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Joni Coleman

@jonicoleman.bsky.social
698 followers 612 following 634 posts

Senior Lecturer in Statistical Genetics at KCL. Group GitHub: github.com/ColemanResearchGroup/Gro…. Views own. He/Him

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Joni Coleman @jonicoleman.bsky.social · 05/10/2026
Most obvious (and deserved) Nobel prize for years
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Joni Coleman @jonicoleman.bsky.social · 29/09/2026
@johanzvrskovec.bsky.social
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Joni Coleman @jonicoleman.bsky.social · 29/09/2026
I am not at #WCPG2026 (the baby whose birth kept me from WCPG 2025 has his first week at nursery), but fortunately LOADS of my peeps are there to reduce my KOMO! Check out lots of posters from the STAG group, and a talk from the excellent Liza Kyrylova on her adventures in tandem repeat calling...!
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Statistical, Translational, and Analytic Genetics Group (KCL) @coleman-group-kcl.bsky.social · 17/09/2026
Out today in @ejpt.bsky.social: doi.org/10.1080/2000... Jacob Knyspel shows that some of the genetic factors previously implicated in post-traumatic disorder vary in effect depending on the traumatic events to which people have been exposed. 1/5
doi.org
Identifying differential interactions of potentially traumatic experiences with genetic risk for posttraumatic stress disorder
Background: Posttraumatic stress disorder (PTSD) occurs following potentially traumatic experiences, but not everyone who experiences trauma develops PTSD. Genetic factors play an important role in...
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Joni Coleman @jonicoleman.bsky.social · 20/08/2026
static.klipy.com
Jimmy Fallon's Poetic Performance
Alt: A black and white GIF of Jimmy Fallon's dressed as a beatnik, clicking his fingers like he is at a poetry slam in the 1950s.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 19/08/2026
The second iteration of the Eating Disorders Genetics Initiative 2 (EDGI2) study is actively recruiting in the United States, United Kingdom, and Australia. See EDGI2-US (edgi2.org), EDGI2-AUS (edgi2.org.au), EDGI-UK (edgiuk.org).
edgi2.org
EDGI2 – Eating Disorders Genetics Initiative 2
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 19/08/2026
✨Publication alert!✨The Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) has, for the first time, identified genetic factors associated with binge eating and compared them to the genetic factors linked to anorexia nervosa. doi.org/10.1038/s442...
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NIHR Biomedical Research Centre: Maudsley @nihrmaudsleybrc.bsky.social · 19/08/2026
New research led by @kingsioppn.bsky.social + @pgcgenetics.bsky.social is the largest genetic study of anorexia nervosa to date, and the first to compare the genetics of people with binge-eating behaviours to those without an eating disorder. www.maudsleybrc.nihr.ac.uk/news/major-i...
Major international study marks step forward in genetic understanding of eating disorders  “This work is really important - we go beyond anorexia nervosa and start to understand the genetics of binge eating, which affects many people with eating disorders. We're hopeful that our findings will allow future research to improve 
the lives of people 
with all eating 
disorders.”
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Statistical, Translational, and Analytic Genetics Group (KCL) @coleman-group-kcl.bsky.social · 19/08/2026
www.maudsleybrc.nihr.ac.uk/news/major-i...
maudsleybrc.nihr.ac.uk
Major international study marks step forward in genetic understanding of eating disorders - NIHR Maudsley Biomedical Research Centre (BRC)
Related Posts
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Joni Coleman @jonicoleman.bsky.social · 19/08/2026
www.kcl.ac.uk/news/interna...
kcl.ac.uk
International study advances genetic understanding of eating disorders | King's College London
A major new study carried out in collaboration with an international partnership of researchers, has, for the first time, compared the genetics of people with binge eating versus those without any eat...
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Statistical, Translational, and Analytic Genetics Group (KCL) @coleman-group-kcl.bsky.social · 19/08/2026
Thrilled to see the first major publication from the group out today in Nature Mental Health! In this paper, we lay out the first parts of the common genetic architecture of binge eating including, with specific regions of the genome contributing to risk. www.nature.com/articles/s44...
nature.com
Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes - Nature Mental Health
This research identified six areas in the genome that are associated with binge eating, and eight areas that are associated with anorexia nervosa, in people of European ancestry. Binge eating has both...
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Joni Coleman @jonicoleman.bsky.social · 19/08/2026
Super excited to see this out! If you want to savour the full paper for later, the excellent @helenadavies.bsky.social and I wrote an accompanying Briefing to this paper, which you can find here: www.nature.com/articles/s44...
nature.com
Binge-eating behavior and anorexia nervosa have shared and distinct genetic components - Nature Mental Health
Genome-wide association studies of individuals with binge-eating behavior, anorexia nervosa or neither identify distinct genetic associations with each phenotype. Although both eating disorder phenoty...
