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Jess

@jumpinggenomes.bsky.social
29 followers 13 following 7 posts

Mitos, plastids, endosymbiosis, gene transfer, origins of life, tRNAs and all things wonky in mol. evolution 🧬 Postdoc in McCutcheon lab. HHMI Hanna Gray Fellow

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Jess @jumpinggenomes.bsky.social · 11/06/2026
www.pnas.org/doi/epdf/10....
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Jess @jumpinggenomes.bsky.social · 11/06/2026
Whats the minimum number of tRNA genes necessary to decode 20 amino acids? Surprise, its less than 20! Super excited to share this work where we demonstrate that the bidirectional expression of some mitochondrial genes gives rise to two different tRNAs, capable of decoding different amino acids🪞tRNA
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Iain Johnston @mitomaths.bsky.social · 13/02/2026
Perhaps... how life started?! www.science.org/doi/10.1126/...
science.org
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
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Piotr Lukasik @sympiotr.bsky.social · 11/02/2026
Our new paper in @natcomms.nature.com is now online-early! We describe independent evolution of bacterial genomes of only ~50–52 kb — the smallest known outside cellular organelles — revealing striking convergence toward minimal gene sets. 🔗 doi.org/10.1038/s414...
The visualization of two bacterial genomes, of 50 and 52kb, representing independent instances of extreme genomic reduction in ancient heritable endosymbionts of planthoppers.
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Dan Sloan @sloanevolab.bsky.social · 13/01/2026
Great collaboration with the Sanchez-Puerta lab and colleagues! @lfceriotti.bsky.social @organelledchaos.bsky.social @jumpinggenomes.bsky.social @chusteckisci.bsky.social @achristensenphd.bsky.social (and others not on bsky) www.biorxiv.org/content/10.6...
biorxiv.org
Reshaping Organellar Translation and tRNA Metabolism: The Consequences of Photosynthesis Loss and Massive Horizontal Gene Transfer
The transition to holoparasitism in plants precipitates the loss of photosynthesis, fundamentally altering the selective landscape acting on organellar genomes. These changes raise questions about the...
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Pawel Burkhardt @pawelburkhardt.bsky.social · 27/10/2025
First neurons didn’t appear overnight. We trace their roots to ancient secretory cells - showing how lifestyle & behavior shaped the evolution of first synapses.🧠🌊 #Evolution #Neuroscience Our latest in @natrevneuro.nature.com Link: rdcu.be/eMX3E @jeffcolgren.bsky.social @msarscentre.bsky.social
rdcu.be
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution
Nature Reviews Neuroscience - Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were...
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Jess @jumpinggenomes.bsky.social · 21/11/2025
I love mite mt-tRNAs! I did some tRNA-seq on spider mites, and it was the first place I found this sense/antisense expression (+ some crazy short tRNAs). But I could still find all 22 tRNAs. With the mealys, it looks like this process has gone to replacement. Mirror expression -> gene loss
pmc.ncbi.nlm.nih.gov
Hopeful monsters: unintended sequencing of famously malformed mite mitochondrial tRNAs reveals widespread expression and processing of sense–antisense pairs
Although tRNA structure is one of the most conserved and recognizable shapes in molecular biology, aberrant tRNAs are frequently found in the mitochondrial genomes of metazoans. The extremely degenerate structures of several mitochondrial tRNAs ...
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Jess @jumpinggenomes.bsky.social · 15/11/2025
I certainly like to think about it! I mention the implications for early decoding systems in the discussion because theres been a history of theorizing mirrored pairs of tRNAs and aaRSs at the origin of translation.
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Dan Sloan @sloanevolab.bsky.social · 14/07/2025
Please share! Our lab is recruiting a PhD student to join us starting fall 2026. Our group is broadly interested in plant molecular evolution and comparative genomics. More info about our lab and grad programs at Colorado St. is available on our lab website. sites.google.com/site/danielb...
sites.google.com
Sloan Lab
Welcome! Our research focuses on the evolutionary process at the molecular level. In particular, we investigate how a mixture of natural selection and non-adaptive forces create and maintain the amazi...
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Jess @jumpinggenomes.bsky.social · 20/05/2025
The grad students in the lab are passing around my copy right now. Page 182 mentions one of the obscure systems we work with 🪆
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Florent Waltz @florentwaltz.bsky.social · 06/05/2025
You want to start tomography? Solve structures inside cells? Reach Nyquist 😳 ? @phaips.vd.st and I have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomogram averaging, using different software! Hope it will be useful !
3.8 angstrom resolution ribosome from 33 tomograms The TomoGuide website
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Sam Lewis, Ph.D. @samlewis.bsky.social · 18/04/2025
I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4
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Jess @jumpinggenomes.bsky.social · 14/04/2025
The nested endosymbiont system of the citrus mealybug. Outer bacteria labeled in green (lipid stain), the inner bacteria in blue (DNA). These endosymbionts are normally tightly packed into eukaryotic cells but with osmotic shock, you can “pop” them out. Pink cell is a host cell with mitos in magenta
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Jess @jumpinggenomes.bsky.social · 21/03/2025
Love the comparison across different organisms. Always beautiful work and keeping an eye on the big picture. Bravo 🍾
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Florent Waltz @florentwaltz.bsky.social · 20/03/2025
The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @science.org 🎉 You can find the full story here www.science.org/doi/10.1126/... @verenaresch.bsky.social did a wonderful job on the cover and animation, she really brought it to life 👩‍🎨
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The Plant Cell @theplantcell.bsky.social · 20/12/2024
REVIEW: Expansion of the MutS gene family in plants (Daniel B Sloan, Amanda K Broz, Shady A Kuster, Viraj Muthye, Alejandro Peñafiel-Ayala, Jennifer R Marron, Dennis V Lavrov, Luis G Brieba) doi.org/10.1093/plcell/koae277
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Dan Sloan @sloanevolab.bsky.social · 21/11/2024
Did you know that orchids have a big chunk of fungal mtDNA stuck in their own mitochondrial genomes?? In this new preprint, we found that fungal-derived tRNAs are functional in the orchid mitochondria. www.biorxiv.org/content/10.1... 1/4
The coral root orchid Corallorhiza maculata
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