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Joel Miesfeld

@joelmiesfeld.bsky.social
217 followers 121 following 26 posts

Assistant Professor, Ophthalmology and Visual Sciences, Medical College of Wisconsin. Visual systems development, gene regulation, RGCs, dev bio and more. Views are my own. www.mcw.edu/departments/ophthalmolo…

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Reposted by Joel Miesfeld
Phil Ruzycki @phruzycki.bsky.social · 08/09/2026
🚨 New preprint 👀! Led by Sohini Rebba in the lab, a collaboration with @clark-lab-retina.bsky.social & @macdonaldlab.bsky.social to improve the reference transcriptome for our studies of the killifish retina. 🐟
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Joel Miesfeld @joelmiesfeld.bsky.social · 04/09/2026
mcw.wd503.myworkdayjobs.com/en-US/Extern... We are looking for someone with lab experience to join the team and help out with our studies of RGC genesis, survival and regeneration. Please share!
mcw.wd503.myworkdayjobs.com
Research Technologist II Ophthalmology & Visual Sciences
Summary The applicant will join the Miesfeld laboratory at the Medical College of Wisconsin Eye Institute and perform research tasks under the guidance of Dr. Joel B. Miesfeld. The research performed ...
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Reposted by Joel Miesfeld
Levi Todd @levi-todd.bsky.social · 27/08/2026
First paper entirely from our lab is out in the wild! We tested if reprogramming still works in the aged CNS and found the aged retina blocks neurogenesis both intrinsically in Müller glia and through exacerbated inflammation. Then point at some ways to overcome this. www.pnas.org/doi/10.1073/...
pnas.org
Aging limits neuronal regeneration from glia in the mouse retina | PNAS
Reprogramming resident glia into neurons holds great therapeutic promise for neurodegenerative diseases across the central nervous system, yet thes...
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Justin Kumar @flyeyelab.bsky.social · 25/08/2026
Many thanks to all keynote speakers, session speakers, discussion leaders, and attendees for making the 2026 GRC on Visual System Development the best one ever. Can't wait to see everyone again at the 2028 meeting in Il Ciocco, Italy
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Kristen Kwan @blockintheback.bsky.social · 21/08/2026
📣 The Department of Ophthalmology and Visual Sciences @utah.edu is recruiting! We seek researchers addressing exciting questions in vision science using innovative approaches. Join our community @moraneyecenter.bsky.social! Repost and contact me with questions! utah.peopleadmin.com/postings/206...
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Joel Miesfeld @joelmiesfeld.bsky.social · 18/08/2026
I’m excited to share the newest publication from the lab where we charactize the zebrafish Atoh7 retinal lineage in wild type and Atoh7 mutants, discover an Atoh7 negative RGC population, and find lineage positive cells in the CNS outside of the optic tectum. iovs.arvojournals.org/article.aspx...
iovs.arvojournals.org
Lineage Tracing Reveals atoh7-Positive and Negative Retinal Ganglion Cell Populations in the Zebrafish Retina | IOVS | ARVO Journals
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Justin Kumar @flyeyelab.bsky.social · 07/08/2026
The 2026 GRS/GRC on Visual System Development begins tomorrow. It is going to be a great meeting. Jeremy Kay, Kristen Kwan, Robert Johnston and I are looking forward to seeing you in beautiful Maine. Safe travels to all attendees. See you in a day!
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Kristen Kwan @blockintheback.bsky.social · 03/08/2026
I am sincerely honored and excited to be named the Vice Chair for Vision Research at the @moraneyecenter.bsky.social at @utah.edu. I am thrilled to work with everyone to build upon the Moran's rich history in vision research. Stay tuned for much more to come - we will be growing!
healthcare.utah.edu
Moran Eye Center Names Kristen M. Kwan, PhD, Vice Chair for Vision Research
The John A. Moran Eye Center at the University of Utah has named Kristen M. Kwan, PhD, Vice Chair for Vision Research. In this leadership role, she will help guide the strategic direction of the Moran...
