iiinova — where your digital self keeps evolving

KenOliveLab @kenolivelab.bsky.social · 26/09/2026

Excited to welcome over 600 scientists to the 2026 AACR conference on pancreatic cancer in San Diego. An extraordinary exciting time for our field this year with a new FDA approval for metastatic pdac. #aacrpdac

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KenOliveLab @kenolivelab.bsky.social · 26/08/2026

Daraxonrasib is FDA approved for treatment resistant metastatic pancreatic fantastic cancer. I'm so happy.

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KenOliveLab @kenolivelab.bsky.social · 28/06/2026

This is one of the most remarkable stories of technology benefitting society that I've read in years. Anyone looking for a positive read today should check it out. www.nytimes.com/interactive/...

nytimes.com

How Phones Alerted Millions Before Earthquakes Shook Venezuela

Millions of people in Venezuela and surrounding countries received early warning alerts to their phones up to two minutes before back-to-back earthquakes on Wednesday.

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KenOliveLab @kenolivelab.bsky.social · 24/06/2026

I fell behind on posting. Day 4 of #CSHLPDAC26 included lectures by Danni Engle (Model Systems), Laura Wood (early lesions), Bryson Katonah (epidemiology), and me (mouse models and translational research).

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KenOliveLab @kenolivelab.bsky.social · 21/06/2026

Day 3 of #CSHLPDAC2026! Cancer immunology day, with a tag-team lineup from Stephanie Dougan and Kate Byrne.

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KenOliveLab @kenolivelab.bsky.social · 20/06/2026

I just mis-clicked and hit Accept on a paper review that I meant to decline. 🤦‍♂️ Sigh.

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KenOliveLab @kenolivelab.bsky.social · 20/06/2026

Day 2 of the CSHL PDAC. Marina Pasca di Magliano kicks off with an intro to the TME, Nina Steele discusses endothelial cells, @marasherman.bsky.social covers nerves, and @tme-caf-ecm.bsky.social explains the ECM. Capped off by tumor plasticity and subtypes by @hccvpdac.bsky.social.

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KenOliveLab @kenolivelab.bsky.social · 19/06/2026

Really excited to welcome this year's class of students to the 2026 Cold Spring Harbor course on Pancreatic Cancer! Kicking off the course with a day of clinical education from @anirbanmaitra.bsky.social, @filbednar.bsky.social , Andy Aguirre, @manciaslab.bsky.social & @benstanger01.bsky.social.

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KenOliveLab @kenolivelab.bsky.social · 31/05/2026

My lab had a watch party for Brian Wolpin's plenary lecture at ASCO reporting the results of the RASolute 302 Phase 3 trial of daraxonrasib in previously-treated metastatic PDAC. TWO standing ovations. So incredibly excited to see these results.

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KenOliveLab @kenolivelab.bsky.social · 26/05/2026

I swear some of my lab members like to torture me by holding off telling me about their results. When I was a student, I had NO CHILL - the second I had a result, I wanted to tell everyone about it. Now my students are like "oh, I'll tell you about that next week in lab meeting". WTF!?!?!

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KenOliveLab @kenolivelab.bsky.social · 20/04/2026

Super proud of my postdoc, Alvaro Curiel-Garcia @alvarocuriel.bsky.social for his Rising Star lecture at #AACR26. Alvaro has a Nature Genetics cofirst author paper in press, and another 1st author manuscript that is in revision, also at Nature Genetics. He's on the job market folks!

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KenOliveLab @kenolivelab.bsky.social · 13/04/2026

Daraxonrasib median OS 13.2 months vs. 6.7 for chemotherapy. Phase 3 randomized controlled trial. I'm so happy. ir.revmed.com/news-release...

ir.revmed.com

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AndreaVentura @andreaventura.bsky.social · 18/03/2026

We are seeking a highly motivated scientist with expertise in mouse embryo manipulation and the generation of genetically engineered mouse models. This is a permanent position with competitive compensation. Contact me via direct message if interested. Please share!

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Columbia Department of Medicine @cuimcmedicinedept.bsky.social · 30/01/2026

Did you know pancreatic tumors plan their travels? Learn more about this fascinating new discovery: www.cancer.columbia.edu/news/pancrea...

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Jenna Norton @jenna-m-norton.bsky.social · 20/01/2026

The language on multiyear funding (MYF) is ineffective. Final bill anchors MYF to 2025 instead of 2024. This means MYF will likely continue at the same rate we saw last year, where NCI's payline from ~10% to 4%. This is incredibly harmful to the US research workforce - especially early career.

