Thrilled to share that my co-first author paper is now in @NatureGenet!Thanks to Mikko, Pas, Andrea, Ken and all co-authors!! Pancreas cancer is defined by mutant #KRAS, yet most tumor cells show little MAPK activity.Here’s how plastic cell states explain that paradox.
www.nature.com/articles/s41...
nature.com
Developmental and MAPK-responsive transcription factors regulate distinct malignant cell states and associated genetic dependencies in pancreatic cancer - Nature Genetics
The authors apply ARACNe and metaVIPER to published scRNA-seq datasets to characterize pancreatic cancer subtypes, identifying six distinct cell states as well as their mechanistic determinants. Funct...