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Anna La Torre @latorrelab.bsky.social · 30/07/2026
My Department is HIRING! If you're excited about building an innovative research program and joining a collaborative community of scientists, we'd love to hear from you. Come be my colleague! #AcademicJobs #BasicScience #FacultySearch#AcademicJobs More details here: recruit.ucdavis.edu/JPF07708
recruit.ucdavis.edu
Assistant/Associate Professor- Cell Biology & Human Anatomy
University of California, Davis is hiring. Apply now!
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Juan Angueyra @juanonyme.bsky.social · 21/07/2026
Preprint for the first manuscript of the Angueyra Lab is out! We delve deep into cell-fate decisions during photoreceptor development and discover that the 𝘵𝘣𝘹2 paralogues play multiple roles to control the fate of the five photoreceptor subtypes in zebrafish.
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McPherson Eye Research Institute @mcphersoneri.bsky.social · 13/07/2026
Join us on Saturday, August 8th, for Vision at the Arboretum, a free, educational science event exploring the fascinating world of bird vision! This event is free and open to the public. RSVP appreciated but not required. Add it to your Calendars here: vision.wisc.edu/vision-at/
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Joel Miesfeld @joelmiesfeld.bsky.social · 12/06/2026
Look Mom, my image made the cover slide!
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Medical College of Wisconsin @medicalcollegeofwi.bsky.social · 04/06/2026
Andrea Carlson’s son Joe had a myriad of unexplained symptoms. Seeking answers, she connected with Elena Semina, PhD, ophthalmology researcher at MCW. Dr. Semina identified an ultra-rare genetic condition that finally explained Joe’s symptoms. Learn more: www.mcw.edu/mcwknowledge...
mcw.edu
For Families Facing Rare Diseases, Genetic Research Delivers Answers
Medical College of Wisconsin researcher probes gene variants for clues to the cause of congenital birth defects.
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Reposted by Joel Miesfeld
Medical College of Wisconsin @medicalcollegeofwi.bsky.social · 26/05/2026
Some people who suffer heart attacks fully recover, while others develop heart failure within months. At MCW, researchers linked polyploidy — or duplicated genetic material in cells — to worse post-heart attack outcomes. Learn more about their recent study: www.mcw.edu/mcwknowledge...
mcw.edu
In New Study Researchers Connect Polyploidy in Heart Muscle Genes to Worse Outcomes
Using a new genetics tool at MCW, a research team found that cells with extra copies of their genome correlated with worse heart performance.
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Anna La Torre @latorrelab.bsky.social · 13/05/2026
Excited to share our new paper! This work explores how Sonic hedgehog signaling helps coordinate retinal patterning and neurogenesis, including regulation of both cell cycle exit and progenitor competence during mammalian eye development journals.biologists.com/dev/article/...
journals.biologists.com
Roles of sonic hedgehog signaling in retinal patterning and neurogenesis during mammalian eye development
Summary: Temporal disruption of sonic hedgehog signaling reveals stage-specific roles in eye cup patterning and in regulating proliferation, progenitor competence and fate specification during retinal...
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Anna La Torre @latorrelab.bsky.social · 08/05/2026
#ARVO2026 was fantastic! I’m really honored to have been elected to the AMPC and STOKED to serve alongside one of my favorite scientist (and human), @blockintheback.bsky.social
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BWJones @bwjones.bsky.social · 03/05/2026
It’s @aoiplab.bsky.social, @icanhasmiranda.bsky.social and company at #ARVO2026
A group of vision scientists smiling into the camera.
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Joel Miesfeld @joelmiesfeld.bsky.social · 02/05/2026
Off to #ARVO2026 with @icanhasmiranda.bsky.social and Ross!