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Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 22/01/2026

🧪IMPORTANT! This graphic explains how science all over the US is funded. Congress approved a 2% increase in the #NIH budget for FY 26. Buried in the bill- Shift of ~40% of grants to MYF. This will still result in a 35% DECREASE in the NUMBER of grants funded per yr. Russel Vought is behind this.

Graphic helps visualize how MYF funds FEWER grants despite the increase in budget approval by Congress.

https://www.researchamerica.org/wp-content/uploads/2025/11/ACT-for-NIH-Multi-Year-Funding-One-Pager_October-2025.pdf

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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 20/01/2026

The NIH's MYF policy in 2025 resulted in 4000 fewer grants and fellowships that touched every area of biology and medicine; continuing it in 2026 would be disastrous for science, technology and health in the United States 🧪 www.nytimes.com/interactive/...

nytimes.com

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine

A quiet policy change means the government is making fewer bets on long-term science.

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David Ho @davidho.bsky.social · 20/01/2026

This is the most astonishing graph of what the Trump regime has done to US science. They have destroyed the federal science workforce across the board. The negative impacts on Americans will be felt for generations, and the US might never be the same again. www.nature.com/immersive/d4...

This line graph illustrates the percentage change in agency staff levels from the previous year for nine major U.S. federal scientific and health organizations between the fiscal years 2016 and 2025. The agencies tracked include the CDC, Department of Energy, EPA, FDA, NASA, NIH, NIST, NOAA, and NSF. For the majority of the timeline between 2016 and 2023, the agencies show relatively stable fluctuations, generally staying within a range of +5% to -5% change per year. However, there is a dramatic and uniform plummet starting in the 2024–25 period. Every agency depicted shows a sharp downward trajectory, with staffing losses ranging from approximately -15% to over -25%. The Environmental Protection Agency (EPA) shows the most significant decline, dropping to roughly -26%, while the National Institute of Standards and Technology (NIST) shows the least severe but still substantial drop at approximately -15%.

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KenOliveLab @kenolivelab.bsky.social · 19/01/2026

It is a PROBLEM that the new MANDATORY ScienCV platform does not (as far as I can tell) enable one to indicate co-first or co-senior authorship in your bibliography. This is a massive disincentive to collaborative science and it needs to be fixed.

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KenOliveLab @kenolivelab.bsky.social · 06/01/2026

NIH - you can ONLY use our proprietary system to generate your biosketch. Simply typing it up isn't allowed. Ready GO! Everyone has to start using it RIGHT NOW! Also NIH - what do you mean they ScienCV is barely functional and hangs every time you use it? no idea what your talking about...

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KenOliveLab @kenolivelab.bsky.social · 13/10/2025

Dear journal editors, what do we think about including summary figures in a cover letter? I've never done this, but a co-author wants to include one for our latest manuscript. Helpful in illustrating the case? Weird and gauche? What say ye?

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KenOliveLab @kenolivelab.bsky.social · 13/06/2025

Finally, a huge thanks to all of our incredible students at #CSHLPDAC25. This was a standout class who leaned into the science, the questions, and... UNO! Look forward to seeing you all at meetings for many years to come!

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KenOliveLab @kenolivelab.bsky.social · 13/06/2025

So, I dropped the ball in my #CSHLPDAC25 posts. Huge shout out to all of the instructors I didn't get to highlight with photos, including: Ingunn Stromnes (Immunology I), David DeNardo (Immunology II), Bryson Katona (Epidemiology and Early Detection)...

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KenOliveLab @kenolivelab.bsky.social · 06/06/2025

Computational biologist extraordinaire Dr. Elana Fertig ‪@fertiglab.bsky.social‬ asks "what's your QUESTION?" Please be nice to your friendly neighborhood computational scientist!

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KenOliveLab @kenolivelab.bsky.social · 05/06/2025

In our second talk on cancer-associated fibroblasts, Dr. Mara Sherman from MSKCC digs into the functional relationships of CAFs with other cells in pancreatic cancer at #CSHLPDAC25.

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KenOliveLab @kenolivelab.bsky.social · 05/06/2025

Next up, course director (and fellow Hedgehog pathway afficianado) Dr. Marina Pasca de Magliano from UMich gave the first of two lectures on fibroblasts in the pancreas, preneoplasia, and PDAC.

