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Reposted by Julia Beets

Genetics Society of America @genetics-gsa.bsky.social · 06/02/2026

Check out FlyCADD, a functional impact prediction tool ⚒️ for single-nucleotide variants in #Drosophila. Read more in #GENETICS about how to use this tool for studying functional impacts of variants. buff.ly/Hts9Mjp

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Reposted by Julia Beets

FlyBase @flybase.bsky.social · 02/02/2026

This sunny and slightly less cold February morning brings six more weeks of winter and January's #TechnicalAdvances wiki.flybase.org/wiki/FlyBase... Don't forget-if you'd like your paper with a cool new technique, reagent, or resource featured in an upcoming month, flag it when you #FTYP.

wiki.flybase.org

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Reposted by Julia Beets

Genetics Society of America @genetics-gsa.bsky.social · 14/01/2026

Dive into the latest Special Issue of #GENETICS, spotlighting cutting-edge experimental and computational methods shaping the future of genetics research. These papers showcase what’s possible when method development leads the way. Read more: buff.ly/eKVzqHq

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Julia Beets @juliabeets.bsky.social · 23/12/2025

FlyCADD scores can give insights into the impact of genetic variation at single nucleotide resolution. We describe FlyCADD and demonstrate its application to study naturally segregating SNPs, interpret GWAS-identified SNPs, rank SNPs prior to follow-up, and improve genome-editing experiments 🧬🧬

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Julia Beets @juliabeets.bsky.social · 23/12/2025

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Julia Beets @juliabeets.bsky.social · 25/09/2025

Excited to attend #EDRC2025 in Alicante, starting today! If you want to know more about the impact of genetic variation, come visit my poster P-023 Saturday afternoon and learn about FlyCADD, our impact prediction tool for SNPs! 🧬

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Reposted by Julia Beets

Molecular Biology and Evolution @molbioevol.bsky.social · 20/08/2025

@jcbnunez.bsky.social et al. present an expanded release of the community-generated resource Drosophila Evolution over Space and Time (DEST 2.0), and showcase it by studying the species' demographic history and signatures of adaptation. 🔗 doi.org/10.1093/molbev/msaf132 #evobio #molbio #drosophila

MBE - Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource

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Julia Beets @juliabeets.bsky.social · 17/08/2025

Excited to be in Barcelona for #ESEB2025 ! If you want to know more about the application of FlyCADD for SNP impact prediction in D. melanogaster, I'll be presenting this work Tuesday 19th 12.45-1PM! Or catch our group at poster P02.334 to know more about the impact of SNPs 🧬☀️

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Julia Beets @juliabeets.bsky.social · 07/03/2025

FlyCADD was developed by applying the CADD framework (Kircher et al. 2014) for the first time to an insect genome, using available genome annotations for D. melanogaster and a drosophilid whole genome alignment. All FlyCADD impact prediction scores are available on Zenodo!

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Julia Beets @juliabeets.bsky.social · 07/03/2025

FlyCADD provides impact prediction scores for any SNP on the D. melanogaster genome! We show FlyCADDs abilities in: - ranking candidate SNPs (from GWAS/E&R) for variant prioritization - interpretation of naturally occuring SNPs - refining of CRISPR-Cas9 experimental design

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Julia Beets @juliabeets.bsky.social · 07/03/2025

Preprint alert: FlyCADD! 🧬 Excited to share FlyCADD: impact prediction tool scoring the functional impact of any single nucleotide variant across the entire Drosophila melanogaster genome, to distinguish causal from neutral SNPs www.biorxiv.org/content/10.1...

biorxiv.org

Predicting the functional impact of single nucleotide variants in Drosophila melanogaster with FlyCADD

Understanding how genetic variants drive phenotypic differences is a major challenge in molecular biology. Single nucleotide polymorphisms form the vast majority of genetic variation and play critical...

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