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Sarah Ross @sarahross1.bsky.social · 28/04/2026
Just 2 weeks left to apply: Tenure-track faculty position at the University of Pittsburgh for someone studying the mechanisms of pain. Looking for interactive colleagues. Please spread the word! Info here: cfopitt.taleo.net/careersectio...
cfopitt.taleo.net
Job SearchOracle Taleo
Mobile
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The New York Times @nytimes.com · 24/04/2026
“Our baby was born deaf, and now he can hear.” A new gene therapy is helping children with a rare form of hearing loss.
nyti.ms
New Gene Therapy Enables Children With a Rare Form of Deafness to Hear
The treatment, the first of its kind, was approved by the Food and Drug Administration on Thursday. “Our baby was born deaf, and now he can hear,” said one parent.
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Anna La Torre @latorrelab.bsky.social · 21/04/2026
Our new paper is out! 🎉 Let-7 doesn’t act through a single pathway: it controls neocortical neuron fate and migration via distinct downstream mechanisms, with RBX2 dedicated to migration. A new layer of post-transcriptional control shaping cortical development www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Phil Ruzycki @phruzycki.bsky.social · 09/04/2026
New paper out 🚨! Excited to share this collab between my lab and @kerschensteiner.bsky.social's group, expertly led by Ning Shen. We used a genome-wide in vivo CRISPR screen to uncover novel neuroprotective strategies in the P23H mouse retina, with validation in a new human retina culture model.
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Daniel Kerschensteiner @kerschensteiner.bsky.social · 09/04/2026
New study led by Ning Shen w/ @phruzycki.bsky.social: a genome-wide in vivo CRISPR screen in a retinitis pigmentosa mouse model identifies genes whose loss accelerates photoreceptor death. Overexpressing two, UFD1 and UXT, preserves photoreceptors, retinal function, and vision. 🧵
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Zebrafish Rock! @zebrafishrock.bsky.social · 23/03/2026
“The atoh7:iCre;ubi:Switch transgene combination successfully recapitulated the onset of endogenous atoh7 expression… We determined 79% of total RGCs in the wild type retina come from atoh7+ progenitor cells, a greater number than reported in the mouse retina” New from @joelmiesfeld.bsky.social 🐟
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European Zebrafish Society (EZS) @ezsociety.bsky.social · 16/02/2026
🌟 Meet the Scientific Committee: @blockintheback.bsky.social🌟 Kristen Kwan is a member of the Scientific Committee of #EZM2026, and we are thrilled to have her join us in Vienna! Stay tuned as we continue to introduce the outstanding scientists of EZM2026! 🐟🧬
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Medical College of Wisconsin @medicalcollegeofwi.bsky.social · 19/12/2025
In 2025, we captured stories that celebrated those that drive discovery, education, and community collaboration forward at MCW. As we reflect on the past year, we’re highlighting the top 10 most-viewed MCW feature stories of 2025. Learn more:
mcw.edu
The Medical College of Wisconsin’s Top Featured Stories of 2025
A look back at the discoveries, people, and moments that captured interest and advanced MCW’s mission this year.
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@arvoinfo.bsky.social‬ @arvoinfo.bsky.social · 05/12/2025
The ARVO site is experiencing very high volume, affecting ability to renew membership and submit Annual Meeting abstracts. We are extending the abstract deadline to Dec. 8, 5pm US EST. Our site is operational, so please continue to submit today and over the next three days. bit.ly/4mJ2aRV
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Wisconsin State Journal @madison.com · 28/11/2025
Ken Poss, who first discovered the fish could regenerate their heart tissue, moved his lab from Duke University to the Morgridge Institute at UW-Madison a year ago.
madison.com
Zebrafish may teach us how to regrow our hearts, researcher at UW-Madison says
Ken Poss, who first discovered the fish could regenerate their heart tissue, moved his lab from Duke University to the Morgridge Institute at UW-Madison a year ago.
