFICANTLY REDUCED
SENSITIVITY TO
LIGHT/SOUND
MAJORITY OF TIME RECUMBENT
MAY NEED MOBILITY AIDS
MAY NEED HELP WITH ACTIVITIES OF DAILY LIVING
EVEN LIGHT ACTIVIES ONLY TOLERATED FOR SHORT PERIODS
LEAVING HOUSE PROVOKES SIGNIFICANT. PROLONGED SYMPTOM FLARE
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omgisme @omgisme.bsky.social · 07/08/2026
😍
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Kobe652 @kobe652.bsky.social · 08/08/2026
And Obama in 2014, with all due respect for him.
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Kobe652 @kobe652.bsky.social · 08/08/2026
I think we should call the VAR on this.
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Joe Noonan @joenoonan.bsky.social · 07/08/2026
Uruguay, with 3.5 million people, generates 98% of its electricity from renewable sources. The architect of that transformation, Ramón Méndez Galain, put it simply: "The key is not technology; it is institutions. Once the rules are fair and predictable, the system builds itself."
irishexaminer.com
Our solar power model isn't working — there's a fairer way
Solar lease-to-own could unlock Ireland's energy future — Uruguay, the Netherlands and Germany have all made this work with straightforward rules, writes Mary Teehan
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Kobe652 @kobe652.bsky.social · 05/08/2026
That’s 2 questions. But yes, yes.
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