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Reposted by Josefa Macuada

Juan C. Landoni @jclandoni.bsky.social · 03/04/2026

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

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Josefa Macuada @jmacuada.bsky.social · 22/02/2025

I hope you find it useful! It was a pleasure exploring the data and ideas that our colleagues have contributed to this field over the past few years. We thought it was the right time to compile some mechanisms that could mediate nucleoid movement and share our perspective with the community 😊

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Josefa Macuada @jmacuada.bsky.social · 21/02/2025

Forgot to tag the protagonists of the story #mitochondria #mtDNA #nucleoids (I am new to this platform 😅). Also, we started on this topic by looking at nucleoids in disease conditions! So if you are interested, you can check it out at www.nature.com/articles/s41...

nature.com

OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution - Cell Death & Disease

Cell Death & Disease - OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution

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Josefa Macuada @jmacuada.bsky.social · 21/02/2025

Are you curious about how motile our mitochondrial genomes are 🧬? Live-cell nucleoid data inspired us to discuss exciting ideas from the field with amazing @isimolinar.bsky.social and Verónica Eisner in our new opinion at TCB 🤩! Here is a free-access link authors.elsevier.com/c/1keJq3QxxS....

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Josefa Macuada @jmacuada.bsky.social · 30/12/2024

I still haven't gotten over the shock of seeing the beautiful pearled landscape of the Mic10 KD cells! Thrilled and proud to have contributed to this story, and thank you @jclandoni.bsky.social and @sulianamanley.bsky.social for all your encouragement and @lycasworks.bsky.social for the STED fun 🔬🇨🇭

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Reposted by Josefa Macuada

Suliana Manley @sulianamanley.bsky.social · 23/12/2024

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

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Reposted by Josefa Macuada

Juan C. Landoni @jclandoni.bsky.social · 23/12/2024

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

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