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Medical College of Wisconsin @medicalcollegeofwi.bsky.social · 21/11/2025
The chemotherapy drug doxorubicin helps patients by killing cancer cells, but it has also been shown to damage heart cells. MCW’s Dr. Chun Liu has set out to find how to protect them from this toxicity. Learn more: www.mcw.edu/mcwknowledge... #CardiovascularResearch #Research
mcw.edu
To Protect the Heart from Chemotherapy, Researcher Looks to Genes
The Chun Liu Lab examines why some heart cells survive the cardiotoxicity caused by chemo – and how that insight can help prevent heart disease.
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Joel Miesfeld @joelmiesfeld.bsky.social · 13/11/2025
Interested in getting a PhD in biomedical sciences? Apply for the Interdisciplinary Doctoral Program in Biomedical Sciences at the Medical College of Wisconsin! For full consideration please submit your application by December 5, 2025; www.mcw.edu/education/gr...
mcw.edu
Interdisciplinary Doctoral Program in Biomedical Sciences (IDP) | Graduate School Programs | Medical College of Wisconsin
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Joel Miesfeld @joelmiesfeld.bsky.social · 29/10/2025
Are you or do you know a current undergraduate student who wants to pursue research? Our Summer Program for Undergraduate Research (SPUR) application is now open! (reposting from the MCW Grad school X account) Apply here: admissions.mcw.edu/register/sum...
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Development, Regeneration and Neurophysiology @drn-sheffield.bsky.social · 29/10/2025
Today’s speaker in our DRN external seminar series is Dr Ryan MacDonald @macdonaldlab.bsky.social (University College London) Sponsored by the Physiological Society @physoc.bsky.social Host: Emily Noël @noelresearchlab.bsky.social All welcome!
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Michel Cayouette @michelcayouette.bsky.social · 22/10/2025
You are a postdoc looking for an opportunity to present your latest work and discuss with leaders in the field? Apply to the early career scientists seminar series @ircm.bsky.social ! If selected, we pay for your expenses to come spend a day with us and give a seminar! www.ircm.qc.ca/en/news-deta...
ircm.qc.ca
Call for applications: A fifth edition for the Early-Career Scientist Seminar Series
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Medical College of Wisconsin @medicalcollegeofwi.bsky.social · 21/10/2025
For people with hemophilia A, a simple cut or bump can cause excessive bleeding or bruising. MCW’s Dr. David A. Wilcox is working with colleagues to develop a new #GeneTherapy that could transform how patients with the disease are treated. #Research Learn more: www.mcw.edu/mcwknowledge...
mcw.edu
New Gene Therapy for Severe Hemophilia A Developed and Tested at MCW Achieves Promising Results
A decades-long effort and a fruitful collaboration could lead to a better quality of life for patients with this genetic blood disease.
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Anna La Torre @latorrelab.bsky.social · 10/10/2025
New preprints from the lab (3)! www.biorxiv.org/content/10.1...
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Anna La Torre @latorrelab.bsky.social · 17/09/2025
New preprints from the lab!! (2)
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Anna La Torre @latorrelab.bsky.social · 17/09/2025
🎉 New preprints from the lab! (1) www.biorxiv.org/content/10.1...
biorxiv.org
Novel Roles of Sonic Hedgehog Signaling in Retinal Patterning and Neurogenesis During Mammalian Eye Development
The Sonic Hedgehog (Shh) signaling pathway is essential for the patterning, growth, and morphogenesis of many tissues. During early eye development, Shh is critical for the formation of the two optic ...
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Medical College of Wisconsin @medicalcollegeofwi.bsky.social · 17/09/2025
Damaged retinal ganglion cells can lead to blindness. MCW’s Dr. Joel Miesfeld is conducting #research into the development of these cells to better identify ways to help them regenerate after damage. Learn more: www.mcw.edu/mcwknowledge... #Ophthalmology #VisionHealth #MCWKnowledge
mcw.edu
Preventing Blindness by Untangling the Genetic Network of Vision Neurons
Dr. Joel Miesfeld’s lab studies the mechanisms behind retinal ganglion cells to better understand vision development.