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KenOliveLab @kenolivelab.bsky.social · 05/06/2025

Dr. Laura Wood gave a fascinating lecture on precursor lesions and the spectacular 3D pathology tools that she and her extended team at JHU have developed to quantify pancreatic pathology.

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KenOliveLab @kenolivelab.bsky.social · 05/06/2025

Kicking off the morning with end-to-end coverage of gastroenterology for #PDAC, from the inimitable Dr. Ben Stanger @benstanger01.bsky.social! #CSHLPDAC25

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KenOliveLab @kenolivelab.bsky.social · 04/06/2025

Radiology and Radiation Oncology - Dr. Eugene Koay from MD Anderson tells us they both are RAD!

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KenOliveLab @kenolivelab.bsky.social · 04/06/2025

Now a masterclass on the medical oncology of #pdac from Dr. Andrew Aguirre at DFCI, highlighting the coming wave of RAS inhibitors in PDAC. #cshlpdac25

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KenOliveLab @kenolivelab.bsky.social · 04/06/2025

Next up, an overview of pancreatic cancer surgery from suregon-scientist Dr. Fil Bednar ‪@filbednar.bsky.social‬ (a former student in our class!). #cshlpdac25

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KenOliveLab @kenolivelab.bsky.social · 04/06/2025

First up, Dr. Aatur Singhi @pancpathologist.bsky.social‬ at U. Pittsburgh with an overview of pancreatic cancer pathology

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KenOliveLab @kenolivelab.bsky.social · 04/06/2025

Excited to welcome a whole new class of students to the 2025 Cold Spring Harbor course on pancreatic cancer #CSHLPDAC25! This year we have twenty two course instructuors reach to share their expertise on all aspects of PDAC biology, medicine, and research. Ready for an exciting week!

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KenOliveLab @kenolivelab.bsky.social · 15/05/2025

Look what bloomed in my office today! Finally got this one healthy enough to bloom annually.

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KenOliveLab @kenolivelab.bsky.social · 28/04/2025

And now for postdoc #2 at #aacr2025, our very own Dr. Marie Hasselluhn! @columbiacancer.bsky.social

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KenOliveLab @kenolivelab.bsky.social · 28/04/2025

Big day today at #aacr2025! @alvarocuriel.bsky.social is presenting his work on BMAL2, a master regulator of PDAC hypoxic response (poster 2570) and Dr. Marie Hasselluhn is presenting her work on role of CAF/myeloid crosstalk in PDAC immunosuppression in PDAC (poster 1501). Come check them out!

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KenOliveLab @kenolivelab.bsky.social · 25/04/2025

On my way to #aacr2025 in Chicago, can't wait to see my many friends and colleagues who will be there. Please check out posters from my postdocs @alvarocuriel.bsky.social and Marie Hasselluhn!

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KenOliveLab @kenolivelab.bsky.social · 07/03/2025

As I was on my way to the Stand Up For Science rally in NYC, I learned that the US plans to cancel $400M in grants and contracts with Columbia. Let us be clear. This is purely an effort to instill fear and bring American universities to heel. You can be certain Columbia will not be the last.

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KenOliveLab @kenolivelab.bsky.social · 07/03/2025

That's me in the orange at NYC Stand Up For Science. Congrats to the organizers for a fantastic turnout and event! @standupforscience.bsky.social

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KenOliveLab @kenolivelab.bsky.social · 07/03/2025

Standing up for Science in Washington Square Park, #NYC #standupforscience

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KenOliveLab @kenolivelab.bsky.social · 26/02/2025

Someone in one of the labs in my building woke up this morning and chose violence. The cardboard box is slowly crushing over time, creating the leaning tower of mini-fridge. WHY!?!?! (Lab name redacted to protect the guilty...)

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KenOliveLab @kenolivelab.bsky.social · 07/02/2025

Publicly announced today my new roles as assistant dean for graduate curricula at Columbia's Vagelos College of Physicians and Surgeons (VP&S), and Associate Director of the Vagelos Institute for Biomedical Research and Education (VIBRE). Wish me luck balancing science and administration!

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KenOliveLab @kenolivelab.bsky.social · 24/01/2025

Yet another example of how cancelling NIH meetings is impacting research: I have an R01 application that scored right on the cusp of funding. Council meeting is in 4 weeks. The next resubmission date is in 6. If that council meeting is delayed more than 2 weeks, I will face a choice of...

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Aafke Gros @aafkegros.bsky.social · 15/01/2025

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

FIB-SEM dataset visualized with Microscopy Nodes, data from Mocaer et al 2023

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