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Frank Harrell @f2harrell.bsky.social · 26/06/2026
Very nice article and demonstration. I'd like to see the addition of "chunk tests" that don't try to separate hard-to-separate predictors. @rpsychologist.com
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GWAS Catalog @gwascatalog.bsky.social · 26/06/2026
Meet PEGASUS 🧬 A new community standard for reporting predicted effector genes. Making post-GWAS predictions more FAIR, comparable, and reusable across studies. Read the bioRxiv preprint: www.biorxiv.org/content/10.6... #GWAS #Genomics #OpenScience
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
*LAUREL (autocorrect fail)
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
purplesloth.itch.io/genetic-pinb...
purplesloth.itch.io
Genetic Pinball by PurpleSloth
Play in your browser
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Developed "genetic pinball". Pinball, but difficulty is set randomly by lottery at the start. Player can set the landscape to restructure the society of the game, with effects on gameplay. Using to leverage the game as a recruitment tool for new cohort, but also as a sci comm tool #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Still considerable public support for the concept of human races in Germany. Racism under discussed and under studied. Race theory predates and postdates Naziism. Published roadmap towards a race critical bioscience in Germany. An academic piece, but has had impact on media #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Back in Germany. Research group at Max Planck in Berlin. G-E interplay and lifecourse epigenetics in Germany, alongside social and ethical perspectives. Discussed the role of sociogenomics in German history e.g. in link.springer.com/article/10.1... #BGA2026
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Beyond a Shared History: A Biosocial Perspective on Sociogenomics and Racism in Germany - KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie
Recent advances in sociogenomics offer new opportunities to integrate genetic and epigenetic measures into social science research on human lifespan development. Now, German social science cohorts have followed suit with this global trend. We anticipate that the integration of genetic measures into German social science cohorts is likely to be met with hesitation and dismay. Historically, racialized pseudo-science disguised as genetic research was used to justify the political exploitation, oppression, and genocide conducted by colonial and Nazi Germany regimes. In response, German institutions and social sciences actively avoided race-related research. However, avoiding the intersection of socially constructed race and genetics may stall the deconstruction of enduring racial discrimination and the identification of racialized social inequalities. Recent survey studies show that half of the German population still believe in the existence of biologically distinct human “races” and that racism is rampant. This article is aimed at providing a biosocial perspective on sociogenomics and racism in Germany. First, we discuss the biologistic construction of race that became prevalent in colonial and Nazi Germany. We argue that racist legacies are sources of social inequality in contemporary German society. We further review recent human genomic science that clearly demonstrates that there is no biological basis to socially constructed race. Second, we propose a biosocial perspective that integrates how genes “get out of the skin” and racism “gets under the skin”. Transactional genetic effects, which involve human behavior and interactions between people in society, are expected to depend on environmental inequalities tied to systemic racism. We summarize recent sociogenomics studies using polygenic indices and epigenetic profile scores showing that a) genes contribute to complex human traits and b) the expression of genetic variation is affected by socioeconomic and racialized inequality. Finally, we offer a roadmap toward race-critical biosocial research that breaks with the historically informed avoidance of race to reconstruct race-critical concepts, datasets, and scientific systems.
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Next is Laura Raffington talking about sociogenomics in Germany, videogames, and racism. LR's husband is a Black German, produced a film about experience of growing up as a Black German. LR was interested in integrating genetics into studying behaviour, went to Texas to learning #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Someone needs to decide whether the juice is worth the squeeze. Often deferred ethical responsibility to others, sometimes not clearly to anyone. Interview group probably more ethically engaged, but still not taking on the ethical role #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Specific for BG Heightened responsibilities. Risk of public misinterpretation, especially given risk of harm and history of misuse. Responsibility remains within confines of general role #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
10 academic, 13 journalists. Roles and responsibilities. Editors as mediators or shepherds, working between authors and reviewers. Journalists as translators or interrogators. Making science accessible #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Interviewed journal and media editors with experience in publishing or reporting on complex trait research. Snowball approach from initial contacts in journals, targeted approach for journalists Obtained demographics, interview notes, inductive-deductive approach to qualitative research #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Now Daphne Martschenko talking about academic and journalistic publishing. Academic publishing ruled by editorial guidelines and policy. Media coverage also based on guidelines but different. Benefits and downsides, much broader reach but can also drive misinformation. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Suggestions: where possible, get explicit consent at least from the person whose data is being used [would an IRB find this enough?] Consider ethical discussion and implications in methods papers. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Why missing? Not contacted? Did not join when invited? Actively said no? Attrition? Dead? Different reasons have different implications - active no or active withdrawal shouldn't be imputed. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Not clear to person who consents that we can do this type of thing, so could void informed consent. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Is it accurate enough? Not perfect, but it's likely to be close (and will get better as methods are improved) Who owns the data? We have consent for the originating data, and we ask for family history. But don't have the same opt-out. Also combine with other data to create something new. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Under GDPR, genetic data is special category personal data. Does imputed data count? Can this be anonymised? We don't know who they are, but we know their relatives in a way that is effectively identifying. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