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Joel Miesfeld @joelmiesfeld.bsky.social · 16/09/2025
A big thanks to the NEI for supporting my new R01 and MCW for highlighting the research focus. We’ve already made some interesting discoveries and I’m excited to see how the research progresses for years to come. www.mcw.edu/mcwknowledge...
mcw.edu
Preventing Blindness by Untangling the Genetic Network of Vision Neurons
Dr. Joel Miesfeld’s lab studies the mechanisms behind retinal ganglion cells to better understand vision development.
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MCW Graduate Student Association @mcw-gsa.bsky.social · 12/08/2025
Check out this 40x confocal image of a transgenic zebrafish eye showing UV (red) and blue cones (green), key for color vision. Zebrafish use UV vision for prey detection and navigation! Got interesting data or images? Send your science with a brief description to be featured!
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Brian Clark @clark-lab-retina.bsky.social · 06/08/2025
Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…
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MCW Graduate Student Association @mcw-gsa.bsky.social · 05/08/2025
🎉 MCW grad students: come to the GSA Welcome Social on Aug 22, 5–8 PM at Hoyt Park! 🥪 Free Jimmy John’s, 🎲 games, ☀️ good vibes 📝 RSVP by Aug 20 by scanning the QR code!
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Joel Miesfeld @joelmiesfeld.bsky.social · 24/07/2025
Should have included these two co-organizers in the original post @icanhasmiranda.bsky.social @aoiplab.bsky.social
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Joel Miesfeld @joelmiesfeld.bsky.social · 24/07/2025
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Megan Dennis @mydennis.bsky.social · 10/07/2025
Beautiful morning in Madison at #izfc2025! Grad student @nicholashaghani.bsky.social will talk today on models of ASD-DM candidate genes in the disease models session #genomejoggers
Morning view during jog in Madison
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Kristen Kwan @blockintheback.bsky.social · 07/07/2025
🚨🚨🚨 Tol2kit announcement! We have rebuilt the wiki that was corrupted a few months ago! We’re in the process of also linking it to the original address. Please visit us here: tol2kitkwan.genetics.utah.edu Thank you for your patience!! #zebrafish #transgenesis #plasmids #sharing
tol2kitkwan.genetics.utah.edu
tol2kit for kwan lab
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Wisconsin State Journal @madison.com · 17/06/2025
Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.
madison.com
Tom Still: Cancer tests continue to propel Exact Sciences, even in time of research cuts
Madison-based Exact Sciences' story illustrates that basic research — combined with hard work, strong teams and enough money — can pay off in many ways.
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MCW Graduate Student Association @mcw-gsa.bsky.social · 16/06/2025
Meet your 2025–26 GSA Officers & Reps! 👋 We’re here to keep you in the loop, host fun events 🎉, and represent your voice. Stay tuned for news, meeting reminders📅, monthly pet pics 🐾, science highlights 🔬 & more! Got ideas? DM or email us anytime! 😊
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Jeff Farrell @jeffreyafarrell.bsky.social · 13/06/2025
If you love Daniocell, but wish it could generate analyses specific to YOUR genes & cell types of interest, check out DaniocellDesktop - a new point-and-click app for Mac and Windows that enables reanalysis of the Daniocell data without programming: daniocell.nichd.nih.gov/desktop/ (1/4)
DaniocellDesktop logo, depicting a fish on a laptop screen.
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Zebrafish Rock! @zebrafishrock.bsky.social · 02/06/2025
“Our results suggest that some axons regenerate along tracts of degenerating myelin debris. However, the topography of re-innervation is different after regeneration, suggesting that new axon tracts are created to restore functional vision.” New work from @pennylamphd.bsky.social et al. 🐠
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