Sign in

Pliotas Group

@pliotasgroup.bsky.social
316 followers 240 following 11 posts

Mechanosensitive channels & Membrane Proteins - Structural EPR Spectroscopy at The University of Manchester - DEER/PELDOR/PDS pliotasgroup.org

PostsRepliesMedia
Pliotas Group @pliotasgroup.bsky.social · 09/05/2026
In this study published in @natcomms.nature.com we used #PELDOR #DEER #EPR spectroscopy to monitor the entire pH-dependent conformational ensemble of the membrane SbmA peptide transporter www.nature.com/articles/s41...
nature.com
Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters - Nature Communications
SbmA is a proton-driven transporter that imports antimicrobial peptides andstructurally resembles the transmembrane domain of ABC-transporters. Here, authors show through cryo-EM structures, EPR spect...
010
Pliotas Group @pliotasgroup.bsky.social · 21/03/2026
In our study in @natcomms.nature.com we used #EPR #DEER #PELDOR spectroscopy with single subunit heterologous spin labelling and monitored the entire cap conformational ensemble of the human mechanosensitive TRAAK channel and showed it adopts two states in membranes. www.nature.com/articles/s41...
nature.com
Swapped and non-swapped TRAAK states co-exist in membranes at a ratio influenced by temperature - Nature Communications
TRAAK is expressed in the nervous system and helps regulate neuronal excitability. Here, the authors use EPR to quantify the relative populations of TRAAK’s swapped and non-swapped cap states in membr...
185
Reposted by Pliotas Group
stradi-various.bsky.social @stradi-various.bsky.social · 12/12/2025
15 PhD positions fully funded! Apply until 6 January 2026 www.findaphd.com/phds/?Keywor... #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #ResearchOpportunities#PhDPositions#MSCA#EU#Antimicrobialresistance#Microbiology#Structuralbiology
findaphd.com
stradivarious PhD Projects, Programmes & Scholarships - 26 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in stradivarious. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
003
Pliotas Group @pliotasgroup.bsky.social · 28/10/2025
We have a new academic post opening for a Lecture/Senior-Lecturer in Structural Biology @mcf-uom.bsky.social @fbmh-uom.bsky.social @manchester.ac.uk The University of Manchester is ranked among the top Universities worldwide. QS world rankings: 34th (2025) www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Lecturer / Senior Lecturer in Structural Biology:Oxford Road
The purpose of this post is to undertake high quality research and also excellent teaching. Hence, the ability to enhance teaching activities within our UG/PG programmes will also be expected.
043
Reposted by Pliotas Group
International EPR Society @epr-esr.bsky.social · 12/09/2025
Congratulations to Maria Chiara Pagliero and Anand Anilkumar who were the winners of the IEPRS Poster Prizes awarded from the International EPR Society at the 10th EFEPR Summer School at The University of Manchester @officialuom.bsky.social
032
Pliotas Group @pliotasgroup.bsky.social · 06/08/2025
www.nature.com/articles/s41...
nature.com
Modeling protein conformational ensembles by guiding AlphaFold2 with Double Electron Electron Resonance (DEER) distance distributions - Nature Communications
AlphaFold2 default prediction pipeline assigns predominantly a single conformation for a given input sequence. Here, authors developed DEERFold, which incorporates experimental Double Electron Electro...
020
Pliotas Group @pliotasgroup.bsky.social · 15/07/2025
In our study @elife.bsky.social we uncover the mechanism of mPPase inhibition. Over 20x structures to date are in a symmetric form. We use EPR(PELDOR/DEER) and reveal asymmetric binding at the active site while maintaining symmetric conformation at periplasmic site elifesciences.org/reviewed-pre...
1106
Reposted by Pliotas Group
International EPR Society @epr-esr.bsky.social · 14/05/2025
@Bruker's ELEXSYS E580Q Spectrometer has found its new home at the University of Manchester (@OfficialUoM)! Watch as an empty lab is turned into a cutting-edge #EPR lab & hear from Prof. Christos Pliotas, who leads the research group driving innovation. 👉 youtu.be/Hz4fCqh8PeY [youtu.be]
youtu.be
ELEXSYS E580Q Spectrometer Installation, BioEmPiRe Centre for Structural Biological EPR Spectroscopy
YouTube video by Bruker
152
Reposted by Pliotas Group
Magnetic Resonance News @nmr900.bsky.social · 16/04/2025
Wednesday, April 23, 9 am EDT / 3 pm CEST, IVEM webinar, Christos Pliotas @pliotasgroup.bsky.social University of Manchester, Accessing uncharted membrane protein ensembles by structural biological EPR spectroscopy www.eprseminars.org #NMRchat #NMR #EPR #ESR 🧲 🧪
webinar poster
022
Reposted by Pliotas Group
International EPR Society @epr-esr.bsky.social · 17/03/2025
2025 IES John Weil Young Investigator Award: Nino Wili his outstanding contributions to theory and instrumentation in the field of EPR spectroscopy.
093
Reposted by Pliotas Group
International EPR Society @epr-esr.bsky.social · 17/03/2025
2025 IES Medal in Biology/Medicine: awarded to Olav Schiemann for his seminal contributions advancing the field of EPR in Biology via his pioneering efforts to resolve structural aspects of spin labelled nucleic acids and proteins.
062
Reposted by Pliotas Group
Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · 04/03/2025
Early-career fellowships at the University of Manchester! To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers: www.bmh.manchester.ac.uk/research/sup...
bmh.manchester.ac.uk
Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester
Find out about and apply for a Bicentenary Early Career Research Fellowship.
047
Reposted by Pliotas Group
International EPR Society @epr-esr.bsky.social · 03/03/2025
Apply now for the 10th EFEPR Summer School in Manchester, UK, 31st Aug – 6th Sept 2025. Attendees will receive training in advanced EPR theory & methods including hands on practical sessions. chemistry.manchester.ac.uk/epr/connect/... Expression of interest deadline: 21st Mar 2025
chemistry.manchester.ac.uk
Events - EPSRC National Service for Electron Paramagnetic Resonance Spectroscopy - The University of Manchester
043
Pliotas Group @pliotasgroup.bsky.social · 10/02/2025
In our recent article we show the YbiO mechanosensitive channel can achieve pore openings of 3nS under membrane tension equalling the largest known gated-pore MscL and we also solve a cryo- EM structure of a YbiO in a sub-open state. Great effort by @lane-b.bsky.social www.cell.com/structure/fu...
cell.com
The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore
Lane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances equivalent to the largest gated-pore in nature when subjected to membrane tension. Single-channel analysis shows...
1165
Pliotas Group @pliotasgroup.bsky.social · 02/02/2025
We reviewed recent pulsed EPR Spectroscopy (PELDOR/DEER/PDS) applications on integral membrane proteins, enabled through Spin Labelling. Great to see the field moving forward! www.sciencedirect.com/science/arti...
0236
Pliotas Group @pliotasgroup.bsky.social · 24/01/2025
New starter pack on EPR - ESR spectroscopy: go.bsky.app/KJZ4P8X
0123