MI is very useful and allows us to do valuable science. But, need to think about the ethics of this. Do we need informed consent to impute people's data? Is this identifiable data? Why is the data missing in the first place? #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Now Margot van de Weijer discussing ethical and legal concerns over Mendelian imputation. MI allows for parental genotypes on the basis of offspring genotypes, in various forms and with various limitations. Useful for estimating genetic nurture effects. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Those who view PS as essential wanted BGA to provide mentorship. BGA action: promoting collaboration and recognition, providing mentorship and resources #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Needs, barriers, and solutions 50% thought PS essential to career. Graduates and postdocs saw lack of training as a barrier, all report wanting more training as a researcher Time and funding needed, lack of institutional support and incentives as a barrier #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
41 responses, 37 complete. 87% at least occasionally engaged in public science work, across a wide range of outlets. Social media primarily via LinkedIn and Facebook, with others represented. Roughly 50/50 between broad use (3+ platforms) and narrow use #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Wanted to understand barriers, needs and solutions to engaging in public science across behavioural geneticists at different career levels #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 26/06/2026
Morning. I'm in the Public Science plenary at #BGA2026 @evangiangrande.bsky.social is chairing and introducing the session. First up is Camille Williams and Robbee Wedow discussing the results of the recent public science BGA/ISPG/IBANGS survey
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
See negative interaction between MDD PRS and team sports for MDD [but need to include covariate-by-main effect terms], but not for broad exercise. Interaction effectively implies team sport partly mitigates association of high PRS with high depression risk. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Finally, Yeliz Eski talks about Associations of Physical Activity and Genetic Liability With Mental Health Problems in Adolescents. Used Trails and Lifelines cohorts to examine physical activity metrics on MDF, anxiety, and ADHD in context of PRS for each disorder #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Speculation: Predisposition for BIP but not frank disorder is associated with better educational attainment, but prodromal/onsetting disorder is disruptive and results in poorer educational outcomes #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
See positive population and within sibship association between BIP PGS and educational attainment in UK Biobank and MoBA. See positive association with school performance and BIP with early ages (10) in Norway and Netherlands, but this becomes null at later adolescence (14). #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Earlier school performance is often better among people with bipolar disorder, so is the onset of BIP the disruption rather than an underlying predisposition? VM examined genetic association of BIP PGS and education attainment, and between school performance and later BIP diagnosis #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Next is Vaishnavi Madhavan talking about Bipolar Disorder and Education: Deciphering a Complex Relationship using Genetic and Sibling Differences People with bipolar disorder tend to have poorer educational outcomes, but the genetic correlation is positive. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Yep - it's a struggle. We tend to just put them down in their nappy when the room is very warm. The lullaby trust has some good pointers as ever: www.lullabytrust.org.uk/baby-safety/...
lullabytrust.org.uk
Hot weather - The Lullaby Trust
When the weather’s hot or you’re on holiday, these tips help keep your baby safe and comfortable this summer, reducing the risk of SIDS...
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Imputation also allows boosted within-family GWAS and mitigates against ascertainment bias. Can also use this for rare variant analysis, see 26 genes with excess PTVs or damaging missense (including in internalising gene PCLO) #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
See strong rg with previous cognitive GWAS, some residual rg with non-cognitive EA (but so do other cognition GWAS, so not concerning). #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Can then do GWAS on intelligence in 450k UK Biobank individuals, boosting GW associations by 150 hits. See improvement in PGS prediction with external cohorts compared to real data. #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Fluid intelligence is retaken multiple times by some UK Biobank folks, can integrate all measures and impute missing using auxiliary variables (including, among others, cheese intake) #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Next is David van den Berg talking on using imputation of fluid intelligence scores to reduce ascertainment bias and increase power for analyses of common and rare variants. UK Biobank fluid intelligence test is only available* for an ascertained subset * Availability not guaranteed #BGA2026
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Joni Coleman @jonicoleman.bsky.social · 25/06/2026
Next is Morgan Lynch, speaking about an Epigenome-Wide Association Study of Loneliness in Older Adulthood. No GW-sig results, no replication of previous work. But a good demonstration of the need for and value of robust approaches to EWAS. Ongoing work, opportunities & discovery to come #BGA2026
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